High Prevalence of Frailty and Prefrailty Status in Brazilian Patients Living with HIV

Montaño-Castellón, Iris; Zeballos, Diana; Gutiérrez-Peredo, Gabriel Brayan; Netto, Eduardo Martins; Brites, Carlos

doi:10.1089/aid.2020.0113

Cited by 8 publications

(4 citation statements)

References 38 publications

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“…Fallers were older than nonfallers (P ¼ 0.003), and were more likely have prefrailty/frailty (P < 0.001) [80]. A UK-based HIV frailty clinic reported 52.5% of attendees (n ¼ 33) had fallen at least once in the previous 6 months with 26.7% reporting a fracture [74]. In a study of women living with HIV those who repeatedly fell within a 1 year time frame were likely to be frail (P ¼ 0.018) or prefrail (P ¼ 0.042), whilst the FFP nor its components were associated with short-term odds of a single fall [81].…”

Section: Fallsmentioning

confidence: 99%

“…The prevalence of frailty amongst people living with HIV remains unclear though a recent systematic review of people over 50 years living with HIV (26 studies, 6584 cases) using the FFP reported a pooled prevalence of 10.9% for frailty and 47.2% for prefrailty comparable with 11% and 42% of community-dwelling older adults without HIV, though heterogeneity between studies was high making comparison challenging [19 ▪ ]. Further studies have been conducted since using various frailty diagnostic tools with the results summarized below (Table 1) [20–24,25 ▪▪ ,26,27 ▪ ,28–30,31 ▪▪ ].…”

Section: Prevalencementioning

confidence: 99%

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Frailty in people living with HIV: an update

Jones

Levett

Barber

2021

Current Opinion in Infectious Diseases

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Purpose of reviewThe HIV population is ageing with rising rates of frailty though strategies of how best to manage it remain ill-defined. It also remains unclear what the prevalence of frailty is within this cohort, how best to diagnose it and what factors are associated. Recent findingsThe prevalence of frailty remains unclear because of heterogenous results. Routine screening in those 50þ is recommended and whilst the Fried Frailty Phenotype is currently preferred the Clinical Frailty Scale could be considered. No biomarkers are currently recommended. Looking at associated factors, HIV neurocognitive impairment and long-term alcohol usage has been shown to be associated with developing frailty whilst those who are frail have been shown to be less active and more likely to fall. NAFLD with fibrosis has been shown to be an indicator of metabolic age and the Pooled Cohort Equations has been shown to be more effective in diagnosing cardiovascular risk in frail people living with HIV.

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Section: Fallsmentioning

confidence: 99%

Section: Prevalencementioning

confidence: 99%

Frailty in people living with HIV: an update

Jones

Levett

Barber

2021

Current Opinion in Infectious Diseases

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“…Its presence is an important predictor of comorbidities and mortality among PLHIV [3,4]. Most of the available evidence on the prevalence of frailty/prefrailty in PLHIV originates from high-income countries [5,6], although some relevant studies on frailty in PLHIV have also been conducted in Brazil [7][8][9]. A recent systematic review of studies in PLHIV aged ≥50 years revealed a pooled prevalence of 10.9% for frailty and 47.2% for prefrailty [6], underscoring the critical role that these conditions play in this specific and growing population.…”

Section: Introductionmentioning

confidence: 99%

Frailty in people 50 years or older living with HIV: A sex perspective

Wiechmann,

Tejo,

Inácio

et al. 2023

HIV Medicine

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ObjectiveTo estimate prefrailty and frailty prevalence and associated factors in people living with HIV (PLHIV) from a sex perspective.MethodsCross‐sectional study on PLHIV at specialized public health centres in Brazil. Data were obtained from individuals aged ≥50 years using antiretroviral therapy (ART) and with an undetectable viral load through personal interviews, clinical evaluations and medical records. Frailty and prefrailty were characterized using the Fried Frailty Phenotype tool. Multinomial regression models were performed, and the associated factors were selected through the backward stepwise method.ResultsAmong 670 patients, 373 men and 297 women were included. The prevalence of frailty and prefrailty was significantly higher for women (16.2% and 56.2%, respectively) than for men (11.5% and 46.4%, respectively). Low socioeconomic and educational level, multimorbidity, depression, subjective cognitive complaints, and low scores on the Mini‐Mental State Exam (MMSE) were associated (P < 0.05) with frailty for both sexes. However, in the sex‐specific analysis, while smoking (OR = 3.66, 95% CI: 1.58–8.48) and a history of low adherence to ART (OR = 3.10, 95% CI: 1.33–7.23) were associated with frailty in men, depression (OR = 3.39, 95% CI: 1.36– 8.44) and the absence of functional dentition (OR = 3.77, 95% CI: 1.36– 10.43) were associated with frailty in women.ConclusionsThis study adds self‐reported cognitive complaints as a potential predictor of frailty in both sexes and supports the known deleterious effect of multimorbidity on frailty in adults living with HIV. Furthermore, it suggests that other possible predictors, such as depression, oral health status and adherence to ART, may be sex‐specific.

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“…Those experiencing frailty will likely also experience a variety of chronic illnesses such as arthritis, diabetes and Parkinson's disease (Rahman, 2018). Besides older people, frailty has been described in homeless people (Rogans‐Watson et al, 2020), middle‐aged adults (Petermann‐Rocha et al, 2021) and younger people with HIV (Montaño‐Castellón et al, 2021). While not unique to the ‘very old’ or even the old, its incidence and prevalence increase with age, as people accumulate more deficits that can render them susceptible to frailty (Rockwood & Mitnitski, 2007).…”

Section: Introductionmentioning

confidence: 99%

Frailty as biographical disruption

Cluley

Martin

Radnor

et al. 2021

Sociology Health & Illness

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Biographical disruption positions the onset of chronic illness as a major life disruption in which changes to body, self and resources occur (Sociology of Health & Illness, 4, 1982, 167–182). The concept has been used widely in medical sociology. It has also been subject to critique and development by numerous scholars. In this paper, we build on recent developments of the concept, particularly those taking a phenomenological approach, to argue that it can also help in understanding other disruptive health‐related experiences across the life course, in this case the onset of frailty. We draw on the findings of 30 situated interviews with frail older people, relating their experiences of frailty to the concept of biographical disruption. We show that frailty shares many similarities with the experience of chronic illness. Using the lens of biographical disruption to understand frailty also offers insights relevant to recent debates around both concepts, and on the continued relevance of the idea of biographical disruption given changing experiences of health and illness, including the circumstances in which biographical disruption is more and less likely to be experienced. Finally, we reflect on the potentials and limitations of applying the concept to a health‐related condition that cannot be categorised as a disease.

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High Prevalence of Frailty and Prefrailty Status in Brazilian Patients Living with HIV

Cited by 8 publications

References 38 publications

Frailty in people living with HIV: an update

Frailty in people living with HIV: an update

Frailty in people 50 years or older living with HIV: A sex perspective

Frailty as biographical disruption

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