High prevalence of genotype 6 hepatitis C virus infection in Southern Taiwan using Abbott genotype assays

Chen, Jyh-Jou; Tung, Hung‐Da; Lee, Pei‐Lun; Kuo, Hsing‐Tao; Sheu, Ming‐Jen; Cheng, Chun-Ta; Chuang, Tang‐Wei; Kao, Hsu-Ju; Lu, Na-Mi; Wu, Li-Ching; Lee, Chuan

doi:10.1016/j.jfma.2019.07.021

Cited by 17 publications

(23 citation statements)

References 33 publications

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“…The prevalence rate of genotype 1b is greater in older population (7). In recent years, genotype 6 has been more prevalent in the general Taiwanese population (8). In our study, the odds of HCV infection declined as age increased in both CRC and control groups.…”

Section: Discussionsupporting

confidence: 46%

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Section: Discussionsupporting

confidence: 46%

“…The genotype 1b HCV was more prevalent in older age groups, whereas the genotype 2a was more prevalent in younger people (7). A recent study in a southern Taiwan hospital found 18.3% of serum samples tested were genotype 6 among 1,147 patients with hepatitis C viremia (8).…”

Section: Introductionmentioning

confidence: 96%

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“…The prevalence rate of genotype 1b is greater in older population ( 7 ). In recent years, genotype 6 has been more prevalent in the general Taiwanese population ( 8 ). In our study, the odds of HCV infection declined as age increased in both CRC and control groups.…”

Section: Discussionmentioning

confidence: 99%

“…The genotype 1b HCV was more prevalent in older age groups, whereas the genotype 2a was more prevalent in younger people ( 7 ). A recent study in a southern Taiwan hospital found 18.3% of serum samples tested were genotype 6 among 1,147 patients with hepatitis C viremia ( 8 ).…”

Section: Introductionmentioning

confidence: 99%

Patients With Chronic Hepatitis C Virus Infection Are at an Increased Risk of Colorectal Cancer: A Nationwide Population-Based Case-Control Study in Taiwan

Bai

et al. 2021

Front. Oncol.

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AimStudies evaluating colorectal cancer (CRC) risk associated with chronic hepatitis C virus (HCV) infection are limited.MethodsIn this case-control study, we identify 67,670 CRC cases newly diagnosed from 2005 to 2011 and randomly selected 67,670 controls without HCV and CRC from the same database, frequency matched by age and sex of cases.ResultsResults of logistic regression analysis revealed that the adjusted odds ratio (aOR) of CRC was 1.16 (95% confidence interval [CI] = 1.08–1.24, p < 0.001) in association with chronic HCV. The CRC risk was slightly greater for women than for men. The risk decreased with age, with the aOR decreased from 2.26 (95% CI = 1.32–3.87, p = 0.003) in patients under 45 years old to 1.31 (95% CI = 1.10–1.55, p = 0.03) in patients aged 50–59, and 1.10 (95% CI = 1.00–1.22, p = 0.061) in patients aged over 70.ConclusionsOur findings suggested that patients with chronic HCV infection are at an elevated risk of developing CRC. Our data also imply that the CRC prevention programs are needed to target younger HCV patients.

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“…10,11 We recently reported unexpected high prevalence rates (17.1~18.3%) of GT 6 in Tainan City with characteristic geographic restriction between two rivers. 12,13 To clarify the epidemiology of this unique HCV genotype in southern Taiwan as a local endemic disease and its geographic variation, we further determined the GT 6 subtypes and analyzed their distribution in Tainan City.…”

Section: Introductionmentioning

confidence: 99%

Geographic Variation of Indigenous Hepatitis C Virus Subtypes 6g and 6w in an Endemic Area of Southern Taiwan

Tung¹,

P²,

Chen³

et al. 2021

Preprint

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Background and Aims: Hepatitis C virus (HCV) genotype (GT) 6 is the most genetically diverse GT and mainly distributed in Southeast Asia and south China but not Taiwan. Earlier studies showed the major GTs in Taiwan were GT 1b and GT 2 with very rare GT6 except in injection drug user and subtype 6a is the main GT 6 subtype among IDUs. Recently we reported a much higher prevalence (18.3%) of GT 6 in Tainan City, southern Taiwan. This study was designed to clarify the subtypes of GT 6 in this endemic area. Materials and Methods: A total 3022 (1343 men and 1679 women) HCV patients were enrolled. GT 6 subtypes were determined by sequencing of core/E1 and nonstructural protein 5B (NS5B) in 322 of 518 GT 6 patients. Results: The overall GT6 prevalence rate was 17.1% (518/3022) with higher prevalence districts located in northern Tainan. The major GT6 subtypes in Tainan were 6g (81.0%), followed by 6w (10.8%), 6a (7.5%), and 6n (0.7%).Conclusions: The high GT 6 prevalence in Tainan was mainly due to subtype 6g and 6w with characteristic geographic distribution, suggesting subtypes 6g and 6w could be indigenous in Tainan for centuries.

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High prevalence of genotype 6 hepatitis C virus infection in Southern Taiwan using Abbott genotype assays

Cited by 17 publications

References 33 publications

DataSheet_1.doc

DataSheet_1.doc

Patients With Chronic Hepatitis C Virus Infection Are at an Increased Risk of Colorectal Cancer: A Nationwide Population-Based Case-Control Study in Taiwan

Geographic Variation of Indigenous Hepatitis C Virus Subtypes 6g and 6w in an Endemic Area of Southern Taiwan

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