High Prevalence of Insufficient Vitamin D Intake and Serum 25-Hydroxyvitamin D in Chinese School-Age Children: A Cross-Sectional Study

Liu, Yan; Zhao, Aihua; Zheng, Wei; Guo, Mofan; Xue, Yong; Wang, Peiyu; Zhang, Yumei

doi:10.3390/nu10070822

Cited by 20 publications

(15 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Yet the association of vitamin D intervention and sun exposure on healthy children are not well documented given that few guidelines support serum 25(OH) D test for children [12]. However, previous studies suggested that circulating vitamin D level should be measured even in healthy children with a risk of vitamin D deficiency mainly due to inadequate sun exposure [13,14], in order to early prevent vitamin D deficiency-related diseases.…”

Section: Introductionmentioning

confidence: 99%

Association of serum 25-Hydroxyvitamin D with Vitamin D intervention and outdoor activity among children in North China: an observational study

Zhang¹,

Chen²,

Jin

et al. 2020

BMC Pediatr

View full text Add to dashboard Cite

Background Living at high latitudes is one of the risk factors for vitamin D deficiency in children. However, evidence on vitamin D improvement for this pediatric population to date is limited. This study aims at evaluating the association of different vitamin D intervention methods and outdoor activity on the vitamin D status of children in North China. Methods In this observational study, a total of 55,925 children aged 1 month to 18 years old were recruited from pediatric outpatient departments from July 2016 to June 2017. Data on demographics, anthropometric measurements, vitamin D intervention (either prescribed by physicians or given by parents) and outdoor activity were recorded. The serum levels of 25-hydroxycholecalciferol (25(OH)D) were determined by high performance liquid chromatography tandem–mass spectrometry. Logistic regression analysis was performed to assess the association of vitamin D intervention or outdoor activity with blood vitamin D status, adjusted for age, gender, BMI for age, and seasons. Results The overall rate of hypovitaminosis D was 65.60%. Of the children’s outdoor activity, 35.63, 31.95, and 32.42% were below 30 min/d, 30–60 min/d and over 60 min/d, respectively. Furthermore, the proportion of therapeutic intervention, supplementation intervention and no vitamin D intervention among the children was 16.48, 32.87, and 50.65%, respectively. After adjusted for confounding factors, vitamin D intervention was associated with a lower risk of hypovitaminosis D, with OR (95% CI) of 0.191 (0.180, 0.202) in children with therapeutic doses and 0.423 (0.404, 0.443) in those with supplementation doses, compared with children without vitamin D intervention. In addition, longer outdoor time was associated with a lower risk of hypovitaminosis D [0.479 (0.456, 0.504) for 60 min/d, 0.737 (0.701, 0.776) for 30–60 min/d], independent of vitamin D intervention. Conclusions High prevalence of vitamin D deficiency was found in children living at high latitudes. Vitamin D intervention and outdoor activity are all negatively associated with children’s vitamin D deficiency. Routine vitamin D intervention combined with increased outdoor time might be an effective approach to prevent hypovitaminosis D among children, especially those at school, living at high latitudes.

show abstract

Section: Introductionmentioning

confidence: 99%

Association of serum 25-Hydroxyvitamin D with Vitamin D intervention and outdoor activity among children in North China: an observational study

Zhang¹,

Chen²,

Jin

et al. 2020

BMC Pediatr

View full text Add to dashboard Cite

show abstract

“…Nassar et al [41] stated that the vitamin D level was significantly lower in children with delayed school achievement, with a positive correlation between vitamin D level and Wechsler Intelligence Scale values for Children. Another cross-section study by Liu et al [32] conducted on 563 children (9.5 ± 1.6 years) from 6 areas of China, showed that serum vitamin D concentration was positively associated with the intelligence score. In the current study, cognitive function parameters of ISS children were within the average range of IQ classifications, but non-verbal IQ, full-scale IQ, fluid reasoning, knowledge, and working memory were significantly lower than those in the control group, with a positive correlation between vitamin D level and all cognitive function parameters.…”

Section: Discussionmentioning

confidence: 99%

“…The effect of vitamin D level on growth was demonstrated in different age groups, and multiple studies demonstrated that vitamin D status affects growth outcome and is associated with stunted growth in the pediatric age group [22,30,31]. Liu et al [32] revealed a positive correlation between serum 25(OH)D concentration and BMI-for-age Z score in school-aged children. Miguel [33] stated that serum levels of vitamin D varied significantly between different BMI groups with the lowest levels in individuals with either high or low BMI, demonstrating a curvilinear, U-shaped association.…”

Section: Discussionmentioning

confidence: 99%

Effect of circulating 25-hydroxyvitamin D and antioxidant capacity level on cognitive function parameters of children with idiopathic short stature

