High Prevalence of Methicillin-Resistant Staphylococcus aureus in Emergency Department Skin and Soft Tissue Infections

Frazee, Bradley W.; Lynn, Jeremy V.; Charlebois, Edwin D.; Lambert, Larry; Lowery, Derrick; Perdreau-Remington, Françoise

doi:10.1016/j.annemergmed.2004.10.011

Cited by 440 publications

(316 citation statements)

References 50 publications

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“…Although such trials have failed to show reductions of SSIs among patients receiving mupirocin, the trend toward lower SSI rates has remained consistent. Adequate power required to show a reduction in SSI from a baseline of 3.2%, as in our study, would require thousands of patients, as SA nasal colonization is not invariably present in individuals with an active SA SSI [8], and decolonization is not 100% successful.…”

Section: Discussionmentioning

confidence: 99%

Staphylococcus aureus Nasal Colonization in Preoperative Orthopaedic Outpatients

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Williams

Philips

et al. 2008

Clinical Orthopaedics &Amp; Related Research

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Nasal colonization with Staphylococcus aureus (SA) increases the risk of surgical site infection (SSI). We first (1) determined the prevalence of asymptomatic nasal colonization with SA, (2) assessed trends in methicillin resistance with time, (3) ascertained risk factors for nasal colonization; and (4) correlated SSI to nasal colonization status and procedure. We performed a cross-sectional analysis of SA nasal colonization among healthy preoperative orthopaedic outpatients between 2003-2005 who were within 2 weeks of surgery. Of 284 patients, 86 (30%) carried SA; of these, 81 (94%) were colonized with methicillin-sensitive and five (6%) with methicillin-resistant SA (MRSA). Total SA colonization increased from 25/ 78 (32%) in 2003 to 37/97 (38%) in 2005, and colonization with MRSA increased from 0/78 (0%) to four of 97 (4%), respectively. We found no associations between nasal carriage and demographics or procedures. Surgical site infection occurred in nine of 282 (3%), four of which were attributable to SA; these included 0/43 (0%) carriers who received decolonization with 2% mupirocin, two of 43 (4.7%) who declined decolonization, and two of 196 (1.0%) who were noncarriers. Nasal colonization with SA, including MRSA, among preoperative orthopaedic outpatients is increasing and their rates reflect community rates. Knowledge of colonization status may be important in decolonization, choosing perioperative or any subsequent empiric antibiotics.

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Section: Discussionmentioning

confidence: 99%

Staphylococcus aureus Nasal Colonization in Preoperative Orthopaedic Outpatients

Price

Williams

Philips

et al. 2008

Clinical Orthopaedics &Amp; Related Research

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“…1,3,7,8,10 It is likely that attributing the wound to a spider bite occurs because the majority of these infections occur spontaneously 10 in younger, healthier patients. [11][12][13] In addition, these infections are also typically found on the extremities, 14 suggesting exposure to an insect. As the bites of Loxosceles and Cheiracanthium spp.…”

Section: Discussionmentioning

confidence: 99%

Reality bites of spider bites: a case report and review of the local epidemiology

Visser

Visser²

2013

Southern African Journal of Epidemiology and Infection

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“…Although we did not analyze these patients' MRSA isolates for the SCCmec IV allele or for genes for PVL, the biochemical profile, antibiogram, and cultural characteristics of the isolates were identical to those characterized by using pulsedfield gel electrophoresis and polymerase chain reaction. 1,3 In both studies, 1,3 99% of CA-MRSA isolates had the SCCmec IV allele and PVL genes and belonged to the USA300 pulsed-field type.…”

Section: Discussionmentioning

confidence: 99%

A Cluster of Fulminant, Fatal Necrotizing Community-Associated Methicillin-Resistant Staphylococcus aureus Pneumonias

Sohoni

Feeney

Lambert

et al. 2013

American Journal of Critical Care

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Community-associated methicillin-resistant Staphylococcus aureus is a frequent cause of skin and soft-tissue infections and is increasingly identified as a cause of pneumonia in immunocompetent patients. Panton-Valentine leukocidin, one of several leukocytotoxic peptides secreted by these cocci, is associated with increased virulence. A cluster of 3 unrelated patients with fatal pneumonia presumably caused by community-associated methicillin-resistant S aureus positive for Panton-Valentine leukocidin were treated in a 3-week period. Despite aggressive care and appropriate, timely administration of antibiotics, all 3 patients died. This article reviews the clinical and laboratory features suggestive of this lethal isolate, including unique findings on Gram stains of sputum.

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High Prevalence of Methicillin-Resistant Staphylococcus aureus in Emergency Department Skin and Soft Tissue Infections

Cited by 440 publications

References 50 publications

Staphylococcus aureus Nasal Colonization in Preoperative Orthopaedic Outpatients

Staphylococcus aureus Nasal Colonization in Preoperative Orthopaedic Outpatients

Reality bites of spider bites: a case report and review of the local epidemiology

A Cluster of Fulminant, Fatal Necrotizing Community-Associated Methicillin-Resistant Staphylococcus aureus Pneumonias

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