High prevalence of alpha 1 antitrypsin phenotypes in viral hepatitis B infected patients in Iran

Hashemi, Mohammad; Alavian, Seyed Moayed; Ghavami, Saeid; Serres, Frederick J. de; Salehi, Masoud; Doroudi, Taher; Fard, Amir Hossain Mahagheghi; Mehrabifar, Hamid; Milani, Behzad; Shahri, Seyed Javad Saeidi

doi:10.1016/j.hepres.2005.09.035

Cited by 25 publications

(19 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Some studies provide evidence of an association between the heterozygous Z allele alpha-1-antitrypsin phenotype and end stage liver disease of different aetiology (19–22), but other studies (including ours) failed to identify an association between heterozygous MZ alpha-1antitrypsin deficiency and cirrhosis (23–27). We were not able to show differences in Pi MZ frequency between patients and healthy controls.…”

Section: Discussionmentioning

confidence: 61%

“…Vogel et al (29) documented that hepatitis C virus (HCV) infection is an exogenous risk factor which is required for the development of chronic liver disease in Z allele carriers (homozygotes and heterozygotes), but hepatitis B virus (HBV), alcohol abuse, and autoimmunity were not risk factors. A recent study (19) showed that AATD might be a risk factor for infected HBV individuals progressing from the carrier stage to chronic and cirrhotic stages. Bowlus et al (30) reported that male gender and obesity, but not alcohol or viral hepatitis, predispose to advanced liver disease in adults with AATD.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Alpha-1-antitrypsin phenotypes in adult liver disease patients

Topić¹,

Alempijević²,

Milutinović³

et al. 2009

Upsala Journal of Medical Sciences

View full text Add to dashboard Cite

Alpha-1-antitrypsin (AAT) is an important serine protease inhibitor in humans. Hereditary alpha-1-antitrypsin deficiency (AATD) affects lungs and liver. Liver disease caused by AATD in paediatric patients has been previously well documented. However, the association of liver disease with alpha-1-antitrypsin gene polymorphisms in adults is less clear. Therefore, we aimed to study AAT polymorphisms in adults with liver disease. We performed a case-control study. AAT polymorphisms were investigated by isoelectric focusing in 61 patients with liver cirrhosis and 9 patients with hepatocellular carcinoma. The control group consisted of 218 healthy blood donors. A significant deviation of observed and expected frequency of AAT phenotypes from Hardy-Weinberg equilibrium (chi-square = 34.77, df 11, P = 0.000) in the patient group was caused by a higher than expected frequency of Pi ZZ homozygotes (f = 0.0143 and f = 0.0005, respectively, P = 0.000). In addition, Pi M homozygotes were more frequent in patients than in controls (63% and 46%, respectively, P = 0.025). Our study results show that Pi ZZ homozygosity in adults could be associated with severe liver disease. Presence of Pi M homozygosity could be associated with liver disease via some mechanism different from Z allele-induced liver damage through accumulation of AAT polymers.

show abstract

Section: Discussionmentioning

confidence: 61%

Section: Discussionmentioning

confidence: 99%

Alpha-1-antitrypsin phenotypes in adult liver disease patients

Topić¹,

Alempijević²,

Milutinović³

et al. 2009

Upsala Journal of Medical Sciences

View full text Add to dashboard Cite

show abstract

“…Serum levels and activity of AAT have been shown to be increased as a part of acute phase response towards tissue injury and/or inflammatory conditions such as bacterial and viral infections, rheumatoid arthritis, hepatitis, carcinomas, vasculitis, and uveitis [19,20]. VKC is a chronic ocular condition represented by profound inflammation of the ocular surface and elevated eosinophils and leukocyte activation markers [5].…”

Section: Discussionmentioning

confidence: 99%

Alpha-1 Antitrypsin, a Diagnostic and Prognostic Marker of Vernal Keratoconjunctivitis

Ahsan

Salman

Alam

et al. 2014

JCDR

View full text Add to dashboard Cite

“…Patients with cirrhosis or portal hypertension from A1AT deficiency are managed the same as those with liver disease from any other cause: using cancer surveillance, tests for and management of esophageal varices, and disease-modification strategies (limiting alcohol consumption, avoiding exposure to hepatotoxic agents, and controlling obesity or weight management, etc). Vaccination against hepatitis A and B viruses is recommended for all A1AT-deficient patients, who might have an increased risk for chronic liver disease if they become infected (34). …”

Section: Managementmentioning

confidence: 99%

Diagnosis and Management of Patients With α1-Antitrypsin (A1AT) Deficiency

Nelson

Teckman

Bisceglie

et al. 2012

Clinical Gastroenterology and Hepatology

View full text Add to dashboard Cite

α1-antitrypsin (A1AT) deficiency is an autosomal co-dominant disease that can cause chronic liver disease, cirrhosis, and hepatocellular carcinoma (HCC) in children and adults and increases risk for emphysema in adults. The development of symptomatic disease varies—some patients have life-threatening symptoms in childhood whereas others remain asymptomatic and healthy into old age. As a result of this variability, patients present across multiple disciplines, including pediatrics, adult medicine, hepatology, genetics, and pulmonology. This can give physicians the mistaken impression that the condition is less common than it actually is, and can lead to fragmented care that omits critical interventions commonly performed other specialists. We sought to present a rational approach for hepatologists to manage adult patients with A1AT deficiency.

show abstract

High prevalence of alpha 1 antitrypsin phenotypes in viral hepatitis B infected patients in Iran

Cited by 25 publications

References 31 publications

Alpha-1-antitrypsin phenotypes in adult liver disease patients

Alpha-1-antitrypsin phenotypes in adult liver disease patients

Alpha-1 Antitrypsin, a Diagnostic and Prognostic Marker of Vernal Keratoconjunctivitis

Diagnosis and Management of Patients With α1-Antitrypsin (A1AT) Deficiency

Contact Info

Product

Resources

About