High prevalence of atrophic body gastritis in patients with unexplained microcytic and macrocytic anemia A prospective screening study

Marignani, Massimo; Fave, Gianfranco Delle; Mecarocci, Sergio; Bordi, Cesare; Angeletti, Stefano; D’Ambra, G.; Aprile, M; Corleto, Vito D.; Monarca, Bruno; Annibale, Bruno

doi:10.1016/s0002-9270(99)00004-0

Cited by 72 publications

(82 citation statements)

References 30 publications

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“…Criteria for the diagnosis of ABG: The diagnosis of ABG was based on the presence of fasting gastrin above upper normal values, and histological confirmation of gastric body mucosal atrophy, as previously described [24,25] . Briefly, all patients underwent gastroscopy with standardized biopsy sampling from the antrum (n = 3), body (n = 3) for conventional histopathological examination [24,25] .…”

Section: Patientsmentioning

confidence: 99%

“…Briefly, all patients underwent gastroscopy with standardized biopsy sampling from the antrum (n = 3), body (n = 3) for conventional histopathological examination [24,25] . The degree of gastritis was assessed according to the updated Sydney System [26] .…”

Section: Patientsmentioning

confidence: 99%

“…The degree of gastritis was assessed according to the updated Sydney System [26] . Atrophy of the body and antral mucosa was defined as focal or complete replacement of oxyntic or pyloric glands by metaplastic pyloric or intestinal glands, respectively [24,25] . Furthermore, all patients underwent serological studies: fasting gastrin levels were evaluated by means of a specific radioimmunoassay (RIA) using polyclonal antibody No.…”

Section: Patientsmentioning

confidence: 99%

“…Furthermore, all patients underwent serological studies: fasting gastrin levels were evaluated by means of a specific radioimmunoassay (RIA) using polyclonal antibody No. 4562 [24,25] . PepsinogenⅠlevels were measured using a commercial RIA kit (Pepsik, Sorin, Saluggia, Italy) [25] .…”

Section: Patientsmentioning

confidence: 99%

“…PepsinogenⅠlevels were measured using a commercial RIA kit (Pepsik, Sorin, Saluggia, Italy) [25] . Antibodies against anti-parietal cells were assayed using a commercial kit (Autostat, Cogent Diagnostic Ltd, Edinburgh, UK) [24,25] .…”

Section: Patientsmentioning

confidence: 99%

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Artificial neural networks in the recognition of the presence of thyroid disease in patients with atrophic body gastritis

Lahner¹,

Intraligi²,

Buscema³

et al. 2008

WJG

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AIM:To investigate the role of artificial neural networks in predicting the presence of thyroid disease in atrophic body gastritis patients. METHODS:A dataset of 29 input variables of 253 atrophic body gastritis patients was applied to artificial neural networks (ANNs) using a data optimisation procedure (standard ANNs, T&T-IS protocol, TWIST protocol). The target variable was the presence of thyroid disease. RESULTS:Standard ANNs obtained a mean accuracy of 64.4% with a sensitivity of 69% and a specificity of 59.8% in recognizing atrophic body gastritis patients with thyroid disease. The optimization procedures (T&T-IS and TWIST protocol) improved the performance of the recognition task yielding a mean accuracy, sensitivity and specificity of 74.7% and 75.8%, 78.8% and 81.8%, and 70.5% and 69.9%, respectively. The increase of sensitivity of the TWIST protocol was statistically significant compared to T&T-IS. CONCLUSION:This study suggests that artificial neural networks may be taken into consideration as a potential clinical decision-support tool for identifying ABG patients at risk for harbouring an unknown thyroid disease and thus requiring diagnostic work-up of their thyroid status.

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Section: Patientsmentioning

confidence: 99%

Section: Patientsmentioning

confidence: 99%

Section: Patientsmentioning

confidence: 99%

Section: Patientsmentioning

confidence: 99%

Section: Patientsmentioning

confidence: 99%

See 3 more Smart Citations

Artificial neural networks in the recognition of the presence of thyroid disease in patients with atrophic body gastritis

Lahner¹,

Intraligi²,

Buscema³

et al. 2008

WJG

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Atrophic Body Gastritis in Patients With Autoimmune Thyroid Disease

Centanni¹,

Marignani²,

Gargano³

et al. 1999

Arch Intern Med

156

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Significance of Endoscopy in Asymptomatic Premenopausal Women with Iron Deficiency Anemia

Park

Ryu

et al. 2006

Dig Dis Sci

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There is, currently, no consensus with regard to the role of endoscopy in the etiologic investigation of asymptomatic pemenopausal women suffering from iron deficiency anemia (IDA). We conducted a retrospective case-control study to evaluate the contribution of esophagogastroduodenoscopy (EGD) and colonoscopy to the etiologic diagnosis of a group of asymptomatic premenopausal women suffering from IDA. One hundred eight consecutive asymptomatic premenopausal women who fulfilled our entry criteria were included in our patient group between January 1998 and December 2004. One hundred thirty-five age-matched asymptomatic premenopausal women without anemia who had undergone EGD and colonoscopy for medical checkups were included in the control group. Clinically relevant lesions were detected in 7 of 108 (6.5%) of the patients and in 8 of 135 (5.9%) of the controls. There were no differences with regard to the frequency of clinically relevant lesions between the two groups (P > 0.05). Concomitant upper and lower GI lesions were not detected in any patients. In the upper GI tract, the only lesion found to be potentially causative of IDA anemia was a severe erosive gastritis, which was found in both the patient and the control groups. A source consistent with chronic bleeding was detected in the lower GI tract in 6 (5.6%) of the patients and 7 (5.2%) of the controls. Bleeding hemorrhoids represented the most frequently detected lesions in both the patient and control groups. Only one case of colon cancer was detected in the patient group. As IDA in the premenopausal women could not be attributed consistently to GI blood loss in this study, prospective studies should be conducted to validate our findings and to identify which subgroup of asymptomatic premenopausal women would benefit from a diagnostic endoscopic evaluation.

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High prevalence of atrophic body gastritis in patients with unexplained microcytic and macrocytic anemia A prospective screening study

Abstract: Macrocytic anemia is not the only hematological presentation of ABG. Physicians evaluating patients with unexplained iron deficiency anemia should consider ABG as a possible cause by determining fasting gastrin levels and performing gastroscopy with biopsies of the body mucosa.

Cited by 72 publications

References 30 publications

Artificial neural networks in the recognition of the presence of thyroid disease in patients with atrophic body gastritis

Artificial neural networks in the recognition of the presence of thyroid disease in patients with atrophic body gastritis

Atrophic Body Gastritis in Patients With Autoimmune Thyroid Disease

Significance of Endoscopy in Asymptomatic Premenopausal Women with Iron Deficiency Anemia

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