High prevalence of hla‐cw1 and cw2 antigens in spondylarthritis

Kozin, Franklin; Duquesnoy, René J.; Rodey, Glenn E.; Lightfoot, Robert W.; Ryan, Lawrence M.

doi:10.1002/art.1780210804

Cited by 12 publications

(4 citation statements)

References 23 publications

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“…These antigens were usually present in B27-positive patients, which is natural because of their strong allelic association. Excess of Cwl and Cw2 has been observed previously in patients with ankylosing spondylitis and Reiter's disease (43,(45)(46)(47).…”

Section: Discussionsupporting

confidence: 52%

Followup study on patients with reiter's disease and reactive arthritis, with special reference to HLA—B27

Leirisalo

Skylv

Kousa

et al. 1982

Arthritis & Rheumatism

212

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An analysis of 160 patients with Reiter's disease, 144 with yersinia arthritis, and 9 with salmonella arthritis was performed. Complete or incomplete Reiter's syndrome was observed in one‐third of the patients with yersinia arthritis and in most of those with salmonella arthritis. During the followup period, chronic back pain and joint symptoms were frequent in all the patient groups. Patients who were HLA—B27 positive had a more severe acute disease (more frequent back pain, urologic symptoms, mucocutaneous manifestations, and a longer duration of the disease) and more frequent chronic back pain and sacroiliitis.

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Section: Discussionsupporting

confidence: 52%

Followup study on patients with reiter's disease and reactive arthritis, with special reference to HLA—B27

Leirisalo

Skylv

Kousa

et al. 1982

Arthritis & Rheumatism

212

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“…A high prevalence of HLA-Cw1 antigens has been described in spondylarthritis since 1978, [55][56][57][58] and in patients with the spondylitis type of psoriatic arthritis [59]. The HLA-Cw1 allele was increased in Spanish patients with psoriatic arthritis, especially the axial type, although this association may be secondary to the linkage between HLA-B27.5 and HLA-Cw1 [60].…”

Section: Hla-cw1 and Psoriatic Arthritismentioning

confidence: 99%

HLA-Cw1 and Psoriasis

Huang

Tsai

2021

Am J Clin Dermatol

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Psoriasis is a chronic inflammatory skin condition with regional and ethnic differences in its prevalence and clinical manifestations. Human leukocyte antigen (HLA)-Cw6 is the disease allele conferring the greatest risk to psoriasis, but its prevalence is lower in Asian individuals. Recent studies have found associations between HLA-Cw1 and some Asian populations with psoriasis, especially Southern Chinese. HLA-Cw6 was associated with type I early-onset psoriasis, guttate psoriasis, Koebner phenomenon, and better response to methotrexate, interleukin (IL)-12/23, IL-17, and IL-23 targeting drugs. In contrast, HLA-Cw1 positivity has been associated with erythrodermic psoriasis, pustular psoriasis, and the axial type of psoriatic arthritis. Furthermore, HLA-Cw1 was more frequently associated with high-need patients who did not respond to conventional therapies. No known trigger factor nor autoantigen has been identified for HLA-Cw1 positivity. However, HLA-Cw1 has been linked to some viral agents. For example, cytotoxic T lymphocytes recognize multiple cytomegalovirus pp65-derived epitopes presented by HLA alleles, including HLA-C*01:02. In addition, cytomegalovirus can lead to severe exacerbation of psoriatic skin disease. The proposed interaction between viral infection, HLA-Cw1, and psoriasis is through the killer cell immunoglobulin-like receptors of natural killer cells. Given the diverse nature of psoriasis pathogenesis and the difference in HLA-Cw prevalence in different racial groups, more studies are needed to confirm the role of HLA-Cw1 in psoriasis. Key PointsHuman leukocyte antigen (HLA)-Cw1 is a less recognized but important HLA-Cw allele associated with psoriasis in some Asian ethnicities.Patients carrying HLA-Cw1 tend to show higher disease activity, have an increased risk of developing erythrodermic psoriasis, and are more refractory to treatments.

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“…The high prevalence of HLA Cw2 could be anticipated from previous reports (Kozin et al 1978, Arnett et al 1978.…”

Section: Discussionmentioning

confidence: 59%

HLA antigens, psoriasis and acute anterior uveitis in Bechterew's syndrome (ankylosing spondylitis)

1982

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One hundred and twenty‐two consecutively hospitalized patients with ankylosing spondylitis (AS) were reexamined. Ninety‐two per cent were HLA B27 positive. Of the HLA B27 negative patients, 60% were found to have psoriasis, as opposed to 11 % of the HLA B27 positive patients. Acute anterior uveitis (AAU) was found only in HLA B27 positive patients, and more frequently in males than in females. The genetic and clinical heterogeneity of AS, together with the overlapping clinical criteria for AS and psoriatic spondylitis, may make the term “Bechterew's syndrome” preferable. Based on these findings and previous reports, we conclude that (i) AAU is a manifestation of Bechterew's syndrome in HLA B27 positive patients, (ii) HLA B27 negative patients without any obvious accompanying manifestations may suffer from psoriatic spondylitis, and (iii) genetic predisposition to psoriasis in persons who are HLA B13, B17 and B37 negative, may interact with the genetic predisposition to Bechterew's syndrome in HLA B27 positive persons and produce Bechterew's syndrome with psoriasis or psoriasis‐like skin eruptions.

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High prevalence of hla‐cw1 and cw2 antigens in spondylarthritis

Cited by 12 publications

References 23 publications

Followup study on patients with reiter's disease and reactive arthritis, with special reference to HLA—B27

Followup study on patients with reiter's disease and reactive arthritis, with special reference to HLA—B27

HLA-Cw1 and Psoriasis

HLA antigens, psoriasis and acute anterior uveitis in Bechterew's syndrome (ankylosing spondylitis)

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