High prevalence of hyperhomocysteinemia in chronic alcoholism: the importance of the thermolabile form of the enzyme methylenetetrahydrofolate reductase (MTHFR)

Vega, María José; Santolaria, Francisco; González‐Reimers, Emilio; Alemán, Marı́a Remedios; Milena, Antonio; Martı́nez-Riera, Antonio; González-Garcı́a, Cándido

doi:10.1016/s0741-8329(01)00167-7

Cited by 51 publications

(20 citation statements)

References 46 publications

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“…The interaction between smoking and MTHFR polymorphism in increased risk of pancreatic cancer could be explained by two possible mechanisms: (a) Smokers may tend to have lower intake of dietary folate and lower levels of serum or tissue folate (58) and smoking is also known to interfere with the metabolism of (62), and hepatocellular carcinoma (22). Although heavy users of alcohol may tend to have a diet low in fruits and vegetables, which may lead to a suboptimal level of serum folate, alcohol itself is known to decrease folate absorption, alter its metabolism, increase its excretion, and therefore deplete 5-methyl THF (63)(64)(65)(66). In this study population, light alcohol consumption (V86 ethanol/wk, median value of control drinkers) showed a protective effect on the risk of pancreatic cancer, whereas heavy alcohol consumption did not show any significant effect on the risk of pancreatic cancer.…”

Section: Discussionmentioning

confidence: 99%

5,10-Methylenetetrahydrofolate Reductase Polymorphisms and the Risk of Pancreatic Cancer

Li¹,

Ahmed²,

Li³

et al. 2005

Cancer Epidemiology, Biomarkers &Amp; Prevention

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To test the hypothesis that 5,10-methylenetetrahydrofolate reductase (MTHFR) polymorphisms modify the risk of pancreatic cancer, we conducted a hospital-based, casecontrol study involving 347 patients with newly diagnosed pancreatic adenocarcinoma and 348 healthy controls, frequency matched by age, sex, and race. MTHFR polymorphisms were determined using the PCR-RFLP method. Association of these polymorphisms with the risk of pancreatic cancer was estimated by unconditional logistic regression analysis. We found that the C667T (but not the A1298C) polymorphism had a significant main effect on the risk of pancreatic cancer. The frequencies of the MTHFR 667CC, 667CT, and 667TT genotypes were 49.5%, 38.6%, and 11.9%, respectively, among cases compared with 48.5%, 45.0%, and 6.5%, respectively, among controls. Individuals with the 667TT genotype displayed a 2-fold increased risk for pancreatic cancer compared with those with the CC/CT genotypes [adjusted odds ratio (OR), 2.14; 95% confidence interval (95% CI), 1.14-4.01]. Multivariate analyses found that the effect of the 677TT genotype on the risk of pancreatic cancer was present among ever smokers (OR, 5.53; 95% CI, 2.0-15.3) and ever alcohol drinkers (OR, 3.16; 95% CI, 1.30-7.69) but not in never smokers (OR, 0.82; 95% CI, 0.33-2.06) and never drinkers (OR, 1.42; 95% CI, 0.56-3.62). Furthermore, a positive interaction between the MTHFR TT genotype and heavy smoking or heavy alcohol consumption was detected. The OR (95% CI) of pancreatic cancer was 6.83 (1.91-24.38) for heavy smokers among the TT carriers compared with never smokers with the CC/CT genotypes and 4. 23 (0.88-20.3) for heavy drinkers with the TT genotype compared with nondrinkers with the CC/CT genotypes. These observations support a role for folate metabolism in pancreatic cancer, especially among smokers and heavy drinkers. (Cancer Epidemiol Biomarkers Prev 2005;14(6):1470 -6)

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Section: Discussionmentioning

confidence: 99%

5,10-Methylenetetrahydrofolate Reductase Polymorphisms and the Risk of Pancreatic Cancer

