High prevalence of multidrug-resistant Escherichia coli isolates from children with and without diarrhoea and their susceptibility to the antibacterial activity of extracts/fractions of fruits native to Mexico

Uribe-Beltrán, Magdalena de Jesús; Ahumada-Santos, Yesmi Patricia; Díaz‐Camacho, Sylvia Páz; Eslava-Campos, Carlos; Reyes-Valenzuela, Jesús Ernesto; Báez-Flores, María Elena; Osuna‐Ramírez, Ignacio; Delgado‐Vargas, Francisco

doi:10.1099/jmm.0.000548

Cited by 9 publications

(5 citation statements)

References 26 publications

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“…These activities may explain the dominant level of Escherichia in the infant gut 64,65 . Nevertheless, some strains of Fusobacterium and Escherichia are pathogenic and are associated with severe gastrointestinal diseases including inflammatory bowel disease 66 and diarrhea 67 , providing a new insight into the interplay between gut microbiota components and host immune system 68 . In the large intestine, Prevotella remained dominant at most time points (Fig.…”

Section: Discussionmentioning

confidence: 99%

Examination of the temporal and spatial dynamics of the gut microbiome in newborn piglets reveals distinct microbial communities in six intestinal segments

Liu

Zheng

et al. 2019

Sci Rep

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Intestinal microbiota plays a crucial role in immune development and disease progression in mammals from birth onwards. The gastrointestinal tract of newborn mammals is rapidly colonized by microbes with tremendous biomass and diversity. Understanding how this complex of segmental communities evolves in different gastrointestinal sites over time has great biological significance and medical implications. However, most previous reports examining intestinal microbiota have focused on fecal samples, a strategy that overlooks the spatial microbial dynamics in different intestinal segments. Using intestinal digesta from six intestinal segments (duodenum, jejunum, ileum, cecum, colon and rectum) of newborn piglets, we herein conducted a large-scale 16S rRNA gene sequencing-based study to characterize the segmental dynamics of porcine gut microbiota at eight postnatal intervals (days 1, 7, 14, 21, 28, 35, 120 and 180). A total of 4,465 OTUs were obtained and showed that the six intestinal segments could be divided into three parts; in the duodenum-jejunum section, the most abundant genera included Lactobacillus and Bacteroides ; in the ileum, Fusobacterium and Escherichia ; and in the cecum-rectum section, Prevotella . Although the microbial communities of the piglets were similar among the six intestinal segments on postnatal day 1, they evolved and quickly differentiated at later intervals. An examination of time-dependent alterations in the dominant microbes revealed that the microbiome in the large intestine was very different from and much more stable than that in the small intestine. The gut microbiota in newborn piglets exhibited apparent temporal and spatial variations in different intestinal segments. The database of gut microbes in piglets could be a referable resource for future studies on mammalian gut microbiome development in early host growth phases.

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Section: Discussionmentioning

confidence: 99%

Examination of the temporal and spatial dynamics of the gut microbiome in newborn piglets reveals distinct microbial communities in six intestinal segments

Liu

Zheng

et al. 2019

Sci Rep

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Section: E Colimentioning

confidence: 94%

“…Ciprofloxacin resistance increased from 2% to 9% in the AMR between 2003 and 2011 (Figure 3) [15,40]. Likewise, in the EMR, third generation cephalosporin resistance rose from low to moderate between 1996 and 2010, and then decreased drastically in 2016 (Figure 4) [15,20,44]. The third-generation cephalosporin resistance was 3.6% in 2016 in Hilla city, Iraq [20], whereas in Dhi Qar Governorate, Iraq, resistance to third-generation cephalosporin was 100% in 2019 [19] (Figure 4).…”

Section: E Colimentioning

confidence: 99%

Antibiotic resistance trends for common bacterial aetiologies of childhood diarrhoea in low- and middle-income countries: A systematic review

