High prevalence of norovirus and rotavirus co‐infection in children with acute gastroenteritis hospitalised in Brazzaville, Republic of Congo

Abstract

objective To evaluate the clinical severity of diarrhoea associated to viral co-infection in children with acute gastroenteritis.methods About 461 children under five years hospitalised with acute diarrhoea (266 males and 187 females) were enrolled in the study. Using stool samples, rotavirus and adenovirus infections were investigated by ELISA, and norovirus infections by nested duplex RT-PCR. We assessed social, demographic, clinical and behavioural conditions that might influence the occurrence of rotavirus, adenovirus and norovirus infections.results Mono-viral infection was detected in 49% and mixed viral infection in 12% of patients. The prevalence of mixed infection was neither dependent on age nor sex. Three samples were infected with all three viruses. A significant association was found between fever (axillary temperature> 37.5°C) and rotavirus-norovirus dual infection (aOR (CI 95%) = 2.1 (1.14-3.84), P = 0.016; aOR (CI 95%) = 0.37 (0.19-0.73), P = 0.004). Mixed infection was the most common during the dry season from June to October (71.4% versus 54.7%, P = 0.023).conclusion Co-infection with both rotavirus and norovirus is common in under-five hospitalised children but does not contribute to the severity of the disease.

Rotavirus and Norovirus Infections in Children Under 5 Years Old with Acute Gastroenteritis in Southwestern China, 2018–2020

“…In the current study, the co-infection of rotavirus and norovirus was found to be 5.0%, which was higher than some previous studies [ 16 , 39 ]. The distribution of these co-infection cases was similar to that of either norovirus or rotavirus in terms of age and seasonality, which is consistent with data reported by Mikounou Louya et al [ 40 ]. The yearly co-infection rate showed a significant steady decrease during the study years, which may be related to the decreasing regional detection rate of rotavirus.…”

Epidemiological Characteristics and Genotypic Features of Rotavirus and Norovirus in Jining City, 2021-2022

“…Notably, Weishan County hosts one of Northern China's largest freshwater lakes, Weishan Lake, likely in uencing the distribution of RV-A and NV. Additionally, a signi cant number of diarrheal cases involved mixed RV-A and NV GII infections [20,25]. This study identi ed a substantial number of such cases, and their distribution mirrors patterns observed for norovirus and rotavirus in terms of age, month, and county.…”

Diarrhea: Novel Advances and Future Perspectives in the Etiological Diagnosis and Management

“…Acute diarrheal diseases ranked seventh among the reasons of mortality in LMIC in the international disorder burden collection, 2013, with an envisioned 1. Three million deaths (2 Four %).1 Most of those deaths arise in kids under the age of 5 years in LMIC and diarrhea stays among the top 5 causes of all deaths among children more youthful than age 5 years, as tabulated in 2013 [11][12][13][14][15][16][17][18][19][20].…”

“…The finding rate of norovirus cases associates definitely with humidity. Co-contamination with rotavirus [19,20], astrovirus, and salmonella both may occur in positive cases. Norovirus infections are discovered to reason greater excessive signs of gastroenteritis in children in comparison with rotavirus, especially after the advent of the rotavirus vaccination duration astrovirus.…”