High prevalence of advanced NAFLD in patients with DMT2

Neuroprotective effects of Zingerone against carbon tetrachloride (CCl4) induced brain mitochondrial toxicity in Swiss albino mice

“…The deterioration of mitochondria or dysfunction of mitochondrial energy metabolism in the brain cells is a primary cause of all neurodegenerative disorders due to generation of reactive oxygen species (ROS) (Cassarino and Bennette, 1999). Carbon tetrachloride (CCl 4 ) is known clear, colorless and nonflammable liquid repeatedly used in scientific research for induce of free radical in different tissues of animals (Alam, 2017;Khan et al, 2011;Ritesh et al, 2015). CCl 4 produced trichloromethyl free radical after the biotransformation through chain reaction process (Adewole, 2012,).…”

“…Several reports are available of Zingerone in management of oxidative stress in different tissues (Aeschbach, et al 1994). Recently Alam et al (2017) has reported the Therapeutic action mechanism of Zingerone against CCl 4 induced liver mitochondrial toxicity in Swiss albino mice. Zingerone has also been reported to inhibit the lipid peroxidation and enhances the antioxidant enzyme in brain tissue (Mohammed, 2015).…”