Ahmed

Sakhr

Ali

et al. 2020

Egypt Pediatric Association Gaz

View full text Add to dashboard Cite

Background: An optimal level of vitamin D is necessary for normal bone growth. Recently, vitamin D has been linked to many neurological disorders, changes in antioxidant capacity levels, and cognitive function decline in old age; thus, the aim was to evaluate the effect of vitamin D and antioxidant levels on the cognitive function parameters of children with idiopathic short stature (ISS). Results: A prospective case-control study was conducted with 60 primary school-aged children with ISS who were compared to 60 unrelated healthy age-and sex-matched children as a control group. A complete clinical evaluation; anthropometric measurements; neurocognitive function parameters using the Stanford-Binet test, fifth edition; vitamin D level; total antioxidant capacity (TAC); total oxidative stress (TOS); and oxidative stress index (OSI) were measured. A total of 83.3% of children with ISS had a vitamin D level < 30 ng/ml with significantly lower vitamin D levels than the control group. The TAC level was significantly lower in children with ISS than in healthy children. Children with ISS had an average level for all of the cognitive function parameters but a lower non-verbal IQ, full-scale IQ, fluid reasoning, knowledge, quantitative reasoning, and working memory than healthy controls. A positive correlation was found between vitamin D level and all anthropometric measurements, all IQ parameters, and TAC levels in the studied children. A positive correlation was found between TAC and all IQ parameters. Conclusion: Vitamin D level and antioxidant capacity level have a major impact on cognitive function parameters in children with ISS.

show abstract

“…Yet the effect of vitamin D intervention and sun exposure on healthy children are not well documented given that few guidelines support serum 25(OH)D test for children [12] . However, previous studies suggested that circulating vitamin D level should be measured even in healthy children with a risk of vitamin D de ciency mainly due to inadequate sun exposure [13,14] , in order to early prevent vitamin D de ciency-related diseases.…”

Section: Introductionmentioning

confidence: 99%

Effect of Vitamin D Intervention and outdoor activity on serum 25-Hydroxyvitamin D among children in North China: an observational study

Zhang

Chen

Jin

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: Living at high latitudes is one of the risk factors for vitamin D deficiency in children. However, evidence on vitamin D improvement for this pediatric population to date is limited. This study aims at evaluating the effect of different vitamin D intervention methods and outdoor activity on the vitamin D status of children in North China. Methods: A total of 55,925 children aged 1 month to 18 years old were recruited from pediatric outpatient departments from July 2016 to June 2017. Data on demographics, anthropometric measurements, vitamin D intervention, and outdoor activity were recorded. The serum levels of 25-hydroxycholecalciferol (25(OH)D) were determined by high performance liquid chromatography tandem–mass spectrometry. Logistic regression analysis was performed to assess the association of vitamin D intervention or outdoor activity with blood vitamin D status, adjusted for age, gender, BMI for age, and seasons.Results: The overall rate of hypovitaminosis D was 65.60%. Of the children’s outdoor activity, 35.63%, 31.95%, and 32.42% were below 30min/d, 30-60 min/d and over 60min/d, respectively. Furthermore, the proportion of therapeutic intervention, supplementation intervention and no vitamin D intervention among the children was 16.48%, 32.87%, and 50.65%, respectively. After adjusted for confounding factors, vitamin D intervention was associated with a lower risk of hypovitaminosis D, with OR (95% CI) of 0.191 (0.180, 0.202) in children with therapeutic doses and 0.423 (0.404, 0.443) in those with supplementation doses, compared with children without vitamin D intervention. In addition, longer outdoor time was associated with a lower risk of hypovitaminosis D [0.479 (0.456, 0.504) for 60 min/d, 0.737 (0.701, 0.776) for 30–60 min/d], independent of vitamin D intervention. Conclusions: High prevalence of vitamin D deficiency was found in children living at high latitudes. Vitamin D intervention and outdoor activity are all negatively associated with children’s vitamin D deficiency. Routine vitamin D intervention combined with increased outdoor time might be an effective approach to prevent hypovitaminosis D among children, especially those at school, living at high latitudes.

show abstract

High Prevalence of Insufficient Vitamin D Intake and Serum 25-Hydroxyvitamin D in Chinese School-Age Children: A Cross-Sectional Study

Cited by 20 publications

References 32 publications

Association of serum 25-Hydroxyvitamin D with Vitamin D intervention and outdoor activity among children in North China: an observational study

Association of serum 25-Hydroxyvitamin D with Vitamin D intervention and outdoor activity among children in North China: an observational study

Effect of circulating 25-hydroxyvitamin D and antioxidant capacity level on cognitive function parameters of children with idiopathic short stature

Effect of Vitamin D Intervention and outdoor activity on serum 25-Hydroxyvitamin D among children in North China: an observational study

Contact Info

Product

Resources

About