High Prevalence of Fluoroquinolone-Resistant Group B Streptococci among Clinical Isolates in China and Predominance of Sequence Type 19 with Serotype III

Wang, Hui; Zhao, Chunjiang; He, Wenqiang; Zhang, Feifei; Zhang, Liyan; Cao, Bin; Sun, Ziyong; Xu, Yingchun; Yang, Qing; Mei, Yaning; Hu, Bijie; Chu, Yunzhuo; Liao, Kang; Yu, Yunsong; Hu, Zhidong; Ni, Yizhao

doi:10.1128/aac.02317-12

Cited by 37 publications

(40 citation statements)

References 27 publications

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“…It has also been reported (Wang et al, 2013) that ST19 is associated with serotypes Ib, II, III, and IV, but we found mostly serotype III strains, along with a few serotype V strains in our research, and this is likely the reason that ST19 was mostly associated with serotype III in our study. The isolates belonging to the same clonal groups and/or serotypes were clustered in the same or approaching PFGE clusters.…”

Section: Discussionsupporting

confidence: 59%

Molecular Characterization of Streptococcus agalactiae Causing Community- and Hospital-Acquired Infections in Shanghai, China

Jiang

Chen

et al. 2016

Front. Microbiol.

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Streptococcus agalactiae, a colonizing agent in pregnant women and the main cause of neonatal sepsis and meningitis, has been increasingly associated with invasive disease in nonpregnant adults. We collected a total of 87 non-repetitive S. agalactiae isolates causing community-acquired (CA) and hospital-acquired (HA) infections in nonpregnant adults from a teaching hospital in Shanghai between 2009 and 2013. We identified and characterized their antibiotic resistance, sequence type (ST), serotype, virulence, and biofilm formation. The most frequent STs were ST19 (29.9%), ST23 (16.1%), ST12 (13.8%), and ST1 (12.6%). ST19 had significantly different distributions between CA- and HA-group B Streptococci (GBS) isolates. The most frequent serotypes were III (32.2%), Ia (26.4%), V (14.9%), Ib (13.8%), and II (5.7%). Serotype III/ST19 was significantly associated with levofloxacin resistance in all isoates. The HA-GBS multidrug resistant rate was much higher than that of CA-GBS. Virulence genes pavA, cfb were found in all isolates. Strong correlations exist between serotype Ib (CA and HA) and surface protein genes spb1 and bac, serotype III (HA) and surface protein gene cps and GBS pilus cluster. The serotype, epidemic clone, PFGE-based genotype, and virulence gene are closely related between CA-GBS and HA-GBS, and certain serotypes and clone types were significantly associated with antibiotic resistance. However, CA-GBS and HA-GBS still had significant differences in their distribution of clone types, antibiotic resistance, and specific virulence genes, which may provide a basis for infection control.

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Section: Discussionsupporting

confidence: 59%

Molecular Characterization of Streptococcus agalactiae Causing Community- and Hospital-Acquired Infections in Shanghai, China

Jiang

Chen

et al. 2016

Front. Microbiol.

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“…In the present study, the resistance rate for erythromycin, tetracycline, and clindamycin was 49.5%, 87.5%, 49.5%, respectively. The non‐susceptibility rate for erythromycin was close to the reported rate (50.7%) in the USA, and less than the rate in China (71.2%) . The non‐susceptibility rate for tetracycline was also high.…”

Section: Discussionsupporting

confidence: 90%

“…The non‐susceptibility rate for tetracycline was also high. The non‐susceptibility rate for levofloxacin was 3.1% and the rate is lower than that reported in China (37.7%) and Japan (18.4%) . The present Taipei data are consistent with a previous study by Lee and Lai in Tainan …”

Section: Discussionsupporting

confidence: 90%

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Group B streptococcus antimicrobial resistance in neonates born to group B streptococcus‐colonized mothers: Single‐center survey

Kuok

Lin

et al. 2016

J of Obstet and Gynaecol

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“…A high prevalence of fluoroquinolone-resistant S. agalactiae isolates have been found in China and South Korea [22,23]. In China, the most prevalent serotype is III, while that in South Korea is serotype Ia.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of streptococcal toxic shock-like syndrome caused by group B streptococcus in adults in Japan between 2009 and 2013

Ikebe

Chiba²,

Shima

et al. 2015

Journal of Infection and Chemotherapy

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High Prevalence of Fluoroquinolone-Resistant Group B Streptococci among Clinical Isolates in China and Predominance of Sequence Type 19 with Serotype III

Cited by 37 publications

References 27 publications

Molecular Characterization of Streptococcus agalactiae Causing Community- and Hospital-Acquired Infections in Shanghai, China

Molecular Characterization of Streptococcus agalactiae Causing Community- and Hospital-Acquired Infections in Shanghai, China

Group B streptococcus antimicrobial resistance in neonates born to group B streptococcus‐colonized mothers: Single‐center survey

Evaluation of streptococcal toxic shock-like syndrome caused by group B streptococcus in adults in Japan between 2009 and 2013

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