High prevalence of asthma and atopy in the Canary Islands, Spain

Juliá-Serdà, Gabriel; Cabrera-Navarro, Pedro; Acosta-Fernández, Orlando; Martín-Pérez, P.; Losada-Cabrera, P.; Bello, Miguel Ángel García; Carrillo-Díaz, Teresa; Antó-Boqué, Josep

doi:10.5588/ijtld.10.0303

Cited by 18 publications

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“…However, so far there are no population-based studies providing information on sensitization to BT and its relation to asthma or other allergic diseases. In addition, in a previous study we reported a higher prevalence of asthma in the Canaries than in the other Spanish centers in the ECRHS, something that was attributed to the temperate climate of the region (6). In order to address this lack of information, and applying the same methodology used in the ECRHS, in this study, we have analyzed the prevalence of sensitization to BT in the Canaries in a random sample of adult subjects, aged 20-44, and its relation to asthma, asthma-related symptoms, rhinitis, and atopic dermatitis.…”

Section: Introductionmentioning

confidence: 87%

Prevalence of Sensitization toBlomia tropicalisamong Young Adults in a Temperate Climate

et al. 2012

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Section: Introductionmentioning

confidence: 87%

Prevalence of Sensitization toBlomia tropicalisamong Young Adults in a Temperate Climate

et al. 2012

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“…The Canary Islands have a very high incidence of allergic diseases. Although allergic comorbidity is a multifactorial pathology, the existence of other unknown factors that influence the high incidence in the Canaries is recognized [ 10 , 11 ].…”

Section: Discussionmentioning

confidence: 99%

“…The prevalence of asthmatic adults in the Canary Islands is significantly higher when compared to the national average (17.2% and 5.7%, respectively) [ 9 , 10 , 11 , 12 ]. In children, results are similar and prevalence of asthma (18.4%), rhinitis (40.3%) and allergic dermatitis (35.8%) are higher than the national averages [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

“…In children, results are similar and prevalence of asthma (18.4%), rhinitis (40.3%) and allergic dermatitis (35.8%) are higher than the national averages [ 13 ]. In general, the prevalence of allergic diseases in the Canary Islands is among the highest globally and it is believed that allergic individuals are being underdiagnosed [ 11 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

“…On the other hand, the trade winds free the archipelago from excessive urban pollution together with the fact that industrialization is much lower than in other Spanish continental regions [ 10 , 14 ]. However, it is recognized that there are other as-yet-unknown factors that influence the high incidence of these pathologies in the Canary Islands [ 11 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

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Dirofilaria immitis Could Be a Risk Factor for the Development of Allergic Diseases in Humans

Montoya-Alonso

Morchón

Matos

et al. 2020

Animals

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The Canary Islands are hyperendemic for canine heartworm and the risk of zoonotic infection is high. Additionally, there is evidence of development of allergies due to nematode infections in animals and humans. Since the population of the Canary Islands presents high prevalence of allergic comorbidities, and previous studies have shown a possible relationship between allergies and seropositivity to heartworm, the aim was to evaluate whether exposure to heartworm may contribute to the development of allergies in the human population. First, an epidemiological study was conducted on 248 owners of dogs with/without heartworm infection in the Canary Islands. Secondly, a serological analysis of the presence of total IgE and specific IgE against heartworm was conducted in 66 samples of inhabitants of the Canary Islands. The survey showed that allergic owners had heartworm-positive dogs more frequently (p < 0.01). Of the analyzed human samples, 43.9% were seropositive to heartworm and Wolbachia. Total IgE concentrations were increased in 34.5% seropositive samples and 8.1% seronegative samples. Specific IgE against heartworm was only found in human seropositive samples (17.2%). Contact with heartworm may be a risk factor for the development of allergic diseases, although further studies to elucidate the relationship between heartworm and allergies should be carried out.

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No association between genetic ancestry and susceptibility to asthma or atopy in Canary Islanders

et al. 2012

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Asthma is a complex respiratory disease characterized by chronic inflammation of airways and frequently associated with atopic symptoms. The population from the Canary Islands, which has resulted from a recent admixture of North African and Iberian populations, shows the highest prevalence of asthma and atopic symptoms among the Spanish populations. Although environmental particularities would account for the majority of such disparity, genetic ancestry might play a role in increasing the susceptibility of asthma or atopy, as have been demonstrated in other recently African-admixed populations. Here, we aimed to explore whether genetic ancestry was associated with asthma or related traits in the Canary Islanders. For that, a total of 734 DNA samples from unrelated individuals of the GOA study, self-reporting at least two generations of ancestors from the Canary Islands (391 asthmatics and 343 controls), were successfully genotyped for 83 ancestry informative markers (AIMs), which allowed to precisely distinguishing between North African and Iberian ancestries. No association was found between genetic ancestry and asthma or related traits after adjusting by demographic variables differing among compared groups. Similarly, none of the individual AIMs was associated with asthma when results were considered in the context of the multiple comparisons performed (0.005 ≤ p value ≤ 0.042; 0.221 ≤ q value ≤ 0.443). Our results suggest that if genetic ancestry were involved in the susceptibility to asthma or related traits among Canary Islanders, its effects would be modest. Larger studies, examining more genetic variants, would be needed to explore such possibility.

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High prevalence of asthma and atopy in the Canary Islands, Spain

Abstract: This study shows a high prevalence of sensitisation to mites, atopy, BHR and asthma in the Canaries, similar to that observed in English-speaking countries. We suggest that these findings could partially result from climatic conditions.

Cited by 18 publications

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Prevalence of Sensitization toBlomia tropicalisamong Young Adults in a Temperate Climate

Prevalence of Sensitization toBlomia tropicalisamong Young Adults in a Temperate Climate

Dirofilaria immitis Could Be a Risk Factor for the Development of Allergic Diseases in Humans

No association between genetic ancestry and susceptibility to asthma or atopy in Canary Islanders

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