High prevalence of Helicobacter pylori infection in Behcet’s disease

Lankarani, Kamran Bagheri; Ravanbod, Mohammad Reza; Aflaki, Elham; Nazarinia, Mohammad Ali; Rajaee, A

doi:10.1186/1471-230x-14-58

Cited by 14 publications

(9 citation statements)

References 23 publications

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“…BD also frequently involves other organs such as the vascular system, musculoskeletal system, gastrointestinal (GI) tract and central nervous system (CNS). The etiology and pathogenesis of BD is not completely understood but it may be an inflammatory reaction triggered by microbial agents [1][2][3][4][5][6][7][8][9] in a genetically susceptible host. [10][11][12][13][14][15][16][17][18][19] In addition to microbial agents, other environmental factors such as vitamin D deficiency [20][21][22][23][24] are also important.…”

Section: Introductionmentioning

confidence: 99%

Demographic and clinical features of Behcet's disease in Azerbaijan

et al. 2014

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Section: Introductionmentioning

confidence: 99%

Demographic and clinical features of Behcet's disease in Azerbaijan

et al. 2014

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“…This research identified 91 related references, of which 6 papers met our inclusion criteria . The flowchart that described the process of study selection is shown in Figure .…”

Section: Resultsmentioning

confidence: 99%

“…This research identified 91 related references, of which 6 papers met our inclusion criteria. [13][14][15][16][17][18] The flowchart that described the process of study selection is shown in Figure 1. There were 1119 participants including 449 patients with BS and 670 healthy controls.…”

Section: Basic Characteristicsmentioning

confidence: 99%

Is Helicobacter pylori associated with Behçet's syndrome? A meta‐analysis

Yao

Liang

et al. 2019

Helicobacter

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Background Preceding studies have reported the relationship between Helicobacter pylori (H pylori) and Behçet's syndrome (BS), but there still exists controversy. In this study, we firstly conducted a meta‐analysis to clarify the relationship of these two diseases. Methods Articles published until July 1, 2019, in the PubMed, MEDLINE, and Embase databases with restriction of English‐language studies were searched and reviewed. According to the inclusion criteria, relevant statistical data were extracted and analyzed. Results Six articles were finally included. The result showed that BS individuals were 1.39 times more susceptible to H pylori infection (OR = 1.39, 95% CI = (1.03, 1.87)). In addition, it found that oral ulceration (OR = 27.98, 95% CI = (3.49, 224.49)), genital ulceration (OR = 3.15, 95% CI = (1.51, 6.56)), and cutaneous lesions (OR = 4.29, 95% CI = (2.14, 8.61)) were alleviated after H pylori eradication. Publication bias and sensitivity analysis showed no statistical heterogeneity. Conclusions BS patients had higher rate of H pylori infection, and clinical symptoms including oral ulceration, genital ulceration, and cutaneous lesions can be improved after H pylori eradication. The results indicated that H pylori may be an etiological factor to BS.

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“…It has been reported that active H pylori infection, as diagnosed with UBT, was 3.1 times more prevalent among patients with BD than in controls. 88 Moreover, in a small cohort of patients with BD, a significant improvement in the number and size of oral and genital ulcers was observed after H pylori eradication. 89 These findings were confirmed in a recent meta-analysis, reporting that BD patients were more susceptible to H pylori infection, with an OR of 1.39 (95% CI, 1.03-1.87).…”

Section: Autoimmune Diseasesmentioning

confidence: 97%

Review: Extragastric diseases andHelicobacter pylori

et al. 2020

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The involvement of Helicobacter pylori infection in many extra‐gastroduodenal manifestations remains a fascinating field of investigation. However, for several of these supposed associations, the potential pathogenic mechanism remains unclear. The present review highlights the main associations of H pylori with extra‐gastroduodenal manifestations reported during the last year. We searched for the most relevant studies on this topic, published between April 2019 and March 2020, identified using the term “Helicobacter” in the MEDLINE/Pubmed database. Consistent data emerged from studies investigating metabolic syndrome and ischaemic cardiovascular diseases. Other reported fields of investigation were hepatology, especially focused on non‐alcoholic steatohepatitis, neurology, including Parkinson’s disease and Alzheimer’s disease, as well as dermatology. Inflammatory bowel disease (IBD), that comprises Crohn’s disease and ulcerative colitis, may originate from a dysregulation of the host’s immune response to commensal bacteria in individuals with genetic predisposition. The reduction of biodiversity and other specific imbalances in the faecal microbiome composition of IBD patients compared to that of healthy controls support this hypothesis. In this context, an inverse correlation between H pylori infection and IBD prevalence has been confirmed. Similar results were found in patients with kidney diseases and allergic manifestations. There are indications of the possible involvement of H pylori infection in metabolic syndrome and ischaemic cardiovascular diseases. However, due to a series of factors linked to study designs and the multifactorial pathogenesis of some diseases, further studies are needed.

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High prevalence of Helicobacter pylori infection in Behcet’s disease

Cited by 14 publications

References 23 publications

Demographic and clinical features of Behcet's disease in Azerbaijan

Demographic and clinical features of Behcet's disease in Azerbaijan

Is Helicobacter pylori associated with Behçet's syndrome? A meta‐analysis

Review: Extragastric diseases andHelicobacter pylori

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