High-pressure Homogenizer Design

Rayner, Marilyn

doi:10.1201/b18436-15

Cited by 1 publication

(1 citation statement)

References 96 publications

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“…Manufacturing approaches that use premix routines and recycling of emulsions can also be used to improve operational efficiency and improve emulsion quality [9]. It is worth noting here that cross-flow membrane emulsification (XME) systems of the type used in this work can be easily parallelized to increase production volumes, and it is entirely feasible to match the output of an industrial homogenizer with a similar-sized unit [10]. Membrane or channel fouling is another potential issue for these drop-by-drop approaches that needs to be carefully managed if they are to be successfully scaled up for manufacturing applications.…”

Section: Introductionmentioning

confidence: 99%

Manufacture of poly(methyl methacrylate) microspheres using membrane emulsification

Bux

Manga

Hunter

et al. 2016

Phil. Trans. R. Soc. A.

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Accurate control of particle size at relatively narrow polydispersity remains a key challenge in the production of synthetic polymer particles at scale. A cross-flow membrane emulsification (XME) technique was used here in the preparation of poly(methyl methacrylate) microspheres at a 1-10 l h(-1) scale, to demonstrate its application for such a manufacturing challenge. XME technology has previously been shown to provide good control over emulsion droplet sizes with careful choice of the operating conditions. We demonstrate here that, for an appropriate formulation, equivalent control can be gained for a precursor emulsion in a batch suspension polymerization process. We report here the influence of key parameters on the emulsification process; we also demonstrate the close correlation in size between the precursor emulsion and the final polymer particles. Two types of polymer particle were produced in this work: a solid microsphere and an oil-filled matrix microcapsule.This article is part of the themed issue 'Soft interfacial materials: from fundamentals to formulation'.

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Section: Introductionmentioning

confidence: 99%