A 32-year-old man presents to the clinic with multiple subcutaneous masses. Further history and a review of the literature are discussed. This is a case study of a patient with familial multiple lipomatosis and our management. Liposuction was performed after informed consent was obtained to manage familial multiple lipomatosis in an aesthetically pleasing manner without recurrence. Liposuction is an excellent technique for an aesthetically pleasing outcome to manage familial multiple lipomatosis. Additional therapy modalities including laser, chemicals, high-pressure tumescent injection, and Vibration Amplification of Sound Energy at Resonance (VASER) are reviewed. To avoid multiple incisions and scars, liposuction for familial multiple lipomatosis is an aesthetically pleasing, definitive treatment modality with no recurrence of lipomas.