High prevalence of emphysema and its association with BMI: A study of smokers with normal spirometry

Stratelis, Georgios; Fransson, Sven-Göran; Schmekel, Birgitta; Jakobsson, Per; Mölstad, Sigvard

doi:10.1080/02813430802452732

Cited by 15 publications

(10 citation statements)

References 32 publications

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“…These results were in line with the observation described by Martinez that most males and patients with lower BMI had emphysematous forms of COPD, 25,26 whereas most females had asthmatic bronchitis. HRCT provides visual COPD phenotypes, which reflect the pathologic changes indirectly.…”

Section: Discussionsupporting

confidence: 92%

Pulmonary Function Parameters in High-resolution Computed Tomography Phenotypes of Chronic Obstructive Pulmonary Disease

Sun

Shen

Wan

et al. 2015

The American Journal of the Medical Sciences

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Section: Discussionsupporting

confidence: 92%

Pulmonary Function Parameters in High-resolution Computed Tomography Phenotypes of Chronic Obstructive Pulmonary Disease

Sun

Shen

Wan

et al. 2015

The American Journal of the Medical Sciences

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“…Expectedly, the patients with high SI values had frail build with lower BMI values especially in patients with emphysema-predominant phenotype, and the correlation between the two variables was found to be statistically significant. This observation is in corroboration with previous studies, which showed similar correlation between BMI and emphysema [6,7].…”

Section: Discussionsupporting

confidence: 93%

Quantitative assessment of airway and parenchymal components of chronic obstructive pulmonary disease using thin-section helical computed tomography

Chauhan¹,

Sood²,

Takkar³

et al. 2019

Pol J Radiol

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Purpose The purpose of this study was to diagnose and characterise chronic obstructive pulmonary disease (COPD) into its forms, patterns, and severity using MDCT. Material and methods In this prospective study, spirometric and MDCT evaluation was done in 52 consecutive patients diagnosed with COPD. In each patient six segmental bronchi were evaluated for CT morphometric indices of bronchial wall thickness (BWT) and wall area percentage (WAP). Quantitative evaluation of emphysema was done using inbuilt software, and volume of emphysematous lung was determined using percentage low attenuation area (LAA). COPD was categorised into the following: emphysema predominant; airway predominant; or mixed phenotypes, and severity grading was assigned as mild, moderate, or severe. Results Centrilobular was the predominant emphysema pattern occurring alone (36.5%) or in combination with paraseptal changes (34.6%). Among COPD phenotypes, emphysema predominant was the commonest (44.3%), followed by mixed (30.8%), and bronchitis predominant (25.0%). The mean BWT in the airway-predominant group was significantly higher (1.94 ± 0.28 mm) than in the emphysema-predominant subgroup (1.79 ± 0.23 mm) with a p value of 0.005. Conclusion MDCT is an indispensable tool in quantitative and qualitative evaluation of COPD patients. Measurement of CT indices like BWT, WAP, and %LAA can reliably categorise COPD into phenotypes like emphysema predominant, airway predominant, or mixed, which serve as a guide for patient management.

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“…Although we performed five association analyses, we reported unadjusted P values, as our phenotypes are correlated, and some of our findings are seen in multiple phenotypes. Quantitative imaging can be affected by factors not related to intrinsic lung pathology, such as degree of inflation, obesity, smoking, and characteristics of individual CT scanners (5,64,65). Our decision to adjust for specific covariates was based on a desire to maximize findings of genetic analysis by controlling for the influence of age, smoking, and effects of individual scanners, yet allowing for genetic effects that may affect disease processes contributing to more than one characteristic (e.g., low body mass index and emphysema [66]).…”

Section: Original Articlementioning

confidence: 99%

A Genome-Wide Association Study of Emphysema and Airway Quantitative Imaging Phenotypes

Cho

Castaldi²,

Hersh

et al. 2015

Am J Respir Crit Care Med

138

126

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Rationale: Chronic obstructive pulmonary disease (COPD) is defined by the presence of airflow limitation on spirometry, yet subjects with COPD can have marked differences in computed tomography imaging. These differences may be driven by genetic factors. We hypothesized that a genome-wide association study (GWAS) of quantitative imaging would identify loci not previously identified in analyses of COPD or spirometry. In addition, we sought to determine whether previously described genome-wide significant COPD and spirometric loci were associated with emphysema or airway phenotypes.Objectives: To identify genetic determinants of quantitative imaging phenotypes.Methods: We performed a GWAS on two quantitative emphysema and two quantitative airway imaging phenotypes in the COPDGene (non-Hispanic white and African American), ECLIPSE (Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints), NETT (National Emphysema Treatment Trial), and GenKOLS (Genetics of COPD, Norway) studies and on percentage gas trapping in COPDGene. We also examined specific loci reported as genomewide significant for spirometric phenotypes related to airflow limitation or COPD. Measurements and Main Results:The total sample size across all cohorts was 12,031, of whom 9,338 were from COPDGene. We identified five loci associated with emphysema-related phenotypes, one with airway-related phenotypes, and two with gas trapping. These loci included previously reported associations, including the HHIP, 15q25, and AGER loci, as well as novel associations near SERPINA10 and DLC1. All previously reported COPD and a significant number of spirometric GWAS loci were at least nominally (P , 0.05) associated with either emphysema or airway phenotypes.Conclusions: Genome-wide analysis may identify novel risk factors for quantitative imaging characteristics in COPD and also identify imaging features associated with previously identified lung function loci.

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High prevalence of emphysema and its association with BMI: A study of smokers with normal spirometry

Cited by 15 publications

References 32 publications

Pulmonary Function Parameters in High-resolution Computed Tomography Phenotypes of Chronic Obstructive Pulmonary Disease

Pulmonary Function Parameters in High-resolution Computed Tomography Phenotypes of Chronic Obstructive Pulmonary Disease

Quantitative assessment of airway and parenchymal components of chronic obstructive pulmonary disease using thin-section helical computed tomography

A Genome-Wide Association Study of Emphysema and Airway Quantitative Imaging Phenotypes

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