High prevalence of Hashimoto’s thyroiditis in patients with polycystic ovary syndrome: does the imbalance between estradiol and progesterone play a role?

Arduç, Ayşe; Doğan, Berçem Ayçıçek; Bilmez, Sevgi; Nasiroglu, Narin; Tuna, Mazhar Müslüm; Işık, Serhat; Berker, Dilek; Güler, Serdar

doi:10.3109/07435800.2015.1015730

Cited by 56 publications

(61 citation statements)

References 39 publications

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“…Autoimmune thyroiditis is three times more common in patients with PCOS among women of reproductive age [16]. Statistically significant increases have been shown in TPOAb and TgAb positivity in PCOS cases [17][18][19]. In our study, TPOAb and TgAb levels were higher than in the control group.…”

Section: Discussioncontrasting

confidence: 41%

Polycystic ovary syndrome and Hashimoto's thyroiditis: An autoimmune relationship

Önmez¹,

Gökosmanoğlu²,

Aksoy³

2019

Journal of Surgery and Medicine

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Aim: Polycystic ovary syndrome (PCOS) and Hashimoto's thyroiditis (HT) are common and frequently comorbid diseases. A genetic predisposition and an inflammatory and autoimmune relationship have been posited between them. This study examines the role played by autoimmunity in the relation between PCOS and HT. Methods: This case-control study was conducted at the Medical Park Hospital endocrinology and gynecology departments, Ordu, Turkey, from July 2015 to December 2018. Reproductive-age women diagnosed with PCOS based on the Rotterdam criteria, women diagnosed with HT, and healthy women with neither PCOS nor HT were included in the study. Thyroid function tests, thyroid autoantibodies, gonadotropins, androgen hormones, fasting glucose and insulin levels, and body mass index (BMI) were compared among the three groups. All patients also underwent pelvic and thyroid ultrasound examinations. Results: Five hundred ninety-six women were included in the study, 254 in the PCOS group, 190 in the HT group, and 152 in the control group. BMI was significantly higher in the PCOS and HT groups than in the control group (P=0.012, and P=0.027, respectively). Menstrual and androgenic symptoms were also significantly higher in the patient groups than in the control group (P<0.001). The incidence of TPOAb and TgAb positivity was again significantly higher in the PCOS patients than in the controls (P<0.001). Conclusion: This research demonstrated a higher prevalence of HT, together with elevated TSH, anti-TPO, and anti-Tg levels in PCOS patients. Our data suggest that thyroid functions and ovaries should be screened later in life in patients with PCOS and HT.

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Section: Discussioncontrasting

confidence: 41%

Polycystic ovary syndrome and Hashimoto's thyroiditis: An autoimmune relationship

Önmez¹,

Gökosmanoğlu²,

Aksoy³

2019

Journal of Surgery and Medicine

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“…The prevalence of thyroid autoimmunity has been found to be consistently increased in polycystic ovary syndrome (PCOS) that could lead to increase testosterone levels in women. It is suspected that PCOS and autoimmune thyroid disease may have a pathogenic link since they share similar factors, such as genetic susceptibility and sub inflammation/autoimmunity to the development of the disease [22]. In addition, we found higher levels of SHBG and low levels of progesterone in anti-TPO positive men, while reduced levels of parathyroid hormone and elevated levels of progesterone in women and men with anti-Tg positivity respectively.…”

Section: Discussionmentioning

confidence: 57%

Human Reproductive Health in Relation to Thyroid Alterations

Siriwardhane¹,

Krishna²,

Song³

et al. 2019

Health

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Background: Thyroid alterations have adverse effects on other health systems in the body, and reproductive system is one of the most affected organs. Here, we perform a comprehensive analysis on the effects of different thyroid abnormalities on sexual and reproductive-related hormones in both men and women in different age groups. Method: A comprehensive analysis was performed on 15,043 subjects within the reproductive age (15-49 years). They were tested for thyroid markers (TSH, FT4, anti-TPO, anti-Tg) and 13 reproductive hormones in Vibrant America Clinical Laboratory between March 2016 to July 2018. The alterations of each reproductive hormone in hypothyroidism, hyperthyroidism, anti-TPO+ anti-Tg+ groups were evaluated. Results: A total of 10,626 women was tested. Women with hypothyroidism had elevated cortisol and low SHBG and DHEA-S. Women with hyperthyroidism showed elevated total testosterone and SHBG. Women seropositive for anti-TPO had elevated total testosterone and low cortisol. Women seropositive for anti-Tg had low parathyroid hormones. Similarly, a total of 4417 men was tested. Men with hypothyroidism had low IGF-I. Similarly, men with hyperthyroidism had low DHEA-S, but elevated estradiol, FSH, LH and prolactin. Men seropositive for anti-TPO had elevated SHBG and low progesterone. Men seropositive for anti-Tg had elevated progesterone. The reproductive and related hormone levels of age group 36-49 showed the most variations. Conclusion: Our results clearly show that individuals with different thyroid alterations have different effects on reproductive health, especially in the age group 36-49. Hence, routine testing and follow-up checkups on reproductive system would be beneficial for individuals in the age group 36-49 with thyroid disorders.

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“…Çalışmada en sık eşlik eden hastalık PCOS (n=5) idi. Son zamanlarda yapılan çalışmalarda PCOS'lu hastalarda HT sıklığının artmış olduğu gösterilmiştir (34,35). Polikistik over sendromlu hastaların HT açısından izlenmesi gerekmektedir.…”

Section: Discussionunclassified

314

Kara¹

2020

atfm

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The aim of this study was to evaluate the clinical and laboratory findings of children and adolescents with Hashimoto thyroiditis (HT) at diagnosis and during follow-up. Materials and Methods: Between January 2015 and January 2019, a total of 181 patients aged between 4 and 18 years who were followed in the pediatric endocrinology department were evaluated. All patients were evaluated at the time of diagnosis and during follow-up with the clinical, laboratory and radiological data. Results: Female patients constituted 85% of all patients. Mean age at diagnosis was 13.4±3.2 years and 77% of patients were pubertal. The followup period was 22.5±10.3 months (4-54 months). At the time of diagnosis 35% of patients were euthyroid, 29% had subclinical hypothyroidism, 22% had overt hypothyroidism, 4% had subclinical hyperthyroidism and 10% had overt hyperthyroidism. The common complaints of the patients were fatigue (44%), hair loss (25%), constipation (23%) and goitre (21%). In the ultrasonographic imaging of the patients, nodule was detected in 13% of the patients. The frequency of nodules was higher in patients with euthyroidism. Increased size of the thyroid gland was common in patients with hyperthyroidism. In follow-up, nodule development was observed in 6% of patients. All patients with subclinical hyperthyroidism became euthyroid during follow-up. Hypothyroidism developed in 13% of euthyroid patients during follow-up. The most common concomitant diseases were polycystic ovary syndrome and vitiligo.

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High prevalence of Hashimoto’s thyroiditis in patients with polycystic ovary syndrome: does the imbalance between estradiol and progesterone play a role?

Abstract: This study demonstrated a higher prevalence of HT, elevated TSH, anti-TPO, and anti-Tg levels in PCOS patients. Increased estrogen and estrogen/progesterone ratio seem to be directly involved in high anti-TPO levels in PCOS patients.

Cited by 56 publications

References 39 publications

Polycystic ovary syndrome and Hashimoto's thyroiditis: An autoimmune relationship

Polycystic ovary syndrome and Hashimoto's thyroiditis: An autoimmune relationship

Human Reproductive Health in Relation to Thyroid Alterations

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