High prevalence of multidrug-resistant tuberculosis in Georgia

Mdivani, Nino; Zangaladze, Ekaterina; Volkova, Nataliya; Kourbatova, Ekaterina V.; Jibuti, Thea; Shubladze, Natalia; Kutateladze, Tamar; Khechinashvili, George; Rı́o, Carlos del; Salakaia, Archil; Blumberg, Henry M.

doi:10.1016/j.ijid.2008.03.012

Cited by 45 publications

(46 citation statements)

References 11 publications

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“…The high resistance of MTB to INH and RIF-the two main drugs in TB treatment-is an alarming sign. In other studies, SM and INH have been reported as more common compared to the other first-line drugs (21,22). Other patterns of anti-TB resistance also existed.…”

Section: Discussionmentioning

confidence: 83%

Drug-susceptibility Patterns of <i>Mycobacterium tuberculosis</i> in Mpumalanga Province, South Africa: Possible Guiding Design of Retreatment Regimen

Green

Obi

Nchabeleng

et al. 2010

J Health Popul Nutr

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Multidrug-resistant tuberculosis (MDR-TB) has been a cause of concern in both developed and developing countries. The prevalence of drug resistance in Mycobacterium tuberculosis (MTB) isolates (n=692) from Mpumalanga province was assessed. In total, 692 (64%) MTB strains from cases with pulmonary TB were tested for susceptibility against rifampicin, isoniazid, ethambutol, and streptomycin using the MGIT 960 instrument. Two hundred and nine (30.2%) strains were resistant to one or more drugs. Resistance to one drug ranged from 1.4% for ethambutol to 17.7% for rifampicin. The prevalence of MDR-TB ranged from 6.7% for three drugs to 34% for four drugs, with significant predictors being patients' age-groups of 25-54 years (p=0.0012) and >55 years (p=0.007). The result showed a high level (58.4%) of MDR-TB from cases in Mpumalanga province. To achieve a higher cure rate in this province, drug-susceptibility tests must be done for every case.

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Section: Discussionmentioning

confidence: 83%

Drug-susceptibility Patterns of <i>Mycobacterium tuberculosis</i> in Mpumalanga Province, South Africa: Possible Guiding Design of Retreatment Regimen

Green

Obi

Nchabeleng

et al. 2010

J Health Popul Nutr

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“…Another possible explanation for the association between intravenous drug use and drug resistant TB could be related to close contacts of drug users and transmission of resistant strains within this group [25] [27]. As we do not have genotyping data available, we cannot exclude the existence of possible clusters.…”

Section: Discussionmentioning

confidence: 99%

Risk Factors for Drug-Resistant Tuberculosis

Gomes¹,

Correia²,

Mendonça³

et al. 2014

JTR

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“…While rates of HIV infection in Georgia and Belarus are low, these former Soviet Union republics have in the past reported incredibly high rates of MDR-TB among both new (10.5% in Georgia and 35.5% in Belarus) and previously treated TB patients (53.1% Georgia and in 76.5% in Belarus). 16,17 These programs also share common features in their introduction of BDQ in their settings. Four of the five countries began using BDQ as part of compassionate use/expanded access programs, and a positive experience with the drug under these conditions led to the decision to scale up access to the drug more widely.…”

Section: Discussionmentioning

confidence: 99%

Examples of bedaquiline introduction for the management of multidrug-resistant tuberculosis in five countries

2017

Indian Journal of Tuberculosis

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SUMMARYBACKGROUND-For the first time in almost 50 years, there are new drugs available for the treatment of tuberculosis (TB), including bedaquiline (BDQ) and delamanid (DLM). The rate of introduction, however, has not kept pace with patient needs. It is estimated that as many as 23% of multidrug-resistant TB (MDR-TB) patients have an indication for receiving BDQ. As this is the first time the MDR-TB community is introducing new medications, it is important to understand how implementation can be developed in a variety of settings.

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High prevalence of multidrug-resistant tuberculosis in Georgia

Abstract: MDR-TB has emerged as a serious public health problem in Georgia and will greatly impact TB control strategies.

Cited by 45 publications

References 11 publications

Drug-susceptibility Patterns of <i>Mycobacterium tuberculosis</i> in Mpumalanga Province, South Africa: Possible Guiding Design of Retreatment Regimen

Drug-susceptibility Patterns of <i>Mycobacterium tuberculosis</i> in Mpumalanga Province, South Africa: Possible Guiding Design of Retreatment Regimen

Risk Factors for Drug-Resistant Tuberculosis

Examples of bedaquiline introduction for the management of multidrug-resistant tuberculosis in five countries

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