Li¹,

Ahmed²,

Li³

et al. 2005

Cancer Epidemiology, Biomarkers &Amp; Prevention

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“…Recent results on the relation of alcohol consumption and homocysteine level are conflicting (Ubbink et al, 1998;Jacques et al, 2001), although studies seem consistent in the effect of heavy alcohol drinking and increased homocysteine (Cravo et al, 1996;de la Vega et al, 2001). Homocysteine is an independent risk factor of occlusive vascular disease (McCully, 1996;Graham et al, 1997) and should be considered in an overall risk assessment of alcohol consumption in relation to cardiovascular disease.…”

Section: Introductionmentioning

confidence: 99%

Alcohol consumption and its relation to cardiovascular risk factors in Germany

Burger

Mensink

Brönstrup³

et al. 2004

Eur J Clin Nutr

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Objective: To analyse the association of alcohol consumption and blood lipids, haemostatic factors, and homocysteine in German adults by gender and age groups. Design: Cross-sectional population-based survey. Setting: Data from the German National Health Interview and Examination Survey 1998, representative for age, gender, community size, and federal state. Subjects: From a sample of 7124 Germans between 18 and 79 y old, 2420 women and 2365 men were selected. Only individuals who were not currently receiving medical treatment or did not have disorders related to cardiovascular disease were selected for this study. Results: Using analyses of variance, mean blood levels of total cholesterol, HDL cholesterol, HDL/total cholesterol ratio, total glycerides, fibrinogen, antithrombin III, and homocysteine adjusted for age, socioeconomic status, East/West Germany residence, body mass index, tobacco use, sports activity, and coffee consumption, if appropriate are presented by alcohol consumption groups (0, 40-10, 410-20, 420-30 and 430 g/day). The HDL/total cholesterol ratio increased with higher alcohol groups up to 10-20 g/day ( þ 15%) for women and 430 g/day ( þ 18%) for men, showing the strongest rise among men aged 55-79 y. Fibrinogen decreased with higher alcohol groups up to 10-20 g/day for women and 20-30 g/day for men. Among women, homocysteine levels showed a U-shaped curve with a minimum of 8.49 mmol/l at 10-20 g alcohol/day (À8%, reference: nondrinking), whereas an inverse association was observed for men. Conclusions: Moderate alcohol consumption is associated with favourable levels of several cardiovascular risk factors. The most favourable cardiovascular risk factor profile among women was observed among those drinking 10-20 g alcohol/day. Beneficial effects seem to be more pronounced among older men.

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“…Further research was conducted supporting the evidence that alcoholism and cigarette smoking seriously harm an addict's vitamin B levels [15]. Researchers suggest that one's diet and vitamin B levels, other micronutrients, and balancing serum foliate can support an alcoholic's nutritional recovery and ultimately one's health and healing process [16].…”

Section: Literature Reviewmentioning

confidence: 99%

Nutrition in Addiction Treatment

Szydlowski¹,

Amato²

2017

J Tradi Med Clin Natur

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Care planning for individuals in addiction recovery is often challenging given the complexity of the disease and the uniqueness to the individual with compounding factors impacting one's health. Often times discharge planners and case managers design a care plan based on insurance coverage and available community resources such as structured support groups. As part of this planning, the research purpose of this study is to review the need and benefits of integrating nutritional support for individual in addiction recovery to support health and ongoing sobriety. The use of food and nutrition principles in the addiction and recovery industry are limited at best. The paper includes a comprehensive review of the existing literature as it relates to the benefits and uses of vitamins, minerals, eating patterns, and other lifestyle behaviors that can influence one's ability to succeed in sustaining sobriety. Personal reflection and discussion on the existing literature is provided. Results conclude the systemic integration of nutritional support can have positive effects on addiction recovery.

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High prevalence of hyperhomocysteinemia in chronic alcoholism: the importance of the thermolabile form of the enzyme methylenetetrahydrofolate reductase (MTHFR)

Cited by 51 publications

References 46 publications

5,10-Methylenetetrahydrofolate Reductase Polymorphisms and the Risk of Pancreatic Cancer

5,10-Methylenetetrahydrofolate Reductase Polymorphisms and the Risk of Pancreatic Cancer

Alcohol consumption and its relation to cardiovascular risk factors in Germany

Nutrition in Addiction Treatment

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