High-pressure liquid chromatographic methods for ciprofloxacin hydrochloride and related compounds in raw materials

Generic ciprofloxacin tablets contain the stated amount of drug and different impurity profiles: A 19F, 1H and DOSY NMR analysis

“…The values for total impurities are close to those reported by Lacroix et al [4] and Altria and Chanter [5]. Impurities A, B, and D are by-products from the synthesis route and impurity C is a potential photolysis product [4]. Their levels are also in agreement with those reported by others authors (Table 8).…”

“…There is a strong interest in determining fluoroquinolone purity for the purpose of pharmaceutical quality control. The published analytical methods for the analysis of ciprofloxacin and its impurities in pharmaceutical formulations are based on HPLC, which is also recommended by European and US Pharmacopoeias [1][2][3][4], capillary electrophoresis [5,6] and HP TLC [7].…”

A First-Derivative Spectrophotometric Method for the Determination of Ciprofloxacin Hydrochloride in Ophthalmic Solution

“…There are several analytical methods described in the literature for the determination of ciprofloxacin hydrochlori de based on high performance liquid chromatography (HPLC) techniques [3][4][5][6][7]. HPLC is described as the official method for analysis of ciprofloxacin in the United States Pharmacopoeia, in the British Pharmacopoeia and in the Brazilian Pharmacopoeia [8][9][10].…”

Quantitative determination of ciprofloxacin and norfloxacin in pharmaceutical preparations by high performance liquid chromatography

“…HPLC is widely employed for the determination of CIP and NOR either in biological fluids, edible animal products, feed and pharmaceutical formulations (Barbosa, Berges, Sanz-Nebot, 1996;Belal, Al-Majed, Al-Obaid, 1999;Budvari-Barany et al 1991;Córdoba-Borrego, Cordoba-Diaz, Cordoba-Diaz, 1999;Husain et al 1995;Kirkland, Mccombs, Kirkland, 1994;Lacroix, Curran, Sears, 1996;Morley, Erold, 1993;Samanidou, Christodoulou, Papadoyannis, 2005;Sowinski, Kays, 2004;Thoppil, Amin, 2000;Tiefenbacher et al 1994;Torniainen, Tammilehto, Ulvi, 1996;Vybiralova et al 2005).…”