High Prevalence of Human Papillomavirus (HPV) Infections and High Frequency of Multiple HPV Genotypes in Human Immunodeficiency Virus-Infected Women in Brazil

Levi, José Eduardo; Kleter, Bernhard; Quint, Wim; Fink, Maria C. S.; Canto, Cynthia L.M.; Matsubara, R.; Linhares, Iara M.; Segurado, Aluísio Cotrim; Vanderborght, Bart; Eluf-Neto, José; Doorn, Leen–Jan van

doi:10.1128/jcm.40.9.3341-3345.2002

Cited by 194 publications

(191 citation statements)

References 26 publications

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“…Dois estudos brasileiros, realizados respectivamente em São Paulo e Região Sudeste, encontraram prevalência de 2,1 e 2,6% utilizando também a citologia oncótica para o diagnós-tico 16,17 , enquanto pesquisa realizada nas Regiões Sudeste e Sul e na cidade de Buenos Aires verificou prevalência mais elevada (31%), ressalta-se que foram consideradas todas as alterações citológicas -incluindo ASCUS -ou NIC na biópsia cervical 18 . Está bem documentado que as mulheres positivas para o HIV têm alta prevalência de infecção cervical pelo HPV e de NIC ou SIL (lesão intraepitelial) 19,20 . A análise da literatura mundial também destacou grandes variações.…”

Section: Métodosunclassified

Prevalência de infecção cervical por papilomavírus humano e neoplasia intraepitelial cervical em mulheres HIV-positivas e negativas

Ceccato¹,

Lopes²,

Nascimento³

et al. 2015

Rev. Bras. Ginecol. Obstet.

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Resumo OBJETIVO: Realizar estudo comparativo entre mulheres positivas e negativas para o vírus da imunodeficiência humana (HIV), analisando: prevalência de neoplasia intraepitelial cervical (NIC) e infecção cervical pelo papilomavírus humano (HPV); risco viral e relação com desenvolvimento de NIC; parâmetros sociodemográficos e de comportamento que influenciaram na presença de infecção cervical por HPV e NIC. MÉTODOS: Estudo comparativo entre mulheres positivas e negativas para o HIV, sendo analisadas, respectivamente, 202 e 171 mulheres para avaliar a prevalência de NIC e 164 e 100 mulheres para avaliar a prevalência de infecção cervical pelo HPV. Em todas as consultas foram realizados: coleta de amostras cervicais para realização de citologia oncótica e reação em cadeia da polimerase (PCR) para detecção do DNA-HPV; colposcopia; questionário padronizado para coleta de dados demográficos/comportamentais; biópsia de todas as alterações colposcópicas. O exame histopatológico foi o padrão-ouro para o diagnóstico de NIC. RESULTADOS: A prevalência de NIC foi de 2,4 e 15,3% (p<0,001) e de infecção cervical pelo HPV foi de 37,1 e 55,5% (p=0,002), respectivamente, nas negativas e positivas para o HIV. As soropositivas tiveram mais infecção por HPV de alto risco (35,7 e 23,6%; p=0,02) e por múltiplos tipos (6,2 e 0%). O HPV 16 foi o tipo prevalente, ocorrendo em 11,3 e 10,2% das positivas e negativas para o HIV e também nas mulheres que tiveram NIC nos dois grupos. Os fatores associados ao desenvolvimento de NIC foram: infecção pelo HIV (HT=4,64; IC95% 2,23-9,65), idade (HT=0,95; IC95% 0,93-0,98 para cada ano de vida) e estado civil (HT=0,49; IC95% 0,30-0,80). Os fatores associados à infecção pelo HPV foram: presença do HIV (HT=2,72; IC95% 1,77-4,17), maior número de parceiros sexuais (HT=1,87; IC95% 1,23-2,84), idade (HT=0,97; IC95% 0,95-0,99 para cada ano de vida) e estado civil (HT=0,65: IC95% 0,42-1,0 para união estável/viúvas). CONCLUSÃO: A prevalência de NIC e infecção cervical pelo HPV foi maior nas mulheres positivas para o HIV, que também apresentaram mais infecções por HPV de alto risco e múltiplos tipos. O tipo 16 foi o predominante nos dois grupos e nas mulheres que tiveram NIC. As mulheres com mais idade e união estável/viúvas tiveram menor chance de adquirir infecção cervical por HPV e NIC. AbstractPURPOSE: To conduct a comparative study between two groups of women (HIV positive and negative) analyzing: the prevalence of cervical intraepithelial neoplasia (CIN) and cervical HPV infection; viral risk and relationship with development of CIN; and sociodemographic and behavioral parameters that influence cervical HPV infection and the development of CIN. METHODS: A cross-sectional study in which 202 HIV-positive women and 164 HIV-negative women were analyzed to assess the prevalence of CIN and 171 HIV-positive women and 160 HIV-negative women were analyzed to assess the prevalence of cervical HPV infection. The following procedures were performed on the occasion of each medical visit: collection of cervical sa...

