High prevalence of muscular ventricular septal defect in neonates

Roguin, Nathan; Du, Zhenhong; Barak, Moshe; Nasser, Nadim H; Hershkowitz, Silvia; Milgram, Elliot

doi:10.1016/0735-1097(95)00358-4

Cited by 202 publications

(137 citation statements)

References 18 publications

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“…8,22 Muscular ventricular defects, in particular, tend to be clinically mild or even asymptomatic and have been detected in as many as 5% of newborns screened by color-Doppler echocardiography. 24 The increased rate of atrioventricular septal defect among infants with Down syndrome in our study is consistent with previous reports 25 and also may reflect a more intensive or earlier cardiologic evaluation of affected pregnancies, newborns, or young infants. The racial variations in this study offer additional, if indirect, clues to understanding such time trends.…”

Section: Discussionsupporting

confidence: 82%

Racial and Temporal Variations in the Prevalence of Heart Defects

2001

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ABSTRACT. Background. Documenting the prevalence and trends of congenital heart defects provides useful data for pediatric practice, health-care planning, and causal research. Yet, most population-based studies use data from the 1970s and 1980s. We sought to extend into more recent years the study of temporal and racial variations of heart defects occurrence in a well-defined population.Methods. We used data from the Metropolitan Atlanta Congenital Defects Program, a population-based registry with active case ascertainment from multiple sources. Heart defects were identified among liveborn infants up to 1 year old, among stillborn infants, and among pregnancy terminations to mothers residing in metropolitan Atlanta.Results. From 1968 through 1997, the registry ascertained 5813 major congenital heart defects among 937 195 infants, for a prevalence of 6.2 per 1000. The prevalence increased to 9.0 per 1000 births in 1995 through 1997. The prevalence of ventricular septal defects, tetralogy of Fallot, atrioventricular septal defects, and pulmonary stenosis increased, whereas that of transposition of the great arteries decreased. For some defects, prevalence and trends varied by race.Conclusions. The prevalence of congenital heart defects is increasing. Whereas most findings likely result from improved case ascertainment and reporting, others might be because of changes in the distribution of risk factors in the population. The basis of the racial variations is incompletely understood. Pediatrics 2001;107(3). URL: http://www.pediatrics.org/cgi/content/full/107/3/ e32; heart defects, whites, blacks, epidemiology, prevalence.

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Section: Discussionsupporting

confidence: 82%

Racial and Temporal Variations in the Prevalence of Heart Defects

2001

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Section: Sources Of Datamentioning

confidence: 99%

“…small VSDs, 36 or have no functional effects on the heart. On the basis of the published literature, we assumed that the prevalence of ventricular septal defect would increase by 95% with echocardiography in the newborn period 36,273 and the prevalence of PDA, ASD, and PS by 61%. The 11 The number of defects that would be detecting using echocardiography in 100,000 liveborn infants is calculated and displayed in the three right-hand columns of the prevalence table in Appendix 8.…”

Section: Sources Of Datamentioning

confidence: 99%

Newborn screening for congenital heart defects: a systematic review and cost-effectiveness analysis

Knowles¹,

Griebsch²,

Dezateux

et al. 2005

Health Technol Assess

215

143

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“…Studies done on newborn infants, including some with no murmurs, found incidence of this heart defect to be from 2% to 5%. 8,9 About 85% to 90% of these defects close spontaneously by one year of age. 8,[10][11][12][13] In the initial stages, the shunt through the defect is from left ventricle to right.…”

Section: Discussionmentioning

confidence: 99%

Successful maternal outcome after vaginal delivery in a patient with Eisenmenger Syndrome

Chauhan

Agarwal

Gupta

et al. 2018

Int J Reprod Contracept Obstet Gynecol

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Patients with Eisenmenger syndrome are advised against pregnancy. Sometimes patients are diagnosed with Eisenmenger syndrome for the first time during pregnancy. This is what has happened in our case. A primigravida was diagnosed with ventricular septal defect with severe pulmonary artery hypertension for the first time during pregnancy at 34 weeks period of gestation. Management of such patients is challenging with different studies showing variable results. Here we describe such a case which was managed conservatively and was allowed to go into labour spontaneously with vacuum extraction during second stage which subsequently led to a favourable maternal outcome.

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High prevalence of muscular ventricular septal defect in neonates

Cited by 202 publications

References 18 publications

Racial and Temporal Variations in the Prevalence of Heart Defects

Racial and Temporal Variations in the Prevalence of Heart Defects

Newborn screening for congenital heart defects: a systematic review and cost-effectiveness analysis

Successful maternal outcome after vaginal delivery in a patient with Eisenmenger Syndrome

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