High Prevalence of Helicobacter heilmannii-associated Gastritis in a Small, Predominantly Rural Area: Further Evidence in Support of a Zoonosis?

Švec, Alexandr; Kordas, Panagiotis; Pavlis, Z; Novotný, J

doi:10.1080/003655200750022968

Cited by 37 publications

(3 citation statements)

References 20 publications

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“…Chronic gastritis was the most common histologic finding in our cohort, employing a well-validated gastritis scoring tool (i.e., the Updated Sydney system), consistent with previous reports. 9,22,23,[35][36][37][38][39] Compared to H. pylori, H. heilmannii-associated chronic gastritis is considered to be more focal, milder, and restricted to the antrum. 40 In our study, we also found H. heilmanniiassociated chronic gastritis to have a milder degree of inflammation compared with H. pylori.…”

Section: Discussionmentioning

confidence: 99%

Clinical presentation and outcomes of Helicobacter heilmannii gastritis in children in the New England region of the United States

Chang,

Gluchowski,

Abu Alfa

et al. 2023

J. pediatr. gastroenterol. nutr.

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ObjectiveTo describe the clinical, endoscopic, histologic, and treatment outcomes of Helicobacter heilmannii (H. heilmannii) associated gastritis in children in the New England region of the United States.MethodsRetrospective study of children (1–18 years) with H. heilmannii identified on gastric mucosal biopsies from two pediatric centers over a 21‐year period, January 2000–December 2021. Cases were identified by querying pathology databases at each institution. Demographic and clinical data were obtained from the medical record. Endoscopic and histologic findings were extracted from endoscopy and pathology reports, respectively.ResultsThirty‐eight children were diagnosed with H. heilmannii‐associated gastritis during the study period. The mean age at diagnosis was 10.1 ± 5.3 years, and 25/38 (66%) cases were male. Abdominal pain (32%) and nausea with or without vomiting (26%) were the most common symptoms. Thirty‐two children (84%) had endoscopic findings including gastric nodularity (55%) and erythema (26%). All children had histologic signs of chronic gastritis, including those with normal endoscopic exams. Antibiotic regimens used for treating Helicobacter pylori were frequently prescribed. Of the 17 children who underwent a follow‐up endoscopy (range 2–68 months), 15 (88%) did not have H. heilmannii identified on gastric biopsies.ConclusionH. heilmannii was an infrequent but potential cause of epigastric abdominal pain and nausea in our cohort of New England children. While morphologically distinct from H. pylori, the bacteria can result in similar endoscopic and histologic findings of nodularity and chronic gastritis, respectively. The rate of eradication, as assessed by histology following treatment with H. pylori therapies, was below the 90% recommended goal for antimicrobial therapies.

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Section: Discussionmentioning

confidence: 99%

Clinical presentation and outcomes of Helicobacter heilmannii gastritis in children in the New England region of the United States

Chang,

Gluchowski,

Abu Alfa

et al. 2023

J. pediatr. gastroenterol. nutr.

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“…The exact route of NHPH transmission from animals to humans is not yet clears [ 3 ]. Several studies showed that living in close proximity to as well as intense contact with infected dogs, cats, and pigs leads to a significant risk of NHPH infection [ 33 , 34 ]. Helicobacter DNA has been detected in saliva and faeces from cats and dogs [ 35 ], indicating that oral-oral and oral-faecal contact may be a route of transmission.…”

Section: Discussionmentioning

confidence: 99%

Helicobacter bizzozeronii infection in a girl with severe gastric disorders in México: case report