Neupane,

Bhathena,

Das

et al. 2023

J Glob Health

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Background Diarrhoea is the second most common cause of death among children under the age of five worldwide. The World Health Organization (WHO) recommends treating diarrhoea with oral rehydration therapy, intravenous fluids for severe dehydration, and zinc supplements. Antibiotics are only recommended to treat acute, invasive diarrhoea. Rising antibiotic resistance has led to a decrease in the effectiveness of treatments for diarrhoea.Methods A systematic literature review in PubMed, Web of Science, and EMBASE was conducted to identify articles relevant to antibiotic-resistant childhood diarrhoea. Articles in English published between 1990 to 2020 that described antibiotic resistance patterns of common pathogens causing childhood diarrhoea in low-and middle-income countries were included. The studies were limited to papers that categorized children as 0-5 years or 0-10 years old. The proportion of isolates with resistance to major classes of antibiotics stratified by major WHO global regions and time was determined. ResultsQuantitative data were extracted from 44 articles that met screening criteria; most focused on children under five years. Escherichia coli isolates had relatively high resistance rates to ampicillin and tetracycline in the African (AFR), American (AMR), and Eastern Mediterranean Regions (EMR). There was moderate to high resistance to ampicillin and third generation cephalosporins among Salmonella spp in the AFR, EMR, and the Western Pacific Region (WPR). Resistance rates for ampicillin, co-trimoxazole, and chloramphenicol for Shigella in the AFR started at an alarmingly high rate ( ~ 90%) in 2006 and fluctuated over time. There were limited antibiotic resistance data for Aeromonas, Yersinia, and V. cholerae. The 161 isolates of Campylobacter analysed showed initially low rates of fluoroquinolone resistance with high rates of resistance in recent years, especially in the Southeast Asian Region. ConclusionsResistance to inexpensive antibiotics for treatment of invasive diarrhoea in children under ten years is widespread (although data on 6-to 10-year-old children are limited), and resistance rates to fluoroquinolones and later-generation cephalosporins are increasing. A strong regional surveillance system is needed to carefully monitor trends in antibiotic resistance, future studies should include school-aged children, and interventions are needed to reduce inappropriate use of antibiotics for the treatment of community-acquired, non-invasive diarrhoea.Registration This systematic review was registered in Prospero (registration number CRD42020204004) in August 2020.

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“…Além de importante valor nutricional é um potencial fonte de fenóis, flavonóides, carotenóides, triterpenos, e constituintes de óleos essenciais (de Souza et al, 2018;Elizalde-González & Segura-Rivera., 2018). Na literatura, a P. guajava é amplamente estudada para tratamento de várias doenças como: infecções gastrointestinais, malária, diabetes, antifúngica, antiparasitária, antibacterianas, antivirais, problemas renais e vários outros (Daswani et al, 2017;Uribe-Beltrán et al, 2017;Massunari et al, 2017).…”

Section: Introductionunclassified

Potencial da planta Psidium guajava L. contra a doença de Alzheimer pela reversão do déficit de memória induzido por escopolamina

Silva

Santos²,

Costa³

et al. 2022

RSD

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A Doença de Alzheimer (DA) representa a principal causa de demência em todo o mundo. Exemplos de abordagens promissoras na investigação de produtos contra a DA é a avaliação in vitro da inibição da enzima acetilcolinesterase e da proteção contra o stress oxidativo induzido em células neuronais por H2O2, já utilizadas em extratos de P. guajava. Este trabalho tem o objetivo de avaliar in vivo a eficácia do extrato da folha de P. guajava na reversão do déficit de memória de trabalho induzida por escopolamina. Para tanto foram utilizados 33 camundongos Swiss, machos, albinos (35-45g). Animais controle (Ctr) receberam salina, o déficit de memória foi induzido por escopolamina 5 mg/kg (Esc). O extrato etanólico da folha de P. guajava (EFPG) foi diluído em etanol 5% em salina e administrado em duas diferentes concentrações (EFPG 1 e 10 mg/kg). A administração de escopolamina promoveu o déficit na memória de trabalho (alternações espontâneas: Ctr: 69,2 ± 4,9; Esc: 51,8 ± 5,0). Na dose de 10 mg/kg do EEPG, observou-se um bloqueio parcial do déficit de memória (Esc + EEPG 10: 62,6 ± 3,1). Não foram observadas alterações estatisticamente significativas entre os grupos quando se avaliou o número de entradas nos braços durante o teste (Eventos: Ctr: 22,9±2,7; Esc: 28,1±2,9; Esc + EEPG 1: 25,2±3,1; Esc + EEPG 10: 23,6±2,6). Como para o extrato da folha de P. guajava foi relatada atividade anticolinesterásica in vitro, o presente trabalho contribui para adicionar evidências do seu potencial terapêutico para o tratamento da Doença de Alzheimer.

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High prevalence of multidrug-resistant Escherichia coli isolates from children with and without diarrhoea and their susceptibility to the antibacterial activity of extracts/fractions of fruits native to Mexico

Cited by 9 publications

References 26 publications

Examination of the temporal and spatial dynamics of the gut microbiome in newborn piglets reveals distinct microbial communities in six intestinal segments

Examination of the temporal and spatial dynamics of the gut microbiome in newborn piglets reveals distinct microbial communities in six intestinal segments

Antibiotic resistance trends for common bacterial aetiologies of childhood diarrhoea in low- and middle-income countries: A systematic review

Potencial da planta Psidium guajava L. contra a doença de Alzheimer pela reversão do déficit de memória induzido por escopolamina

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