High prevalence of Human Herpesvirus 8 in schizophrenic patients

Hannachi, N.; Kissi, Y. El; Samoud, S.; Nakhli, Jaâfar; Letaief, Leila; Gaabout, S.; Ali, B. Ben Hadj; Boukadida, Jalel

doi:10.1016/j.psychres.2013.12.035

Cited by 10 publications

(5 citation statements)

References 39 publications

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“…The seroprevalence rate of HHV-8 infection among healthy blood donors was relatively lower (7.1%) than with previous studies in Tunisia reporting (13-15%) in blood donors 13 , 19 , 13% in pregnant women, and 12% in children 13 , which suggests that Tunisia is classified into the intermediate prevalence region, although large geographic variation seems to exist within the Mediterranean regions 20 . In this study, none of the healthy blood donors showed evidence of HHV-8 DNAemia.…”

Section: Discussioncontrasting

confidence: 71%

Human herpesvirus-8 infection in Tunisian adult acute leukemia patients

Handous¹,

Hannachi²,

Achour³

et al. 2023

Afr H. Sci.

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Background: Human herpesvirus 8 (HHV-8) has been linked to the development of Kaposi's sarcoma (KS)and multiple other hematologic malignant disorders. However, the role of HHV-8 in acute leukemia patients is unknown. Objectives: The objective of this study was to determine the prevalence of HHV-8 in Tunisian acute leukemia patients and in healthy blood donors. Methods: An indirect immunofluorescence test was used to detect the presence of anti-HHV8 antibodies. Nested PCR was used for the detection of HHV-8 DNAemia in samples of plasma. Results: The seroprevalence of HHV-8 was significantly higher in acute leukemia patients (21,4% ,15/70) than in healthy blood donors (7,1%, 5/70), (p= 0.02). Gender, type of disease, status of disease, prior blood transfusion, and outcome were not associated with HHV-8 seroprevalence. However, among acute leukemia patients, HHV-8 seroprevalence was statistically associated with older age > 40 years of age, (p=0.002). HHV-8 DNAemia was detected (1,4%) in only one patient of acute myeloid leukemia (AML) and none of the healthy blood donors. Conclusions: The seroprevalence of HHV-8 infection in Tunisian adult acute leukemia patients was three times as high compared to healthy blood donors, suggesting that patients with acute leukemia might be at increased risk of HHV-8 infection. Keywords: Human herpesvirus 8; acute leukemia patients; blood donors; prevalence.

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Section: Discussioncontrasting

confidence: 71%

Human herpesvirus-8 infection in Tunisian adult acute leukemia patients

Handous¹,

Hannachi²,

Achour³

et al. 2023

Afr H. Sci.

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“…The results showed that most of the DEmRNAs involve in viral infection and three different signaling pathways. A previous study found a higher prevalence of human herpesvirus 8 (HHV8) infection in the patients with SCZ against the control group 70 . HHV8 has been associated with the development of Kaposi sarcoma 71 .…”

Section: Discussionmentioning

confidence: 94%

Bioinformatics analysis of long non-coding RNA-associated competing endogenous RNA network in schizophrenia

Sabaie

Moghaddam

et al. 2021

Sci Rep

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Schizophrenia (SCZ) is a serious psychiatric condition with a 1% lifetime risk. SCZ is one of the top ten global causes of disabilities. Despite numerous attempts to understand the function of genetic factors in SCZ development, genetic components in SCZ pathophysiology remain unknown. The competing endogenous RNA (ceRNA) network has been demonstrated to be involved in the development of many kinds of diseases. The ceRNA hypothesis states that cross-talks between coding and non-coding RNAs, including long non-coding RNAs (lncRNAs), via miRNA complementary sequences known as miRNA response elements, creates a large regulatory network across the transcriptome. In the present study, we developed a lncRNA-related ceRNA network to elucidate molecular regulatory mechanisms involved in SCZ. Microarray datasets associated with brain regions (GSE53987) and lymphoblasts (LBs) derived from peripheral blood (sample set B from GSE73129) of SCZ patients and control subjects containing information about both mRNAs and lncRNAs were downloaded from the Gene Expression Omnibus database. The GSE53987 comprised 48 brain samples taken from SCZ patients (15 HPC: hippocampus, 15 BA46: Brodmann area 46, 18 STR: striatum) and 55 brain samples taken from control subjects (18 HPC, 19 BA46, 18 STR). The sample set B of GSE73129 comprised 30 LB samples (15 patients with SCZ and 15 controls). Differentially expressed mRNAs (DEmRNAs) and lncRNAs (DElncRNAs) were identified using the limma package of the R software. Using DIANA-LncBase, Human MicroRNA Disease Database (HMDD), and miRTarBase, the lncRNA- associated ceRNA network was generated. Pathway enrichment of DEmRNAs was performed using the Enrichr tool. We developed a protein–protein interaction network of DEmRNAs and identified the top five hub genes by the use of STRING and Cytoscape, respectively. Eventually, the hub genes, DElncRNAs, and predictive miRNAs were chosen to reconstruct the subceRNA networks. Our bioinformatics analysis showed that twelve key DEmRNAs, including BDNF, VEGFA, FGF2, FOS, CD44, SOX2, NRAS, SPARC, ZFP36, FGG, ELAVL1, and STARD13, participate in the ceRNA network in SCZ. We also identified DLX6-AS1, NEAT1, MINCR, LINC01094, DLGAP1-AS1, BABAM2-AS1, PAX8-AS1, ZFHX4-AS1, XIST, and MALAT1 as key DElncRNAs regulating the genes mentioned above. Furthermore, expression of 15 DEmRNAs (e.g., ADM and HLA-DRB1) and one DElncRNA (XIST) were changed in both the brain and LB, suggesting that they could be regarded as candidates for future biomarker studies. The study indicated that ceRNAs could be research candidates for investigating SCZ molecular pathways.

