High prevalence of anti-Strongyloides antibody in SARS-CoV-2-infected human sera in a Thai hospital: Rapid serological screening

Sadaow, Lakkhana; Boonroumkaew, Patcharaporn; Rodpai, Rutchanee; Sanpool, Oranuch; Prasongdee, Prinya; Intapan, Pewpan M.; Maleewong, Wanchai

doi:10.1016/j.jiph.2024.05.054

Journal of Infection and Public Health

2024

DOI: 10.1016/j.jiph.2024.05.054

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High prevalence of anti-Strongyloides antibody in SARS-CoV-2-infected human sera in a Thai hospital: Rapid serological screening

Lakkhana Sadaow,

Patcharaporn Boonroumkaew,

Rutchanee Rodpai

et al.

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Cited by 2 publications

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Strongyloides Hyperinfection Syndrome Following Immunosuppressant Therapy for COVID‐19: A Case Report With Literature Review

Sharma,

Islam,

Alam

et al. 2024

Clinical Case Reports

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Strongyloides hyperinfection and disseminated infections are usually associated with immunosuppression; these severe manifestations occur in a minority of cases. The use of immunosuppressants such as corticosteroids and Baricitinib for treating COVID‐19 pneumonia can be responsible for patients' immunosuppression and cause Strongyloides hyperinfection syndrome. The chance increases when the patient belongs to countries or regions where chronic infection with Strongyloides is more prevalent. This case report describes the clinical scenario of a 78‐year‐old man from southeastern Bangladesh who was initially diagnosed with COVID‐19 pneumonia. His condition improved after receiving corticosteroid therapy for approximately 1 month at various doses and Baricitinib therapy for more than a week due to moderate‐to‐severe COVID‐19 pneumonia. Approximately 2 months later, he presented with low‐grade fever, diarrhea, and itching throughout the body. Blood analysis revealed eosinophilia; stool examination revealed Rhabditiform larvae of Strongyloides stercoralis. The patient was diagnosed with Strongyloides hyperinfection syndrome and treated with Albendazole and Ivermectin. His clinical condition gradually improved, and he was discharged from the hospital. The stool sample was sent for a repeat microscopic examination after 14 days, which yielded a negative result. Clinicians should be more vigilant while prescribing corticosteroids and other immunosuppressants for a prolonged period. Proper screening to identify asymptomatic cases of strongyloidiasis, followed by empirical treatment of screening‐positive cases, prompt detection, and management of severe manifestations, is crucial to reduce further morbidity and mortality related to Strongyloides stercoralis.

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Strongyloides Hyperinfection Syndrome Following Immunosuppressant Therapy for COVID‐19: A Case Report With Literature Review

Sharma,

Islam,

Alam

et al. 2024

Clinical Case Reports

View full text Add to dashboard Cite

show abstract

Seroprevalence of Strongyloides stercoralis, human T-lymphotropic virus, and Chagas disease in the Peruvian Amazon: a cross-sectional study

Casapía-Morales,

Casanova-Rojas,

Vázquez-Ascate

et al. 2024

Rev. Inst. Med. trop. S. Paulo

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Strongyloides stercoralis infections, human T-lymphotropic virus (HTLV) infections, and Chagas diseases occur throughout many regions of Central and South America, including Peru. This study aimed to evaluate the seroprevalence of S. stercoralis , HTLV, and Chagas disease in Iquitos (Peruvian Amazon) and the associated epidemiological conditions for S. stercoralis seroprevalence in Iquitos. A population-based cross-sectional study was conducted from May 1 to June 15, 2020, to assess the seroprevalence of S. stercoralis [lysate antigen ELISA (enzyme linked immunosorbent assay)], HTLV (recombinant antigen ELISA), and Chagas disease (crude and recombinant antigen ELISAs). Of the 396 included individuals, 257 were seropositive for S. stercoralis (a 64.9% prevalence, 95% confidence interval [CI] 60.0% to 69.4%). In the multivariable analysis, seropositivity for S. stercoralis was higher in women (odds ratio [OR] 1.60, 95% CI 1.03 to 2.66) and residents of Punchana (OR 3.47, 95% CI 1.51 to 7.93), whereas residence in Iquitos was associated with lower positivity (OR 0.52, 95% CI 0.32 to 0.85). In total, four individuals were positive for HTLV (1.0% seroprevalence, 95% CI 0.3% to 2.7%), and none were positive for Chagas disease (0.0% seroprevalence, 95% CI 0.0% to 1.2%). The seroprevalence of S. stercoralis in Iquitos is high, particularly among women and residents of Punchana. The presence of HTLV infection indicates that the virus is circulating in Iquitos. This study found no cases of Chagas disease.

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High prevalence of anti-Strongyloides antibody in SARS-CoV-2-infected human sera in a Thai hospital: Rapid serological screening

Cited by 2 publications

References 11 publications

Strongyloides Hyperinfection Syndrome Following Immunosuppressant Therapy for COVID‐19: A Case Report With Literature Review

Strongyloides Hyperinfection Syndrome Following Immunosuppressant Therapy for COVID‐19: A Case Report With Literature Review

Seroprevalence of Strongyloides stercoralis, human T-lymphotropic virus, and Chagas disease in the Peruvian Amazon: a cross-sectional study

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