High Prevalence of Microchimerism in Female Patients

Vymětalová, Yevheniya; Bohuslavová, Romana; Hubacek, Jaroslav A.; Dufková, Blanka; Kocik, M.; Málek, I; Kautzner, Josef

doi:10.1016/j.transproceed.2008.06.103

Cited by 4 publications

(3 citation statements)

References 9 publications

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“…En transplantation cardiaque, 47,5 % des aortes de femmes donneuses (19 sur 40) contiennent des cellules XY [12]. Des cellules XY ont pu être identifié es dans les pré lè vements de cellules souches sanguines pré levé es pour transplantation chez plus d'un tiers des donneuses [13].…”

Section: Circonstances De Survenue Et Fre´quence Du Microchime´risme unclassified

Microchimérisme fœtal : un bien ou un mal pour le fœtus et sa mère ?

Boyon

Collinet

Boulanger

et al. 2011

Gynécologie Obstétrique & Fertilité

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Section: Circonstances De Survenue Et Fre´quence Du Microchime´risme unclassified

Microchimérisme fœtal : un bien ou un mal pour le fœtus et sa mère ?

Boyon

Collinet

Boulanger

et al. 2011

Gynécologie Obstétrique & Fertilité

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“…Les aortes thoraciques de 47,5 % femmes donneuses de greffon cardiaque contiennent des cellules XY dont l'origine n'a pas été précisée [17]. Des cellules XY ont pu être identifiées dans les prélèvements de cellules souches sanguines prélevées pour transplantation chez plus d'un tiers des donneuses [18].…”

Section: Circonstances De Survenue Et Fréquence Du Microchimérisme Founclassified

Microchimérisme fœtal : soi et non soi, finalement qui sommes-nous ?

Boyon

Vinatier

2011

Journal de Gynécologie Obstétrique et Biologie de la Reproducti

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“…In women, acquired chimerism has been detected after pregnancy, when embryonic cells from the fetus circulate and colonize tissues of the mother’s body. Maternal-fetal microchimerism may in fact be the most common form of chimerism found in humans [ 5 , 6 ]. Such chimerism could occur even if the pregnancy did not survive to recognition [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

A case of chimerism-induced paternity confusion: what ART practitioners can do to prevent future calamity for families

Sheets

Baird

Heinig

et al. 2017

J Assist Reprod Genet

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In the fertility clinic setting, a negative DNA paternity test result usually suggests a sample mix-up likely occurred at the testing company or in the clinic. However, we report a case where, despite repeat negative paternity test results, the alleged father (referred to as “the proband”) was confirmed to be the baby’s father. The proband, a 34 year-old male, contacted our research group when routine blood testing revealed discrepant blood types between the parents and the baby, repeat paternity tests were negative (excluding the proband as the baby’s father), and the fertility clinic found no evidence of any wrongdoing. Microarray technology was utilized to confirm biological relatedness, which revealed an avuncular (uncle/nephew) relationship. Additional tissue samples were analyzed and family studies were conducted at paternity and forensic laboratories using STR-based DNA tests to elucidate the proband’s condition of congenital tetragametic chimerism. His paternity was subsequently affirmed and the fertility clinic exonerated of claims of a semen sample mix-up. This case underscores the possibility that some allegations of fertility clinic missteps may be explained by undiagnosed chimerism, a condition where an individual harbors two distinct genomes. We offer specific suggestions for improving laboratory reporting and creating clinical guidelines to aid in identifying and rectifying future cases of false exclusions of paternity due to chimerism.Electronic supplementary materialThe online version of this article (10.1007/s10815-017-1064-6) contains supplementary material, which is available to authorized users.

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High Prevalence of Microchimerism in Female Patients

Cited by 4 publications

References 9 publications

Microchimérisme fœtal : un bien ou un mal pour le fœtus et sa mère ?

Microchimérisme fœtal : un bien ou un mal pour le fœtus et sa mère ?

Microchimérisme fœtal : soi et non soi, finalement qui sommes-nous ?

A case of chimerism-induced paternity confusion: what ART practitioners can do to prevent future calamity for families

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