High Prevalence of Low-Trauma Fracture in Chronic Pancreatitis

Abstract

The prevalence of low-trauma fracture in CP patients is comparable with or higher than that of "high-risk" GI illnesses, for which osteoporosis screening guidelines exist.

Bone mineral metabolism and bone mineral density in alcohol related and idiopathic chronic pancreatitis

“…Experimental models of inflammatory bowel disease have demonstrated immunemediated bone changes mediated by various inflammatory cytokines such as tumor necrosis factor-á, interleukins (IL-1â, IL-6) and interferon-ã. [18][19][20] Although the exact pathogenic mechanisms responsible for bone changes in chronic pancreatitis have still not been resolved, elevations in proinflammatory cytokines like IL-1, IL-6 and tumor necrosis factor-á have been described in CP patients. [20][21][22] Bone turnover is strongly regulated by the interactions between the receptor activator of nuclear factor-kB (RANK), the RANK ligand and osteoprotegerin.This system represents a crucial link between bone turnover and circulating cytokines.…”

Bone, Inflammation, and Inflammatory Bowel Disease

“…The prevalence of fragility fractures in patients with chronic pancreatitis is 4.8%, Crohn's disease (CD) 3.0%, celiac disease 5.0%, post gastrectomy 5.4%, versus controls 1.1%. The odds ratio (OR) of fractures in each group is significantly higher than in the control group (P<0.0001) [7] Children with IBD, even at the time of diagnosis, have mild cortical bone loss [8]. Similarly, children with celiac disease have a high prevalence of low bone mass at diagnosis [9].…”

Метаболічна Терапія В Комплексному Лікуванні Пацієнтів Із Коморбідністю Хронічного Панкреатиту Та стабільної Ішемічної Хвороби Серця

“…Неви-значеність цих механізмів залишає відкритими питан-ня медикаментозної терапії такого контингенту хворих, що в цілому знижує ефективність лікування хворих на СІХС. Тому пошук ефективних схем лікування у цьому напрямку є актуальним для сучасної медицини [18,19].…”