High prevalence of diabetes mellitus and metabolic syndrome in a South African coloured population: Baseline data of a study in Bellville, Cape Town

No evidence for association of insulin receptor substrate-1 Gly972Arg variant with type 2 diabetes mellitus in a mixed-ancestry population of South Africa

“…[16,17] Instead, a genetic variant, rs294361, located near IRS1 was associated with T2DM in a large-scale study of French and Danish individuals. [17] Similarly, these associations have not been found [18] in populations with a high prevalence of diabetes such as ours [8] and Pima Indians. [20] Jellema et al [15] investigated some of these factors, including ethnicity, type of study, diagnostic test used to confirm the presence of diabetes, type of measurement of the polymorphism, prevalence of the polymorphism and age.…”

“…[8,9] Briefly, eligible participants were invited to take part in a community-based survey from January 2008 to March 2009 (cohort 1), and January to November 2011 (cohort 2) in Bellville South, Cape Town, SA. The study was approved by the research ethics committees of Stellenbosch University and the Faculty of Health and Wellness Sciences, Cape Peninsula University of Technology.…”

“…Power calculation was performed with CaTS, [14] assuming a diabetes prevalence of 28%, [8] a Gly972Arg frequency of 19%, [2] a genotype odds ratio of 1.25 [15] under an additive model and a nominal p-value of <0.05. Based on the above, our population of 224 diabetic and 619 non-diabetic patients provided a statistical power of 60% for a onestage design.…”

Editor's choice

“…Mirroring the documented extremely high prevalence of type 2 diabetes in the South African Indian population, Erasmus et al 8 offer the startling insights that a third of adults of mixed ancestry in the Western Cape have the disorder, and that more than half of affected persons are unaware of their condition. So, the predicted epidemic in developing countries is upon us.…”

Turning nutrition on its head – Noakes gets his day

“…Bond cited a 2012 study in a coloured community in Bellville, Cape Town, [1] showing the prevalence of type 2 diabetes to be 28.2%, with 88% of affected females and 42% of affected males being obese according to waist measurement. A full 55% were undiagnosed, despite nearby healthcare facilities.…”