High prevalence of hpv multiple genotypes in women with persistent chlamydia trachomatis infection

Seraceni, Silva; Seta, Francesco De; Colli, Claudia; Savio, Rossella Del; Pesel, Giuliano; Zanin, Valentina; D’Agaro, Pierlanfranco; Contini, Carlo; Comar, Manola

doi:10.1186/1750-9378-9-30

Cited by 30 publications

(27 citation statements)

References 38 publications

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“…In a recent publication, Seraceni et al. used molecular techniques to distinguish between recently acquired and chronic chlamydia infections in a cross-sectional study design 23 . They reported a significantly higher frequency of HPV co-infection, as well as a significantly higher number of HPV types, in chronic carriers of C. trachomatis .…”

Section: Discussionmentioning

confidence: 99%

Incidence and persistence of carcinogenic genital human papillomavirus infections in young women with or without Chlamydia trachomatis co‐infection

et al. 2015

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We assessed whether infection with chlamydia increases the incidence of carcinogenic human papillomavirus (HPV) infections and if HPV persistence is affected by chlamydia co-infection. For 1982 women (16–29 years-old) participating in two consecutive rounds of a chlamydia screening implementation trial, swabs were polymerase chain reaction tested to detect chlamydia and 14 carcinogenic HPV genotypes. HPV type-specific incidence and persistence rates were stratified for chlamydia positivity at follow-up. Associations were assessed by multilevel logistic regression analyses with correction for sexual risk factors. HPV type-specific incidence ranged from 1.4% to 8.9% and persistence from 22.7% to 59.4% after a median follow-up of 11 months (interquartile range: 11–12). Differences in 1-year HPV persistence rates between chlamydia -infected and noninfected women were less distinct than differences in HPV incidence rates (pooled adjusted odds ratios of 1.17 [95% CI: 0.69–1.96] and 1.84 [95% CI: 1.36–2.47], respectively). The effect of chlamydia co-infection on HPV-infection risk did not significantly differ by HPV genotype. In conclusion, infection with chlamydia increases the risk of infection by carcinogenic HPV types and may enhance persistence of some HPV types. Although these findings could reflect residual confounding through unobserved risk factors, our results do give reason to explore more fully the association between chlamydia and HPV type-specific acquisition and persistence.

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Section: Discussionmentioning

confidence: 99%

Incidence and persistence of carcinogenic genital human papillomavirus infections in young women with or without Chlamydia trachomatis co‐infection

et al. 2015

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“…The evaluation of C. trachomatis Hsp60 gene (Ct604) expression was performed to define the chronic status of infection by a RT‐PCR ( q PCR) protocol as previously described …”

Section: Methodsmentioning

confidence: 99%

Chlamydia trachomatis and HPV co‐infections in HIV negative men from a multi‐ethnic area of Northern Italy at high prevalence of cervical malignancies

Comar

Monasta

Seraceni

et al. 2017

Journal of Medical Virology

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Chlamydia trachomatis and HPV coinfections in the male population are often a disregarded issue. We performed a study to evaluate the prevalence of such infections in heterosexual HIV negative men from a Northern Italy multi-ethnic area at high prevalence for cervical malignancies. Urethral swabs (US) or first-voided urine were evaluated retrospectively from 1317 patients attending Sexually Transmitted Infections (STI) clinic and from 3388 outpatients attending private clinics. Informations about participants' demographic characteristics and attributes of C. trachomatis, including chronic infection, and HPV genotypes testing, were collected. Exact Fisher test, bivariate, and multivariate logistic regressions were carried out. The prevalence of C. trachomatis was 1.7% in the outpatients and 16.9% in the STI group (P < 0.0001) in which the highest frequency was observed in men of age ≤25 years. Among patients with C. trachomatis, asymptomatic HPV co-infection was detected in 33% of men from the STI clinic and in 2% of the outpatients. Out of all coinfections, 56% were due to single HPV, with a prevalence of 73% in young STI men. The distribution of HPV genotypes confirmed the increased circulation of LR-HPV42, HR-HPV51, HR-HPV52 and prHR-HPV82, and the decreasing of HR-HPV16. African nationalities and leucorrhea were significantly associated risk factors, while the regular condom use offered an effective protection. This study highlights the high prevalence of C. trachomatis and HPV asymptomatic co-infection in young HIV negative men attending the STI clinic, representing a reservoir of new HPV genotypes with potential oncogenic risk.

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“…Quantitative real-time PCR was performed to assess the transcriptional level of the Hsp60 gene (Ct604), as described previously (Contini & Seraceni, 2012;Seraceni et al, 2014). To avoid falsepositive results, a serial standard curve, a negative control with PCR-grade water and a positive control (C. trachomatis strain TW-3) were included in the assay.…”

Section: Methodsmentioning

confidence: 99%

“…Chronic C. trachomatis infection characterized the majority of the co-infections (Seraceni et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

HPV genotypes distribution in Chlamydia trachomatis co-infection in a large cohort of women from north-east Italy

Seraceni

Campisciano

Contini

et al. 2016

Journal of Medical Microbiology

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Human papillomavirus (HPV) and Chlamydia trachomatis are pathogens with oncogenic potential associated with persistent infections. Epidemiological data on C. trachomatis infection status, C. trachomatis/HPV co-infection and the relationship between HPV genotypes in Italian women are only preliminary. The aim of the present study was to characterize the relationship between HPV genotypes and C. trachomatis in an extending cohort of asymptomatic immunocompetent women from an area of north-east Italy. A retrospective study was conducted using Luminex technology on cervical swabs from asymptomatic immunocompetent women, comprising 921 attending the prevention centre for the Cervical Cancer Program and 6214 who had been referred to the Sexually Transmitted Infections Center, with clinical indications of HPV and C. trachomatis infections. A quantitative real-time PCR was performed to assess chronic C. trachomatis infection by heat-shock protein 60 (Hsp60) gene expression. The overall prevalence of the investigated pathogens was 39 % (359/921) for HPV and 4 % (251/6214) for C. trachomatis. The Hsp60 gene was detected in 57 % of the women infected with C. trachomatis. HPV co-infection was present in 58 % of C. trachomatis-infected women. A high prevalence of co-infection was found in women with chronic C. trachomatis infection (68 %, P50.0002), especially in women j25 years (72 %) where HPV multiple infections were found in 78 % (P50.022). HPV genotype distribution showed that uncommon low-risk genotypes were associated with C. trachomatis. These results indicate a high frequency of co-detection of multiple HPV genotypes in chronically infected young women and suggest that the expression of the C. trachomatis Hsp60 gene may favour HPV infection.

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High prevalence of hpv multiple genotypes in women with persistent chlamydia trachomatis infection

Cited by 30 publications

References 38 publications

Incidence and persistence of carcinogenic genital human papillomavirus infections in young women with or without Chlamydia trachomatis co‐infection

Incidence and persistence of carcinogenic genital human papillomavirus infections in young women with or without Chlamydia trachomatis co‐infection

Chlamydia trachomatis and HPV co‐infections in HIV negative men from a multi‐ethnic area of Northern Italy at high prevalence of cervical malignancies

HPV genotypes distribution in Chlamydia trachomatis co-infection in a large cohort of women from north-east Italy

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