High prevalence of low serum vitamin B<sub>12</sub> in a multi‐ethnic Israeli population

Gielchinsky, Yuval; Elstein, Deborah; Green, Ralph; Miller, Joshua W.; Elstein, Y.; Algur, Nurit; Lahad, Amnon; Shinar, Eilat; Abrahamov, Ayala; Zimran, Ari

doi:10.1046/j.1365-2141.2001.03156.x

Cited by 48 publications

(36 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This is similar to a previous report from north Jordan on 216 healthy individuals by Fora and Mohammad where a suboptimal (< 222 pg/mL) serum level of B 12 was observed in 48.1% of patients [14], and also similar to reports from Israel by Masalha et al (49%) and Gielchinsky et al (31%) [15,16]. Similar reports of high prevalence in this region came from Turkey (46.8%) [17] and the Islamic Republic of Iran (26.7%) [18].…”

Section: Discussionsupporting

confidence: 81%

High frequency of low serum levels of vitamin B [12] among patients attending Jordan University Hospital

Barghouti¹,

Younes²,

Halaseh³

et al. 2009

East Mediterr Health J

View full text Add to dashboard Cite

This study aimed to estimate the status of serum vitamin B 12 level in patients attending Jordan University Hospital in Amman, and to examine the relationship with demographic data, chronic illness, dietary habits, haematological parameters and symptoms related to vitamin B 12 levels. A total of 838 patients completed a questionnaire and gave blood samples; 44.6% were vitamin B 12 deficient (< 180 pg/mL) and 34.2% had hypovitaminosis (180-300 pg/mL). Vitamin B 12 deficiency was associated with memory impairment, low meat intake and strict vegetarian (vegan) diets. The high frequency of low vitamin B 12 warrants the development of a strategy to correct this problem in Jordan. Fréquence élevée de faibles taux de vitamine B 12 sériques chez les patients de l'hôpital universitaire de Jordanie RÉSUMÉ Cette étude visait à estimer les taux de vitamine B12 sériques chez les patients de l'hôpital universitaire de Jordanie à Amman, et à examiner la relation avec les données démographiques, les maladies chroniques, les habitudes alimentaires, les paramètres hématologiques et les symptômes liés à ces taux. Au total, 838 patients ont rempli un questionnaire et ont été soumis à une prise de sang ; 44,6 % présentaient une déficience en vitamine B12 (< 180 pg/mL) et 34,2 % une hypovitaminose (180-300 pg/mL). La déficience en vitamine B12 était associée à des troubles de la mémoire, de faibles apports carnés et un régime végétarien strict (végétalien). La fréquence élevée de faibles taux de vitamine B12 justifie l'élaboration d'une stratégie visant à corriger ce problème en Jordanie.

show abstract

Section: Discussionsupporting

confidence: 81%

High frequency of low serum levels of vitamin B [12] among patients attending Jordan University Hospital

Barghouti¹,

Younes²,

Halaseh³

et al. 2009

East Mediterr Health J

View full text Add to dashboard Cite

show abstract

“…The findings from several studies performed in different clinical settings have confirmed that serum vitamin B12 is a relatively poor marker with low sensitivity and specificity in predicting vitamin B12 status and that holoTC is a useful diagnostic indicator for this purpose [3,5]. In addition, a few studies performed in different countries and ethnic groups have shown differences in the prevalence of vitamin B12 deficiency and have also revealed that holoTC is a more sensitive marker than total serum vitamin B12 for investigating vitamin B12 status [5,12,[16][17][18][19]. However, most of the previous studies were performed using radioimmunoassays, and very few studies have been performed with the more recent microparticle enzyme immunoassays.…”