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“… 77 , 85 , 92 Whereas 74.10% (95% CI 53.20–87.89%) had had sexual relationships with another person at least once in their lifetime, 37 , 49 , 53 , 77 , 79 , 81 , 93 only 37.72% (95% CI 31.52–44.35%) were sexually active (defined in most cases as sexual intercourse at least once over the previous 12 months). 50 , 53 , 77 , 79 , 84 , 85 , 92 , 94 , 98 Among those who were sexually active, 35.37% (95% CI 15.56–61.92%) reported having multiple partners, 50 , 53 , 83 , 84 , 87 , 96 30.95% (95% CI 11.88–59.84%) had paid for sexual relationships, 50 , 53 , 92 and 13.38% (95% CI 5.02–31.09%) reported having had relationships in exchange for goods or money. 50 , 83 , 87 Only 34.98% (95% CI 16.58–59.29%) reported consistent use of a condom in their relationships, 37 , 49 , 53 , 80 , 83 , 96 whereas 55.28% (95% CI 24.59–82.41%) reported having unprotected sexual relationships, 49 , 50 , 80 , 87 , 98 , 99 and 28.72% (95% CI 8.38–63.99%) of patients had experienced an unplanned pregnancy on the part of themselves or their partners 49 , 50 , 92 , 100 , 101 ( Table 3A and Supplementary Fig.…”

Section: Resultsmentioning

confidence: 99%

“…When compared with healthy controls, patients with schizophrenia were significantly less likely to be in a stable relationship ( k = 6, odds ratio = 0.18, 95% CI 0.07–0.45, P < 0.01) 49 , 50 , 78 , 79 , 84 , 89 or to be sexually active ( k = 4, odds ratio 0.19, 95% CI 0.13–0.29, P < 0.01) 50 , 79 , 84 , 92 ( Tables 2B and 3B , and Supplementary Fig. 2(h, j)).…”

Section: Resultsmentioning

confidence: 99%

Sexually transmitted infections, sexual life and risk behaviours of people living with schizophrenia: systematic review and meta-analysis

Aymerich,

Pedruzo,

Salazar de Pablo

et al. 2024

BJPsych open

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Background Sexually transmitted infections (STIs), along with sexual health and behaviour, have received little attention in schizophrenia patients. Aims To systematically review and meta-analytically characterise the prevalence of STIs and sexual risk behaviours among schizophrenia patients. Method Web of Science, PubMed, BIOSIS, KCI-Korean Journal Database, MEDLINE, Russian Science Citation Index, SciELO and Cochrane Central Register were systematically searched from inception to 6 July 2023. Studies reporting on the prevalence or odds ratio of any STI or any outcome related to sexual risk behaviours among schizophrenia samples were included. PRISMA/MOOSE-compliant (CRD42023443602) random-effects meta-analyses were used for the selected outcomes. Q-statistics, I2 index, sensitivity analyses and meta-regressions were used. Study quality and publication bias were assessed. Results Forty-eight studies (N = 2 459 456) reporting on STI prevalence (including 15 allowing for calculation of an odds ratio) and 33 studies (N = 4255) reporting on sexual risk behaviours were included. Schizophrenia samples showed a high prevalence of STIs and higher risks of HIV (odds ratio = 2.11; 95% CI 1.23–3.63), hepatitis C virus (HCV, odds ratio = 4.54; 95% CI 2.15–961) and hepatitis B virus (HBV; odds ratio = 2.42; 95% CI 1.95–3.01) infections than healthy controls. HIV prevalence was higher in Africa compared with other continents and in in-patient (rather than out-patient) settings. Finally, 37.7% (95% CI 31.5–44.4%) of patients were sexually active; 35.0% (95% CI 6.6–59.3%) reported consistent condom use, and 55.3% (95% CI 25.0–82.4%) maintained unprotected sexual relationships. Conclusions Schizophrenia patients have high prevalence of STIs, with several-fold increased risks of HIV, HBV and HCV infection compared with the general population. Sexual health must be considered as an integral component of care.

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High prevalence of Human Herpesvirus 8 in schizophrenic patients

Cited by 10 publications

References 39 publications

Human herpesvirus-8 infection in Tunisian adult acute leukemia patients

Human herpesvirus-8 infection in Tunisian adult acute leukemia patients

Bioinformatics analysis of long non-coding RNA-associated competing endogenous RNA network in schizophrenia

Sexually transmitted infections, sexual life and risk behaviours of people living with schizophrenia: systematic review and meta-analysis

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