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Section: Métodosunclassified

Prevalência de infecção cervical por papilomavírus humano e neoplasia intraepitelial cervical em mulheres HIV-positivas e negativas

Ceccato¹,

Lopes²,

Nascimento³

et al. 2015

Rev. Bras. Ginecol. Obstet.

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“…The HPV types 16 and 18 are the most frequent types found in cervical squamous cell carcinoma, accounting for more than 70% of cases 18 . A higher frequency of HPV infection and an increased risk of cervical cancer are found in immunosuppressed women, as can be observed in human immunodeficiency virus (HIV)-infected patients [19][20][21] . The studies that assessed the association of HPV infection in HTLV-1 patients have not reached a consensus on the epidemiological aspects of this co-infection [22][23][24][25] .…”

Section: Introductionmentioning

confidence: 85%

“…These immunological abnormalities and the highest exposure to risk factors common to HTLV-1 and HPV could explain the high prevalence of HPV infection 31 . Other immunosuppressive diseases are also associated with a high prevalence of HPV infection, such as HIV infection 20 and systemic lupus erythematosus 32 . However, no difference was found in the proportion of CD4-T lymphocytes and in the HTLV-1 proviral load of HTLV-1-infected patients with HPV, compared with HTLV-1-infected women.…”

Section: Discussionmentioning

confidence: 99%

“…infection among HTLV-infected and uninfected groups when women were stratified into age ranges (15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35), 36-45, 46-55, and 56-65 years). Four positive cases of HPV infection (18.2%) were observed in HTLV-infected women with 46-55 years, whereas none was found in the control group at same age (p = 0.31) (data not shown).…”

Section: Ethical Considerationsmentioning

confidence: 99%

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Evidence of a higher prevalence of HPV infection in HTLV-1-infected women: a cross-sectional study

Lôpo

Oliveira

Santana

et al. 2012

Rev. Soc. Bras. Med. Trop.

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INTRODUCTION:HTLV-1 infection increases susceptibility to other infections. Few studies have addressed the co-infection between HPV and HTLV-1 and the immune response involved in this interaction. The aim of this study was to determine the prevalence of cervical HPV infection in HTLV-1-infected women and to establish the risk factors involved in this co-infection. METHODS: A cross-sectional study was carried out in Salvador, Brazil, between September 2005 and December 2008, involving 50 HTLV-1-infected women from the HTLV Reference Center and 40 uninfected patients from gynecological clinic, both at the Bahiana School of Medicine. HPV infection was assessed using hybrid capture. HTLV-1 proviral load was quantified using real-time polymerase chain reaction (PCR). RESULTS: The mean age of HTLV-1-infected women (38 ± 10 years) was similar to that of the control group (36 ± 13 years). The prevalence of HPV infection was 44% in the HTLV-1-infected group and 22.5% in uninfected women (p = 0.03). HTLV-1-infected women had lower mean age at onset of sexual life (17 ± 3 years versus 19 ± 3 years; p = 0.03) and greater number of lifetime partners compared with the control group (4 ± 3 versus 2 ± 1; p < 0.01). In the group of HTLV-1-infected patients, there was neither difference in HTLV-1 proviral load between HPV-infected women and the uninfected. CONCLUSIONS: The prevalence of HPV infection was higher in HTLV-1-infected women. Further studies should be performed to evaluate the progression of this co-infection.

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“…The most important types are classified in the mucosa HPV group and present a high prevalence worldwide, such as HPV 16, 18, 31, 33, 35, 45, 51 and 58. In this way, HIV infected women tend to acquire high risk HPV types in single or in multiple infections (Levi et al 2002). Among high risk types linked to squamous intraepithelial lesions (SIL), HPV 16 is the most common type in HIV seronegative people, and it is associated with the majority of high grade lesions and carcinoma.…”

Section: Introductionmentioning

confidence: 99%

Human Papillomavirus Infection in Human Immunodeficiency Virus Positive Women Under Routine Pap Smear

Oliveira¹,

Haimuri²,

Jacyntho³

et al. 2008

VR&R

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The present study aimed to investigate HPV prevalence associated with cervical cytology and to evaluate data from 140 HIV positive women routinely attended at an outpatient public gynecological service in Rio de Janeiro state. The CD4 cell counts and HIV-1 RNA levels were determined using standardized protocols. HPV status and HPV 16 detection were ascertained respectively by My09/11 consensus primers and type specific primers. Colpocytology was performed at the first or subsequent visit to the service.

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High Prevalence of Human Papillomavirus (HPV) Infections and High Frequency of Multiple HPV Genotypes in Human Immunodeficiency Virus-Infected Women in Brazil

Abstract: A group of 208 human immunodeficiency virus (HIV)-infected women in

Cited by 194 publications

References 26 publications

Prevalência de infecção cervical por papilomavírus humano e neoplasia intraepitelial cervical em mulheres HIV-positivas e negativas

Prevalência de infecção cervical por papilomavírus humano e neoplasia intraepitelial cervical em mulheres HIV-positivas e negativas

Evidence of a higher prevalence of HPV infection in HTLV-1-infected women: a cross-sectional study

Human Papillomavirus Infection in Human Immunodeficiency Virus Positive Women Under Routine Pap Smear

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