High Prevalence of Low Bone Mineral Density in Patients With Tropical Calcific Pancreatitis

Abstract

Despite their young age, patients with TCP have significantly low BMD. Measures to improve nutrition should be instituted in all TCP patients from an early age.

Bone mineral metabolism and bone mineral density in alcohol related and idiopathic chronic pancreatitis

“…16 In a cross-sectional study, Joshi et al studied 72 patients with tropical chronic pancreatitis (TCP) and found that their lumbar spine and total hip BMD were significantly lower than that in the controls. 10 They also found that vitamin D deficiency was equally prevalent among patients (86%) and controls (85%).However, we did not find any statistically significant correlation between chronic pancreatitis severity based on the Cambridge Criteria and the average spinal and femoral T-scores in our patients. There was also no significant difference in the number of patients with osteoporosis and osteopenia across different Cambridge groups.…”

“…[7][8][9] Moreover, majority of these studies have enrolled patients with ACP and very few studies have examined BMD in ICP patients. 4,10 All these studies have shown that BMD is reduced significantly in patients with chronic pancreatitis and these patients are at increased risk of bone fractures.Our study corroborates that nearly two-thirds of our chronic pancreatitis patients had metabolic bone disease and these patients are at increased risk of bone fractures. Dujsikova et al studied 73 patients (17 females and 56 males)…”

“…10 These TCP patients had significantly lower body mass index (BMI) and serum albumin levels than the controls, suggesting that malnutrition is an important factor contributing to abnormal bone mineral metabolism in these patients. 10 We have recently reported that the clinical profile of ICP in north India differs from the classical TCP described in literature.Our patients showed normal BMI with higher incidence of pain and lower frequencies of diabetes, calcification and intraductal calculi. 11,12 These differences in ICP profile are probably due to the change in environment,dietary habits and nutritional status which have accompanied the economic development over last two decades.Since vitamin D deficiency is not the only factor disrupting bone mineral metabolism in ICP patients, it is pertinent to examine the effect improved nutritional status has on this disease.We prospectively studied BMD, vitamin D status and bone mineralization parameters in 103 patients with chronic pancreatitis and compared them between patients with alcohol related chronic pancreatitis (ACP) and idiopathic chronic pancreatitis (ICP).…”

“…In the same context, bone mineral metabolism in patients with idiopathic chronic pancreatitis (ICP) has been inadequately studied. 10 A study from India reported a high frequency of low bone mineral density (BMD) in patients with tropical chronic pancreatitis (TCP). 10 These TCP patients had significantly lower body mass index (BMI) and serum albumin levels than the controls, suggesting that malnutrition is an important factor contributing to abnormal bone mineral metabolism in these patients.…”

“…10 A study from India reported a high frequency of low bone mineral density (BMD) in patients with tropical chronic pancreatitis (TCP). 10 These TCP patients had significantly lower body mass index (BMI) and serum albumin levels than the controls, suggesting that malnutrition is an important factor contributing to abnormal bone mineral metabolism in these patients. 10 We have recently reported that the clinical profile of ICP in north India differs from the classical TCP described in literature.Our patients showed normal BMI with higher incidence of pain and lower frequencies of diabetes, calcification and intraductal calculi.…”