High-pressure liquid chromatographic determination of lidocaine and its active deethylated metabolites

Hill, J. P.; Roussin, André; LeLorier, Jacques; Caillé, Gilles

doi:10.1002/jps.2600691127

Cited by 20 publications

(2 citation statements)

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“…The first syringe contained 2 mL saline to flush the IV catheter and then remove and discard 2 mL of blood. Next, 10 mL blood was collected in a second syringe for assay of lidocaine by high-performance liquid chromatography by NMS Labs, Willow Grove, PA. 38 The catheter was then flushed with 1 mL heparin 10 USP units per milliliter.…”

Section: Methodsmentioning

confidence: 99%

Estimated Maximal Safe Dosages of Tumescent Lidocaine

Klein¹,

Jeske

2016

Anesthesia &Amp; Analgesia

129

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Section: Methodsmentioning

confidence: 99%

Estimated Maximal Safe Dosages of Tumescent Lidocaine

Klein¹,

Jeske

2016

Anesthesia &Amp; Analgesia

129

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“…Plasma lidocaine levels were determined by a specific high-performance liquid chromatographic method derived from the one described by Hill et al (11). A model 450 High-Performance Liquid Chromatograph (Waters Associates, Milford, Mass.)…”

Section: Lidocaine Dispositionmentioning

confidence: 99%

Determinants of Drug Disposition in Patients with Cirrhosis†

1983

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The effects of alterations of the hepatic blood flow, the intrinsic clearance, and the anatomy of the portal circulation on drug disposition were investigated in 53 cirrhotic patients with portal hypertension using indocyanine green (ICG) and lidocaine as model drugs. ICG disposition was studied by sampling from an artery and one hepatic vein following i.v. injection, with determination of systemic and intrinsic clearances and hepatic blood flow. Lidocaine disposition was studied following i.v. and oral administration from peripheral vein disappearance curves, with determination of systemic and intrinsic clearances and systemic availability. The shunted fraction of intestinal blood flow ( f ) was measured from the combined ICG and lidocaine disposition studies. In the 53 patients, systemic clearances of ICG and lidocaine varied widely and were significantly correlated with each other (r = 0.725, p < 0.001). The systemic clearances of both ICG and lidocaine were not related to hepatic blood flow but were significantly correlated to their respective intrinsic clearances (for ICG: r = 0.948, p < 0.001; for lidocaine: r = 0.873, p < 0.001). Lidocaine systemic availability was also found to vary widely from 0.2 to 1.0. In 28 patients, f was ~0 . 1 indicating minimal extrahepatic shunting and in these patients, lidocaine systemic availability was related to its intrinsic clearance (r = -0.717, p c 0.001); in the 25 other patients with significant extrahepatic shunting (f > O.l), the extent of lidocaine systemic availability was related to both intrinsic clearance (r = -0.819, p < 0.001) and extrahepatic shunting (r = 0.913, p < 0.001). It is concluded that, in patients with cirrhosis: (i) the disposition of drugs with intermediate-high hepatic extraction ratios is no longer influenced by hepatic blood flow but becomes limited by intrinsic clearance; and (ii) the decrease of intrinsic clearance plus extrahepatic shunting, when present, are responsible for the increased systemic availability of this type of drug.In recent years, the quantification of the hepatic elimination of drugs has become more physiologically oriented. It is now recognized that, besides the activity of the hepatic drug metabolizing enzymes (intrinsic clearance), hepatic blood flow is also an important determinant of drug clearance (1). These considerations have led to a classification of drug elimination based on their hepatic extraction ratio (2). For drugs with a low hepatic extraction ratio, clearance is determined mainly by the liver's ability to metabolize the drug, i.e., intrinsic clearance, being independent of changes in liver blood flow. ~

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