Montijo-Barrios,

Celestino-Pérez,

Morelia-Mandujano

et al. 2023

BMC Pediatr

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Background Gastric non-Helicobacter pylori helicobacters (NHPH) naturally colonize the stomach of animals. In humans, infection with these bacteria is associated with chronic active gastritis, peptic ulceration and MALT-lymphoma. H. bizzozeronii belongs to these NHPH and its prevalence in children is unknown. Case presentation This case report describes for the first time a NHPH infection in a 20-month-old girl with severe gastric disorders in Mexico. The patient suffered from melena, epigastric pain, and bloating. Gastroscopy showed presence of a Hiatus Hill grade I, a hemorrhagic gastropathy in the fundus and gastric body, and a Forrest class III ulcer in the fundus. Histopathologic examination revealed a chronic active gastritis with presence of long, spiral-shaped bacilli in the glandular lumen. Biopsies from antrum, body and incisure were negative for presence of H. pylori by culture and PCR, while all biopsies were positive for presence of H. bizzozeronii by PCR. Most likely, infection occurred through intense contact with the family dog. The patient received a triple therapy consisting of a proton pump inhibitor, clarithromycin, and amoxicillin for 14 days, completed with sucralfate for 6 weeks, resulting in the disappearance of her complaints. Conclusion The eradication could not be confirmed, although it was suggested by clear improvement of symptoms. This case report further emphasizes the zoonotic importance of NHPH. It can be advised to routinely check for presence of both H. pylori and NHPH in human patients with gastric complains.

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“…Alhoewel het niet exact bekend is hoe gastrale NHPH overgedragen worden van dieren naar mensen, gebeurt dit allicht vooral door direct contact. Verschillende epidemiologische studies hebben inderdaad aangetoond dat mensen die in nauw contact leven met honden, katten en vooral varkens meer kans hebben om besmet te raken met deze spiraalvormige bacteriën (Holck et al, 1997;Meining et al, 1998;Svec et al, 2000). Recentelijk werd aangetoond dat helicobacters meer dan 4 dagen kunnen overleven in water.…”

Section: Zijn Dieren Een Bron Van Infectie Met Gastrale Niet-h Pylori...unclassified

Bacteriën van huisdieren als oorzaak van maagklachten bij de mens

Haesebrouck¹,

Pasmans²,

Flahou³

et al. 2009

Vlaams Diergeneeskundig Tijdschrift

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Helicobacter pylori de belangrijkste bacterie is die geassocieerd wordt met maagklachten bij de mens, kunnen ook andere helicobacters gastritis, maagzweren en maagkanker veroorzaken bij mensen. Het gaat hier om grote, spiraalvormige bacteriën die bijzonder moeilijk of zelfs niet in het laboratorium kunnen gekweekt worden. Ze worden in de literatuur vaak aangeduid als "H. heilmannii". Deze benaming is evenwel onjuist en in feite betreft het hier minstens vijf verschillende Helicobacter species die ook voorkomen in de maag van huisdieren. H. suis is de meest frequent voorkomende gastrale niet-H. pylori Helicobacter species (NHPH) bij de mens. Deze kiem speelt ook een rol bij het ontstaan van maagulcera bij varkens. Andere NHPH die aangetroffen worden in de maag van mensen zijn H. felis, H. salomonis, H. bizzozeronii en Candidatus H. heilmannii. Deze helicobacters kunnen voorkomen in de maag van honden en katten. Candidatus H. bovis komt frequent voor in de lebmaag van runderen, maar wordt slechts uitzonderlijk gevonden bij mensen. Er zijn duidelijke aanwijzingen dat dieren een bron zijn van maaginfecties met NHPH bij de mens. Alhoewel het niet exact bekend is hoe gastrale NHPH overgedragen worden van dieren naar mensen, gebeurt dit allicht vooral door direct contact. Recentelijk is men erin geslaagd meerdere van deze kiemen in het laboratorium te isoleren uit de maag van huisdieren. Dit zal ongetwijfeld leiden tot betere inzichten in de interacties van deze kiemen met hun gastheer.

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High Prevalence of Helicobacter heilmannii-associated Gastritis in a Small, Predominantly Rural Area: Further Evidence in Support of a Zoonosis?

Cited by 37 publications

References 20 publications

Clinical presentation and outcomes of Helicobacter heilmannii gastritis in children in the New England region of the United States

Clinical presentation and outcomes of Helicobacter heilmannii gastritis in children in the New England region of the United States

Helicobacter bizzozeronii infection in a girl with severe gastric disorders in México: case report

Bacteriën van huisdieren als oorzaak van maagklachten bij de mens

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