High Prevalence of Oncogenic Human Papillomavirus in the Genital Tract of Women with Human Immunodeficiency Virus

Volkow, Patricia; Rubi, Sara; Lizano, Marcela; Carrillo, Adela L.; Vilar‐Compte, Diana; García‐Carrancá, Alejandro; Sotelo, Rita; Garcia, Berta; Sierra‐Madero, Juan; Mohar, Alejandro

doi:10.1006/gyno.2001.6244

Cited by 33 publications

(20 citation statements)

References 27 publications

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“…The distribution patterns with respect to age follow the patterns found in other studies , and the HIV prevalence found in this study correlates well with the prevalence described for rural Zimbabwe [Gregson et al, 2001]. As in other studies, we found a higher HPV prevalence in HIV positive women [Brinkman et al, 2002] than in those who were negative [Volkow et al, 2001;Gravitt et al, 2002]. Both HPV and HIV were associated with cell atypia.…”

Section: Discussionsupporting

confidence: 91%

“…Both HPV and HIV were associated with cell atypia. In studies on selected women with 75% low-grade squamous intraepithelial lesions or worse [Volkow et al, 2001] and 50% highgrade squamous intraepithelial lesions [Gravitt et al, 2002], HIV prevalences were 69 and 78.5%, respectively. High-grade squamous intraepithelial lesions were detected in less than 6% of our study population and in agreement with other studies, only high-risk HPV, and not HIV, remained significantly associated with cell atypia in multiple regression analysis .…”

Section: Discussionmentioning

confidence: 99%

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Human papillomavirus in a rural community in Zimbabwe: The impact of HIV co‐infection on HPV genotype distribution

Baay

Kjetland

Ndhlovu

et al. 2004

Journal of Medical Virology

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Cervical cancer is a leading cause of cancer-related deaths in developing countries, and the human papillomavirus (HPV) is linked etiologically to cervical cancer. Hence, a vaccine which prevents HPV-associated cervical cancer would have the most impact in developing countries, including the African continent. The type-specific immune response towards HPV virus-like particles, in combination with geographical variation in the prevalence of HPV, necessitates the presence of multiple HPV type antigens in a single vaccine cocktail in order to provide relevant protection. We aimed to investigate whether co-infection with HIV, which is highly prevalent in Africa, plays a role in HPV genotype distribution. After informed consent, HPV detection by GP5+/6+ PCR and HIV detection by serology was carried out on 236 women from the rural north-western part of Zimbabwe. The prevalence of HPV was higher in HIV positive women (54%) than in HIV negative women (27%). Certain HPV types (HPV types 11, 39, 43, 51, and 59, P-values ranging from 0.017 to 0.067) occurred more frequently in HIV positive women. Only high-risk HPV, and not HIV, was associated significantly with cervical intraepithelial neoplasia in multiple regression analysis. In conclusion, a high prevalence of HPV was found in a rural community, where regular Papanicolaou (Pap) smears would be a logistic and economic impossibility, but where free vaccination programmes against other infections are already established. The results suggest that HIV co-infection may have an impact on HPV genotype distribution.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Human papillomavirus in a rural community in Zimbabwe: The impact of HIV co‐infection on HPV genotype distribution

Baay

Kjetland

Ndhlovu

et al. 2004

Journal of Medical Virology

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“…In addition, Sitas et al [27] recently reported that HIV-1 infection was associated with a 1.6-fold-increased risk of prevalent ICC among Ugandan women. In contrast, in a case-control study from Mexico, no association was observed between HIV infection and risk of prevalent HSILs [42]. La Ruche et al [16] reported an increased risk of prevalent HSILs associated with HIV-1 but not HIV-2 infection, after adjustment for age.…”

Section: Discussionmentioning

confidence: 91%

Increased Risk of High‐Grade Cervical Squamous Intraepithelial Lesions and Invasive Cervical Cancer among African Women with Human Immunodeficiency Virus Type 1 and 2 Infections

et al. 2003

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To assess the risk of prevalent high-grade cervical squamous intraepithelial lesions (HSILs) or invasive cervical cancer (ICC) associated with human immunodeficiency virus (HIV) type 1, HIV-2, and human papillomavirus (HPV) infections, HIV load, and CD4 cell count, we studied 4119 women attending an outpatient clinic in Senegal. HIV infection was associated with increased rates of cervical infection with high-risk HPVs. Among women infected with high-risk HPVs, those with HIV-1 (odds ratio [OR], 2.2; 95% confidence interval [CI], 1.0-4.8), HIV-2 (OR, 6.0; 95% CI, 2.1-17.1), or dual HIV infection (OR, 8.0; 95% CI, 2.0-31.5) were more likely to have HSILs or ICC diagnosed than were HIV-negative women; this association was not observed among women not infected with high-risk HPVs. Among women with HIV, higher HIV plasma RNA loads and lower CD4 cell counts were associated with high-risk HPV infection and degree of cervical abnormality. Furthermore, HIV-2-positive women were more likely to have HSILs (OR, 3.3; 95% CI, 0.9-12.4) or ICC (OR, 7.9; 95% CI, 1.1-57) than were HIV-1-positive women.

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“…The incidence of this disease is increasing in the United States, Europe and South America, especially in the male population. In Mexico, cervical-uterine cancer remains a public health problem and patients infected with HIV, are at high risk of being infected with HPV, particularly with high risk subtypes, and develop invasive cervical carcinoma (Volkow et al 2001), that occurs in young women between the third and fourth decade of life and is clinically more aggressive. The most common morphological type is squamous cell carcinoma and there are no unique characteristics among carcinomas from patients without HIV.…”

Section: Other Malignancies (Carcinoma)mentioning

confidence: 99%

Surgical Pathology in HIV Infection in the Era of Antiretroviral Therapy

Romero-Guadarrama¹

2011

Recent Translational Research in HIV/AIDS

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High Prevalence of Oncogenic Human Papillomavirus in the Genital Tract of Women with Human Immunodeficiency Virus

Cited by 33 publications

References 27 publications

Human papillomavirus in a rural community in Zimbabwe: The impact of HIV co‐infection on HPV genotype distribution

Human papillomavirus in a rural community in Zimbabwe: The impact of HIV co‐infection on HPV genotype distribution

Increased Risk of High‐Grade Cervical Squamous Intraepithelial Lesions and Invasive Cervical Cancer among African Women with Human Immunodeficiency Virus Type 1 and 2 Infections

Surgical Pathology in HIV Infection in the Era of Antiretroviral Therapy

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