High prevalence of autoimmune diseases in women with endometriosis: a case-control study

Porpora, Maria Grazia; Scaramuzzino, Sara; Sangiuliano, Chiara; Piacenti, Ilaria; Bonanni, Valentina; Piccioni, Maria Grazia; Ostuni, Renato; Masciullo, Luisa; Panici, P. L. Benedetti

doi:10.1080/09513590.2019.1655727

Cited by 41 publications

(30 citation statements)

References 30 publications

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“…There were 80 cases of thyroiditis in the case group (54,4%) and fourteen controls (9,3%) (OR=11.37; 95%CI 6-21.5; p<0.0001). This significant association between endometriosis and other autoimmune diseases supports the assumption of autoimmune background of endometriosis [15].…”

Section: Risk Factors Immune and Hormonal Abnormalitiessupporting

confidence: 74%

Endometriosis and ovarian cancer - what they have in common?

Zarankiewicz

Kosz

Kuchnicka

et al. 2020

J Educ Health Sport

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Introduction and purpose: Endometriosis is one of the most common diseases among women in the reproductive age. Although its etiology remains not fully understood, several models of endometriosis development are taken into consideration. Many studies have been focused on hormonal and genetic alterations in endometriosis. The results of these studies allow for a thesis on common origin of endometriosis and a few types of ovarian cancer. The aim of this review is to present actual knowledge about endometriosis' development conditions and a possible association with ovarian cancer. Material and method: The review concerned articles published in years 2012-2020, which were collected in the PubMed and Google Scholar. Particular attention was paid to the development of both the endometriosis and Endometriosis-Related Ovarian Neoplasms (ERONs) and their genetic disorders. Results: Endometriosis development is connected with several risk factors and also immune, hormonal and genetic alterations. Some authors postulated that malignant transformation of endometriosis may be a multi-step process powered by increasing levels of estrogen. Many studies confirmed that mutations of ARID1A and PIK3CA genes are likely to be present in the majority of cases of ovarian cancer with adjacent endometriosis. Conclusions: The awareness of clinical features and medical complications of endometriosis is spreading increasingly around the world. Many studies are focused on genetic causes of this illness. It may be supposed that we will be able to select women with endometriosis and increased risk of ovarian cancer and prevent its development.

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Section: Risk Factors Immune and Hormonal Abnormalitiessupporting

confidence: 74%

Endometriosis and ovarian cancer - what they have in common?

Zarankiewicz

Kosz

Kuchnicka

et al. 2020

J Educ Health Sport

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“…Despite the fact that retrograde menstruation is a known and common phenomenon regularly seen in women during laparoscopic procedures, only 10-15% of all women develop EM during their reproductive phase of life [3]. Therefore, other factors such as the type of cells that are translocated into the abdominal cavity, the immune system, genetic and epigenetic processes, as well as environmental factors play a role [4,5]. The occurrence of primary umbilical EM is explained by the reactivation of the coeloma residuals that remain in the navel as a result of the physiological omphaloceles.…”

Section: Pathogenesis Of Endometriotic Lesionsmentioning

confidence: 99%

Pathogenesis of Endometriosis: The Origin of Pain and Subfertility

Gruber

Mechsner

2021

Cells

109

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Endometriosis (EM) and adenomyosis (AM) are common conditions with pain and infertility as the principal symptoms. The pathophysiology of pain in EM and AM comprises sensory and somatoform pain mechanisms. Over time, these may aggravate and lead to individual complex disease patterns if not diagnosed and treated. Despite the known facts, several years often pass between the onset of symptoms and diagnosis. Chronic pain disorders with changes on a neuronal level frequently arise and are linked to depressive disorders, with the process becoming a vicious cycle. Additionally, women with EM and AM suffer from sub- and infertility. Low fecundity rates are caused by anatomical changes in combination with behavioral changes in the sexual activity of women with chronic pain as well as local proinflammatory factors that not only decrease implantation rates but also promote early abortions.

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“…It has been shown that abnormally activated B lymphocytes may be involved in induction of autoimmune response in patients suffering from endometriosis [54]. In particular, antigen presenting cells (APC), which present endometrial self-antigens to autoreactive T and B cells, play an important role in this response.…”

Section: Mdscs Influence B Cell Functionmentioning

confidence: 99%

“…Interestingly, an increased level of anti-endometrial antibodies has been detected in the serum of EMS patients [55,56]. Moreover, studies have shown that women with endometriosis have a greater risk of several autoimmune diseases than EMS-unaffected women [54,55]. Recent studies have demonstrated an association between endometriosis and increased risk of some autoimmune diseases, e.g., systemic lupus erythematosus (SLE), Sjogren's syndrome (SS), celiac disease (CLD), multiple sclerosis (MS), and inflammatory bowel disease (IBD).…”

Section: Mdscs Influence B Cell Functionmentioning

confidence: 99%

The Role of Myeloid-Derived Suppressor Cells (MDSCs) in the Development and/or Progression of Endometriosis-State of the Art

Suszczyk

Skiba

Jakubowicz-Gil

et al. 2021

Cells

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Endometriosis (EMS) is a common gynecological disease characterized by the presence of endometrial tissue outside the uterus. Approximately 10% of women around the world suffer from this disease. Recent studies suggest that endometriosis has potential to transform into endometriosis-associated ovarian cancer (EAOC). Endometriosis is connected with chronic inflammation and changes in the phenotype, activity, and function of immune cells. The underlying mechanisms include quantitative and functional disturbances of neutrophils, monocytes/macrophages (MO/MA), natural killer cells (NK), and T cells. A few reports have shown that immunosuppressive cells such as regulatory T cells (Tregs) and myeloid-derived suppressor cells (MDSCs) may promote the progression of endometriosis. MDSCs are a heterogeneous population of immature myeloid cells (dendritic cells, granulocytes, and MO/MA precursors), which play an important role in the development of immunological diseases such as chronic inflammation and cancer. The presence of MDSCs in pathological conditions correlates with immunosuppression, angiogenesis, or release of growth factors and cytokines, which promote progression of these diseases. In this paper, we review the impact of MDSCs on different populations of immune cells, focusing on their immunosuppressive role in the immune system, which may be related with the pathogenesis and/or progression of endometriosis and its transformation into ovarian cancer.

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High prevalence of autoimmune diseases in women with endometriosis: a case-control study

Cited by 41 publications

References 30 publications

Endometriosis and ovarian cancer - what they have in common?

Endometriosis and ovarian cancer - what they have in common?

Pathogenesis of Endometriosis: The Origin of Pain and Subfertility

The Role of Myeloid-Derived Suppressor Cells (MDSCs) in the Development and/or Progression of Endometriosis-State of the Art

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