High prevalence of candiduria due to non‐<i>albicans Candida</i> species among diabetic patients: A matter of concern?

Esmailzadeh, Alireza; Zarrinfar, Hossein; Fata, Abdolmajid; Sen, Tanuka

doi:10.1002/jcla.22343

Cited by 47 publications

(40 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Since the 1980s, there has been a marked increase in opportunistic fungal infections involving the urinary tract, of which C. albicans is the most commonly isolated species, but NCAC sp. is now the majority in many countries worldwide [275,276]. Candiduria (presence of Candida sp.…”

Section: Candidiasis and Dmmentioning

confidence: 99%

“…The study concluded that when considering the high incidence rate of candiduria in diabetic patients, the control of diabetes, predisposing factors, and causal relationships between diabetes and candiduria should be highlighted [277]. In a 2018 study, Esmailzadeh et al [276] evaluated candiduria among type 2 diabetic patients. Indeed, the results showed that the rate of candiduria was relatively high in type 2 diabetic patients and they were also suffering from a lack of proper blood glucose control.…”

Section: Candidiasis and Dmmentioning

confidence: 99%

See 1 more Smart Citation

Candida sp. Infections in Patients with Diabetes Mellitus

Rodrigues

Henriques

2019

JCM

211

161

View full text Add to dashboard Cite

Candidiasis has increased substantially worldwide over recent decades and is a significant cause of morbidity and mortality, especially among critically ill patients. Diabetes mellitus (DM) is a metabolic disorder that predisposes individuals to fungal infections, including those related to Candida sp., due to a immunosuppressive effect on the patient. This review aims to discuss the latest studies regarding the occurrence of candidiasis on DM patients and the pathophysiology and etiology associated with these co-morbidities. A comprehensive review of the literature was undertaken. PubMed, Scopus, Elsevier’s ScienceDirect, and Springer’s SpringerLink databases were searched using well-defined search terms. Predefined inclusion and exclusion criteria were applied to classify relevant manuscripts. Results of the review show that DM patients have an increased susceptibility to Candida sp. infections which aggravates in the cases of uncontrolled hyperglycemia. The conclusion is that, for these patients, the hospitalization periods have increased and are commonly associated with the prolonged use of indwelling medical devices, which also increase the costs associated with disease management.

show abstract

Section: Candidiasis and Dmmentioning

confidence: 99%

Section: Candidiasis and Dmmentioning

confidence: 99%

Candida sp. Infections in Patients with Diabetes Mellitus

Rodrigues

Henriques

2019

JCM

211

161

View full text Add to dashboard Cite

show abstract

“…The oral cavity, gastrointestinal tract, and other mucous membranes are the hosts of C. albicans, with other yeasts growing as the normal flora, leading to hematogenous seeding with yeast cells when the immune system is suppressed. According to epidemiological studies, non-albicans Candida species including C. tropicalis, C. parapsilosis, C. krusei, and C. glabrata have repeatedly emerged as human pathogens (3,4).…”

Section: Introductionmentioning

confidence: 99%

Comparison of Virulence Factors of Different Candida Species Isolated from the Oral Cavity of Cancer Patients and Normal Individuals

Maheronnaghsh

Fatahinia

Dehghan

et al. 2019

Jundishapur J Microbiol

View full text Add to dashboard Cite

Background: Candida yeast is a normal flora of the mucous membrane of the oral cavity. Various enzymes secreted by Candida species play the role of virulence factors in different Candida infections including in cancer patients. Objectives: This study aimed at comparing phospholipase, proteinase, esterase, and hemolytic activities in different Candida species isolated from the oral cavity of cancer patients and normal people. Methods: This study was conducted on 36 cancer patients and 36 healthy people. MspI restriction enzyme for PCR-RFLP method was used to identify the Candida species. The enzymatic activity index (EAI) was measured for each enzyme using the relevant protocols. Results: Candida albicans was the most frequent species with the frequency of 26 (72%) and 31 (81.1%) in cancer patients and healthy people, respectively. In healthy individuals and patients, the mean phospholipase activity of Candida isolates was 0.795 and 0.775, proteinase activity was 0.7531 and 0.7558, esterase activity was 0.6142 and 0.7186, and hemolysin activity was 0.6317 and 0.5756, respectively. Conclusions:The results showed that C. albicans was the most frequent Candida species isolated from healthy people and patients. Phospholipase, proteinase, and hemolysin activity of Candida species was higher in patients than in healthy people and hemolytic activity was significantly higher in patients than in healthy subjects (P < 0.05). However, Candida species in both groups were positive for esterase activity but the mean activity of this enzyme was significantly higher in the healthy group than in the patient group.

show abstract

“…Candida glabrata is an emerging human fungal pathogen, ranking as the second or third common cause of clinical forms of candidosis (1)(2)(3), highlighting bloodstream infections due to its unacceptable high mortality rate ranging from 58% to 61% (4). Furthermore, C. glabrata is a species complex comprised of C. glabrata sensu stricto, C. nivariensis, and C. bracarensis (5,6).…”

Section: Introductionmentioning

confidence: 99%

In Vitro Determination of Hydrolytic Enzymes and Echinocandin Susceptibility in Mexican Clinical Isolates of Candida glabrata Sensu Stricto

Treviño-Rangel

Espinosa-Pérez²,

Villanueva-Lozano

et al. 2019

Jundishapur J Microbiol

View full text Add to dashboard Cite

Background: Candida glabrata is an opportunistic yeast that has emerged as a cause of human fungal disease, and is a complex of three closely related species. Until now, there is not enough information about its virulence attributes. Moreover, its resistance to echinocandins has been documented, which is a cause of clinical concern. Objectives: The objective of this study was to evaluate the in vitro production of aspartyl proteinase, phospholipase, esterase, hemolysin, DNase, and coagulase in a subset of 107 Mexican clinical isolates of C. glabrata sensu stricto, as well as to determinate its echinocandin susceptibility. Methods: The enzymatic determinations were carried out in plate assays using specific substrates, excepting coagulase, which was determined by the classic tube test. Antifungal susceptibility testing was determined in accordance with the CLSI broth microdilution method. Results: Aspartyl proteinase, hemolysin, and phospholipase were detected in 100%, 95%, and 79% of isolates, respectively. Blood isolates were associated with a very strong activity of aspartyl proteinase and hemolysin, and those recovered from vaginal swabs were associated with very strong production of aspartyl proteinase, phospholipase, and hemolysin. All isolates were susceptible to echinocandins, except one bloodstream isolate, which was resistant to echinocandins. Conclusions: A very strong activity of aspartyl proteinase and hemolysin was particularly associated with both, bloodstream, and vaginal swab isolates. Echinocandin resistance was rare.

show abstract

High prevalence of candiduria due to non‐albicans Candida species among diabetic patients: A matter of concern?

Cited by 47 publications

References 26 publications

Candida sp. Infections in Patients with Diabetes Mellitus

Candida sp. Infections in Patients with Diabetes Mellitus

Comparison of Virulence Factors of Different Candida Species Isolated from the Oral Cavity of Cancer Patients and Normal Individuals

In Vitro Determination of Hydrolytic Enzymes and Echinocandin Susceptibility in Mexican Clinical Isolates of Candida glabrata Sensu Stricto

Contact Info

Product

Resources

About