mentioning

confidence: 99%

Relationship between the Levels of Holotranscobalamin and Vitamin B12

et al. 2010

View full text Add to dashboard Cite

Vitamin B12 is essential for cellular metabolism, particularly DNA synthesis and regulation. Vitamin B12 deficiency may cause severe and irreversible damage, and early detection of vitamin B12 deficiency is important. While vitamin B12 status is currently determined by performing blood tests to assess serum vitamin B12 levels, the diagnostic accuracy of these tests is low [1,2].To obtain a more sensitive marker of vitamin B12 status, a new test involving measurement of the levels of holotranscobalamin (holoTC)-transcobalamin-vitamin B12 complex-has been introduced [3][4][5][6][7]. HoloTC promotes global cellular uptake of cobalamin by specific receptors; therefore, it may be more sensitive than serum vitamin B12 levels in indicating vitamin B12 status [8]. We investigated the association between the levels of holoTC and serum vitamin B12, determined the diagnostic value of holoTC levels in populations susceptible to vitamin B12 deficiency, and performed a precision test for the AxSYM holoTC assay.We included 45 samples from patients for whom a serum 185To date, the determination of serum vitamin B12 levels has been the most common laboratory test for the assessment of vitamin B12 status; however, the diagnostic accuracy of this test is low. To obtain a more sensitive marker, a new test to measure holotranscobalamin (holoTC) levels has been introduced. In this study, we assessed 45 patients for whom a vitamin B12 test had been requested and 139 anemic patients. We investigated the associations between the levels of homocysteine (Hcy) and those of holoTC, serum vitamin B12, and folate and assessed the diagnostic value of holoTC levels as a marker for vitamin B12 deficiency. We also determined the precision of the AxSYM holoTC assay by calculating the coefficient of variance (CV). The within-run and betweenrun precision values were excellent, as all CV values were less than 3.5%. The holoTC levels were low (<35 pmol/L) in 7 samples, and 6 of these samples had normal total serum vitamin B12 levels. In 2 of these samples, high Hcy levels (>12 mmol/L) indicated vitamin B12 deficiency. Thus, the holoTC levels were more sensitive than the serum vitamin B12 levels for indicating vitamin B12 status. If the serum vitamin B12 level is 151-300 pmol/L, the levels of holoTC alone or in combination with serum vitamin B12 levels are likely to be more useful markers than serum vitamin B12 levels alone. (Korean J Lab Med 2010;30:185-9)

show abstract

“…In Gaucher disease, ferritin levels are generally elevated without other biochemical evidence of iron overload, consistent with anemia of chronic disease, whereas typical iron deficiency anemia is characterized by low serum iron, low transferrin saturation and low ferritin levels [9]. In a study among Ashkenazi Jews, it was reported that vitamin B12 levels tended to be lower in the diseased population and decreased in the course of ERT [10]. We gave the patient parenteral vitamin B12 supplementation due to the low level.…”

Section: Discussionmentioning

confidence: 99%

Enzyme replacement therapy in type 1 Gaucher disease and a review of the literature

Kabaçam¹,

Kabacam²,

Topçuoğlu³

et al. 2010

Turk J Hematol

View full text Add to dashboard Cite

Gaucher disease (GD) is the most common lysosomal storage disorder. Deficiency of the lysosomal enzyme glucocerebrosidase results in the intracellular accumulation of undegraded substrates in the spleen, liver and bone marrow. Enzyme replacement therapy (ERT) is a standard approach for type 1 GD. Here, we present an adult patient with hematological disorders due to type 1 GD, who markedly improved with ERT. (Turk J Hematol 2010; 27: 190-5) Key words: Gaucher disease, glucosylceramidase, treatment

show abstract

High prevalence of low serum vitamin B₁₂ in a multi‐ethnic Israeli population

Cited by 48 publications

References 10 publications

High frequency of low serum levels of vitamin B [12] among patients attending Jordan University Hospital

High frequency of low serum levels of vitamin B [12] among patients attending Jordan University Hospital

Relationship between the Levels of Holotranscobalamin and Vitamin B12

Enzyme replacement therapy in type 1 Gaucher disease and a review of the literature

Contact Info

Product

Resources

About

High prevalence of low serum vitamin B12 in a multi‐ethnic Israeli population

Cited by 48 publications

References 10 publications

High frequency of low serum levels of vitamin B [12] among patients attending Jordan University Hospital

High frequency of low serum levels of vitamin B [12] among patients attending Jordan University Hospital

Relationship between the Levels of Holotranscobalamin and Vitamin B12

Enzyme replacement therapy in type 1 Gaucher disease and a review of the literature

Contact Info

Product

Resources

About

High prevalence of low serum vitamin B₁₂ in a multi‐ethnic Israeli population