High pressure mass spectrometry of volatile organic compounds with ambient air buffer gas

Blakeman, Kenion H.; Cavanaugh, Craig A.; Gilliland, William M.; Ramsey, J. Michael

doi:10.1002/rcm.7766

Cited by 23 publications

(13 citation statements)

References 38 publications

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“…Two truly handheld instruments have been developed for analysis of CWAs, both without the use of a membrane inlet. The MX908 uses a miniaturized ion trap that operates at relative high pressures of~1 torr (Blakeman et al, 2017), yielding significant SWaP advantages. It is able to directly sample air through a restricted inlet.…”

Section: "Sniffers" For Relevant Volatile Organic Compounds (Vocs)mentioning

confidence: 99%

Fieldable Mass Spectrometry for Forensic Science, Homeland Security, and Defense Applications

Evans-Nguyen

Stelmack

Clowser

et al. 2020

Mass Spectrometry Reviews

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Mass spectrometry is commonly used in forensic chemistry laboratories for sensitive, definitive analysis. There have been significant efforts to bring mass spectrometry analysis on-site through the development of ruggedized, fieldable instruments. Testing samples in the field is of particular interest in forensic science, homeland security, and defense applications. In forensic chemistry, testing seized drugs in the field can significantly improve efficiencies in processing of related criminal cases. The screening of passengers and luggage at transportation hubs is a critical need for homeland security for which mass spectrometry is well suited to provide definitive answers with low false positive rates. Mass spectrometry can yield reliable data for military personnel testing sites for potential chemical weapons release. To meet the needs of the forensic and security communities fieldable mass spectrometers based on membrane inlet systems and hybrid gas chromatography systems have been developed and commercialized. More recently developed ambient ionization mass spectrometry methods can eliminate the time, equipment, and expertise associated with sample preparation, and so are especially appealing for on-site analysis. We describe the development of fieldable mass spectrometry systems, with emphasis on commercially available systems that have been deployed for on-site analysis of seized drugs, chemical warfare agents, explosives, and other analytes of interest to the forensic and security communities.

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Section: "Sniffers" For Relevant Volatile Organic Compounds (Vocs)mentioning

confidence: 99%

Fieldable Mass Spectrometry for Forensic Science, Homeland Security, and Defense Applications

Evans-Nguyen

Stelmack

Clowser

et al. 2020

Mass Spectrometry Reviews

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“…Daellenback et al (2016) and Bozetti et al (2017) have demonstrated the offline use of an AMS by nebulizing water-soluble filter extracts, finding adequate detection limits and good reproducibility. There are also rapid advances in miniature mass spectrometers (Blakeman et al, 2017;Snyder et al, 2016) that may eventually replace the more standard, general-purpose laboratory units. Such a Mini-MS has been demonstrated in a field unit for thermal desorption OC measurements (Cropper, 2016).…”

Section: Summary Conclusion and Future Workmentioning

confidence: 99%

Feasibility of coupling a thermal/optical carbon analyzer to a quadrupole mass spectrometer for enhanced PM_2.5 speciation

Riggio

Chow

Cropper

et al. 2018

Journal of the Air & Waste Management Association

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“…Performing mass spectrometry (MS) in a low-vacuum environment substantially reduces the cost, size, weight, and power of instrumentation and expands its applicability, making it more suitable for field applications [1,2]. is strategy is important for handheld mass spectrometers.…”

Section: Introductionmentioning

confidence: 99%

Low-Vacuum Quadrupole Mass Filter Using a Drift Gas

Jiang

Zhao

2020

International Journal of Analytical Chemistry

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Performing mass spectrometry in a low-vacuum environment can markedly reduce the cost, size, and power consumption of instrumentation by reducing the workload of the pumping system. Under a low-vacuum environment, ions in a quadrupole mass filter do not have sufficient kinetic energy in the axial direction to reach the detector for mass analysis. To resolve this problem and develop a mass spectrometer suitable for a low-vacuum environment, a mass analysis method is proposed where a drift gas is used to supply energy to the ions. A simulation model was constructed in COMSOL Multiphysics, and a simple experimental device was built to validate the proposed method. The simulation results showed that this method effectively solves these problems, and the obtained spectral peak was superior to that without drift gas flow regarding spectral peak intensity and width. The experimental results showed that the proposed method separated ions with different mass-to-charge ratios at a pressure of 20 Pa. This work provides a theoretical foundation for the development of low-vacuum mass spectrometry, which will promote portability, provide a lower threshold of use, and expand the fields of application for mass spectrometers.

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High pressure mass spectrometry of volatile organic compounds with ambient air buffer gas

Cited by 23 publications

References 38 publications

Fieldable Mass Spectrometry for Forensic Science, Homeland Security, and Defense Applications

Fieldable Mass Spectrometry for Forensic Science, Homeland Security, and Defense Applications

Feasibility of coupling a thermal/optical carbon analyzer to a quadrupole mass spectrometer for enhanced PM_2.5 speciation

Low-Vacuum Quadrupole Mass Filter Using a Drift Gas

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High pressure mass spectrometry of volatile organic compounds with ambient air buffer gas

Cited by 23 publications

References 38 publications

Fieldable Mass Spectrometry for Forensic Science, Homeland Security, and Defense Applications

Fieldable Mass Spectrometry for Forensic Science, Homeland Security, and Defense Applications

Feasibility of coupling a thermal/optical carbon analyzer to a quadrupole mass spectrometer for enhanced PM2.5 speciation

Low-Vacuum Quadrupole Mass Filter Using a Drift Gas

Contact Info

Product

Resources

About

Feasibility of coupling a thermal/optical carbon analyzer to a quadrupole mass spectrometer for enhanced PM_2.5 speciation