High Prevalence of Antimicrobial Resistance among
            <i>Shigella</i>
            Isolates in the United States Tested by the National Antimicrobial Resistance Monitoring System from 1999 to 2002

Sivapalasingam, Sumathi; Joyce, Kevin; Hoekstra, Robert M.; Angulo, Frederick J.; Mintz, Eric D.

doi:10.1128/aac.50.1.49-54.2006

Cited by 104 publications

(76 citation statements)

References 44 publications

(41 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Our study has proved that this antimicrobial is no longer appropriate for the treatment of shigellosis in Belgium. The same conclusion had already been reached a few years ago in the United States (21).…”

Section: Discussionsupporting

confidence: 64%

Surveillance of Antibiotic Susceptibility Patterns among Shigella sonnei Strains Isolated in Belgium during the 18-Year Period 1990 to 2007

Vrints¹,

Mairiaux

Meervenne³

et al. 2009

J Clin Microbiol

View full text Add to dashboard Cite

This study was conducted to determine the frequency and pattern of antimicrobial susceptibility of Shigella sonnei, the predominant species causing shigellosis in Belgium. Between 1990 and 2007, a total of 7,307 strains, mainly (98.2%) isolated from stools, were diagnosed by peripheral laboratories before being confirmed as Shigella strains by serotyping by the National Reference Center of Salmonella and Shigella. A significant increase in resistances to tetracycline, streptomycin, trimethoprim, sulfonamides, and cotrimoxazole (i.e., trimethoprim in combination with sulfonamides) was observed during this period. Since 1998, resistance to nalidixic acid also increased to reach a peak (12.8%) of resistant isolates in 2004. Concomitantly, multidrug resistance (MDR) in this species emerged in 2007, with 82% of total isolates being MDR. However, during this 18-year period, all isolates remained fully susceptible to ciprofloxacin and gentamicin. The work includes the molecular characterization of mechanisms of resistance to ampicillin, tetracycline, chloramphenicol, and cotrimoxazole and class 1 and class 2 integrons. S. sonnei acquired antimicrobial resistance to traditional antibiotics (ampicillin and tetracycline) by horizontal gene transfer, while the genetic stability of transposons was responsible for a high (89%) proportion of resistance to a commonly prescribed antibiotic (cotrimoxazole). Therefore, cotrimoxazole should no longer be considered appropriate as empirical therapy for treatment of shigellosis in Belgium when antibiotics are indicated. Rates of resistance to nalidixic acid should also be attentively monitored to detect any shift in fluoroquinolone resistance, because it represents the first line among antibiotics used in the treatment of shigellosis.

show abstract

Section: Discussionsupporting

confidence: 64%

Surveillance of Antibiotic Susceptibility Patterns among Shigella sonnei Strains Isolated in Belgium during the 18-Year Period 1990 to 2007

Vrints¹,

Mairiaux

Meervenne³

et al. 2009

J Clin Microbiol

View full text Add to dashboard Cite

show abstract

“…Among the different serogroups, only S. flexneri isolates (32.1%) were resistant to chloramphenicol, a finding which is consistent with that of a previous study conducted in North America [14]. This is an interesting observation because S. flexneri is no longer the predominant species in Iran as it was in the past [1,2].…”

supporting

confidence: 81%

Antibiotic resistance among Shigella serogroups isolated in Tehran, Iran (2002-2004)

Ranjbar

Dallal

Pourshafie

et al. 2009

J Infect Dev Ctries

View full text Add to dashboard Cite

show abstract

“…Overall, S. flexneri was more frequently resistant to most of the antibiotics than S. sonnei. One possible explanation is that infections due to S. sonnei are milder than infections due to the other S. flexneri, making exposure to selective pressure from antibiotics less likely (15,23,24). Fortunately, no resistance was found against ciprofloxacin and imipenem in our study.…”

Section: Discussionmentioning

confidence: 42%

Prevalence and Antibiotic Susceptibility of Shigella Species Isolated From Pediatric Patients in Tehran

Talebreza

Memariani

et al. 2015

Arch Pediatr Infect Dis

View full text Add to dashboard Cite

Background: Dysentery accounts for a significant proportion of morbidity and mortality cases, especially in children with diarrhea in developing countries. Shigellosis remains a public health problem in Iran. Objectives: The objectives of this study were to investigate the presence and the frequency of Shigella spp. among children younger than 10 years with diarrhea and to determine the antimicrobial resistance patterns of these isolates in Tehran, Iran. Patients and Methods: This cross-sectional study was conducted in two pediatric hospitals in Tehran, from October, 2013 to October, 2014. Nine hundred and thirty-eight (n = 938) stool samples were collected (one stool per patient) from children less than 10 years of age. The stools were primarily cultured on MacConkey agar and xylose lysine deoxycholate (XLD). (Selenite-F broth is also used as an enrichment medium for the isolation of Shigella spp.) All of the isolates were confirmed as Shigella species by biochemical and serological tests. Molecular confirmation of Shigella isolates was determined by polymerase chain reaction (PCR) using specific primers for the ipaH gene. The antibiotic susceptibility of the Shigella isolates was tested using the Kirby-Bauer disc-diffusion method. Results: Amongst 938 stool samples, 36 were Shigella spp. S. sonnei (61.1%, n = 22), which was the most common, followed by S. flexneri (27.8%, n = 10), S. boydii (8.3%, n = 3), and S. dysenteriae (2.8%, n = 1). Furthermore, most Shigella isolates showed resistance to amoxicillin (83.3%), tetracycline (61.1%), and co-trimoxazole (83.3%). No resistance was found against ciprofloxacin and imipenem. This study showed that S. sonnei is currently the predominant species in Tehran, Iran. Conclusions: Because resistance to antibiotics changes constantly, Shigella strains should be under surveillance in order to monitor local susceptibility and subsequently formulate policies for the use of antimicrobial drugs.

show abstract

High Prevalence of Antimicrobial Resistance among Shigella Isolates in the United States Tested by the National Antimicrobial Resistance Monitoring System from 1999 to 2002

Cited by 104 publications

References 44 publications

Surveillance of Antibiotic Susceptibility Patterns among Shigella sonnei Strains Isolated in Belgium during the 18-Year Period 1990 to 2007

Surveillance of Antibiotic Susceptibility Patterns among Shigella sonnei Strains Isolated in Belgium during the 18-Year Period 1990 to 2007

Antibiotic resistance among Shigella serogroups isolated in Tehran, Iran (2002-2004)

Prevalence and Antibiotic Susceptibility of Shigella Species Isolated From Pediatric Patients in Tehran

Contact Info

Product

Resources

About