2022
DOI: 10.3389/fendo.2022.938633
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High Prevalence of Common Human Viruses in Thyroid Tissue

Abstract: IntroductionEvidence points to viral infections as possible triggers of autoimmune thyroid disease (AITD), but little is known about the prevalence of common viruses in the thyroid gland. Using a novel approach based on virus enrichment in multiple cell lines followed by detection of the viral genome and visualization of viral proteins, we investigated the presence of multiple human viruses in thyroid tissue from AITD patients and controls.MethodsThyroid tissue was collected by core needle biopsy or during thy… Show more

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Cited by 21 publications
(14 citation statements)
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“…The role of viruses in inducing HT has been explored but it is still not completely determined [51,73,74]. New data are coming up about roles of DNA and RNA viruses to trigger HT [75][76][77].…”
Section: Discussionmentioning
confidence: 99%
“…The role of viruses in inducing HT has been explored but it is still not completely determined [51,73,74]. New data are coming up about roles of DNA and RNA viruses to trigger HT [75][76][77].…”
Section: Discussionmentioning
confidence: 99%
“…The role of viruses in inducing HT has been explored, but it is still not completely determined [ 52 , 74 , 75 ]. New data is becoming available regarding the roles of DNA and RNA viruses in triggering HT [ 76 , 77 ].…”
Section: Discussionmentioning
confidence: 99%
“…It is of interest that HHV-6 and parvovirus B19, two viral agents prevalent in the thyroid tissue [45] could not be detected in the pancreas. This confirms the specific pancreatic tropism of EVs [46] and that their link with type 1 diabetes is not by chance.…”
Section: Discussionmentioning
confidence: 99%