High prevalence of hepatitis C virus infection in patients with B‐cell lymphoproliferative disorders in Italy

Rosa, Gennaro De; Gobbo, Maria Luisa; Renzo, Amalia De; Notaro, Rosario; Garofalo, Salvatore; Grimaldi, Maria; Apuzzo, Aurora; Chiurazzi, Federico; Picardi, Marco; Matarazzo, Margherita; Rotoli, Bruno

doi:10.1002/(sici)1096-8652(199706)55:2<77::aid-ajh5>3.0.co;2-#

Cited by 89 publications

(86 citation statements)

References 30 publications

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“…In contrast, serum from a WM patient with known chronic HCV infection tested positive in both assay systems. Our findings, therefore do not demonstrate an association between HCV infection and WM, in contrast to the findings in smaller studies of WM patients by other investigators [3,4,6] . While these studies would argue against chronic HCV infection as a potential variable in the pathogenesis of WM, other sources of chronic antigen stimulation (including from other pathogens and drugs) may exist.…”

Section: Resultscontrasting

confidence: 99%

“…In previous studies, an association between hepatitis C virus (HCV) infection and WM has been suggested. Using enzyme-linked immunosorbent (ELISA) and polymerase chain reaction (PCR)-based assays for HCV detection, DeRosa et al [3] reported that 8/13 (61.5%) WM patients were positive for HCV. The prevalence of HCV among 400 patients with various B-cell malignancies was studied by Mele et al [4] in an Italian multicenter case-control study using primarily an ELISA-based assay to determine HCV infection; this study demonstrated an overall HCV infection rate of 17.5%.…”

Section: Introductionmentioning

confidence: 99%

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Hepatitis C viral infection is not associated with Waldenström's macroglobulinemia

Leleu

O’Connor

et al. 2006

American J Hematol

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While a familial predisposition may exist in up to 20% of patients with Waldenströ m's Macroglobulinemia (WM), the precipitating cause of this B-cell malignancy remains unknown in most patients. In previous studies, an association between hepatitis C virus (HCV) infection and WM has been suggested as etiological. This relationship has been the subject of debate, however, with some studies demonstrating increased incidence of HCV infection among WM patients and other studies showing no such association exists. This discordance might be attributable to the analytical method used, HCV antibody detection, which might be ineffective in patients with immunosuppression. We therefore analyzed the prevalence of HCV in a large population of WM patients utilizing both an HCV antibody detection immunoassay as well as qualitative polymerase chain reaction assay to directly detect HCV presence in serum samples. None of 100 randomly tested WM patients in this study tested positive for HCV by either analytical method. Our results therefore demonstrate a lack of association between HCV and WM. Am. J. Hematol. 82:83-84, 2007. V V C 2006 Wiley-Liss, Inc.

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Section: Resultscontrasting

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Hepatitis C viral infection is not associated with Waldenström's macroglobulinemia

Leleu

O’Connor

et al. 2006

American J Hematol

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“…However, Hodgkin's lymphoma and T-cell non-Hodgkin's lymphomas do not have a HCV prevalence rate significantly different from that of the general population. 40 In contrast to the reported studies of systemic B-cell non-Hodgkin's lymphomas from Italy, 8,10 the subtypes of PLL in HCV positive patients were not different from PLL in HCV negative patients, with a predominance of high-grade lymphomas. Our data confirm the high prevalence of HCV in nonHodgkin's lymphomas with detectable levels of cryoglobulins.…”

Section: Discussionmentioning

confidence: 81%

Primary Lymphoma of the Liver: Clinical–Pathological Features and Relationship With Hcv Infection in French Patients

et al. 2003

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Primary lymphoma of the liver (PLL) is rare. In some cases, the hepatic lymphoma has been diagnosed in patients who were infected by the hepatitis C virus (HCV). It has been suggested that HCV plays a role in the pathogenesis of lymphoma. The aim of our multicentric retrospective study was to assess the characteristics of PLL and to determine the prevalence of HCV infection in PLL. Thirty-one immunocompetent patients (anti-human immunodeficiency virus, anti-human T-cell leukemia/lymphoma virus negative, no history of allograft) with PLL fulfilled the entire selection criteria. The liver biopsy specimens were reassessed by the same pathologist. The non-Hodgkin's lymphomas were classified according to the World Health Organization classification. Blood samples were tested in 28 patients for antibodies to HCV, and HCV RNA was detected by reverse transcription polymerase chain reaction. In the majority of cases, the clinical, biologic, and radiologic data were nonspecific. Twentyseven of 31 patients presented a B-cell lymphoma corresponding to the centroblastic morphologic variant of a diffuse, large B-cell lymphoma (22 cases), a Burkitt's lymphoma (1 case), an extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue type (3 cases), and unclassified, small B-cell lymphoma (1 case). The 4 other cases were T-cell lymphomas. The prevalence of HCV infection was 21% (6 of 28 cases). All of these patients were positive for HCV RNA by polymerase chain reaction in blood. Most of the HCVinfected patients presented a high-grade, B-cell type lymphoma. In conclusion, our study confirms the rarity of PLL and demonstrates an increased prevalence of HCV infection. H epatitis C virus (HCV) is a hepatotropic virus;however, the HCV genome and its replicative intermediate have been detected in peripheral blood mononuclear cells in patients with chronic HCV infection. 1,2 There is a strong association between HCV and type II mixed cryoglobulinemia. [3][4][5] Antibodies to HCV and HCV RNA have been found in up to 98% of patients with mixed cryoglobulinemia, 3 and approximately 36% of patients with chronic HCV infection have mixed cryoglobulinemia. 5 Mixed cryoglobulinemia is considered by some investigators to be a variant of lowgrade, B-cell non-Hodgkin's lymphoma. 6,7 This has prompted several groups to investigate the association between HCV infection and overt B-cell malignancies. Evidence suggesting a direct relationship between HCV infection and development of these tumors have been reported in several Italian studies and in one American study, which demonstrates a high prevalence of chronic HCV infection, 9% to 42%, in patients with B-cell lymphoma. [8][9][10][11] However, data from other countries have not confirmed these findings. [12][13][14][15] Primary lymphoma of the liver (PLL) is rare, with less than 150 cases reported. 16,17 In some cases, the hepatic lymphoma was diagnosed in From the

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“…The prevalence of anti-HCV and/or HCV-RNA positivity has been reported as between 42 and 100% (Agnello et al, 1992;Santini et al, 1993;Ferri et al, 1993;Cacoub et al, 1994;Pozzato et al, 1994;Mussini et al, 1995). In eight studies from Italy, 25% of the patients (range 9-40%) with B-cell NHL were positive for HCV antibodies (Ferri et al, 1994;Cavanna et al, 1995;Mazzuro et al, 1996;Pioltelli et al, 1996;Silvestri et al, 1996;Usto et al, 1996;Luppi et al, 1997;de Rosa et al, 1997). In these studies, HCV positivity was much higher than in agecomparable groups of the Italian population.…”

Section: Discussionmentioning

confidence: 95%

Prevalence of hepatitis C virus infection in patients with lymphoproliferative disorders in Southern Turkey

et al. 1999

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Anti-hepatitis C virus (HCV) antibody prevalence was investigated in 228 patients with lymphoproliferative disorders (LPDs). Twenty-six of 228 (11.40%) patients with LPDs were positive for anti-HCV which was higher than the donor population ( P = 0.0007). Nine of 98 cases with non-Hodgkin's lymphoma, five of 47 cases with multiple myeloma, seven of 36 cases with Hodgkin's disease, four of 38 cases with chronic lymphocytic leukaemia and one of nine cases with acute lymphoblastic leukaemia had anti-HCV antibody. In all patients, odds ratio (OR) for anti-HCV was 24.09. This value was higher in patients less than 35 years as 62.04 for below 25 years and 32.00 for between 25–35 years. Our findings suggest that HCV infection might be a causative and/or contributing factor in lymphoproliferation. © 1999 Cancer Research Campaign

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High prevalence of hepatitis C virus infection in patients with B‐cell lymphoproliferative disorders in Italy

Cited by 89 publications

References 30 publications

Hepatitis C viral infection is not associated with Waldenström's macroglobulinemia

Hepatitis C viral infection is not associated with Waldenström's macroglobulinemia

Primary Lymphoma of the Liver: Clinical–Pathological Features and Relationship With Hcv Infection in French Patients

Prevalence of hepatitis C virus infection in patients with lymphoproliferative disorders in Southern Turkey

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