High prevalence of SHV-12 and the emergence of CTX-M-12 in clinical isolates of Klebsiella pneumoniae from Korea

Bae, Il Kwon; Lee, You Nae; Jeong, Seok Hoon; Lee, Kyungwon; Lee, Hyukmin; Kwak, Hyo Sun; Woo, Gun Jo

doi:10.1016/j.ijantimicag.2006.10.009

Cited by 5 publications

(2 citation statements)

References 6 publications

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“…CTX-M-12 ESBL differs from CTX-M-3 by three amino acid substitutions and has a high level of hydrolytic activity against cefotaxime compared with ceftazidime [13]. Since CTX-M-12 was first reported in K. pneumoniae isolates from Kenya in 2001 [13], and subsequently in Colombia in 2002 [26], it has been detected in clinical isolates from E. coli, K. pneumoniae, and Proteus mirabilis in Korea [2,3,23,24]. All of the isolates in this present study concomitantly produced TEM-1 beta-lactamase.…”

Section: Molecular Characterization Of Esbl Genesmentioning

confidence: 99%

Characterization of CTX-M-Type Extended-Spectrum Beta-Lactamase-Producing Diarrheagenic Escherichia coli Isolates in the Republic of Korea During 2008-2011

Kim¹,

Kim²,

Kim³

et al. 2014

Journal of Microbiology and Biotechnology

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To characterize the extended-spectrum beta-lactamases (ESBLs) in diarrheagenic Escherichia coli from Korea in 2008-2011, we screened seven enterotoxigenic E. coli (ETEC) and one enteroaggregative E. coli (EAEC) that produce ESBLs from a nationwide survey. All eight isolates produced CTX-M-type ESBLs, including CTX-M-12 (n = 4), CTX-M-14 (n = 2), and CTX-M-15 (n = 2). PCR-based replicon typing indicated that the blaCTX-M-12 genes of four ETEC isolates were carried on a conjugative IncF plasmid, whereas the blaCTX-M-14 of one EAEC was located on an IncK plasmid. This is the first report of the occurrence of blaCTX-M genes in clinical isolates of EAEC in Korea. The ESBL-producing isolates were shown to be different based on pulsed-field gel electrophoresis and multilocus sequence typing, whereas the four isolates with CTX-M-12 were clonally related. These observations raise an alarm for the spread of plasmid-mediated resistance to ESBL among diarrheagenic E. coli.

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Section: Molecular Characterization Of Esbl Genesmentioning

confidence: 99%

Characterization of CTX-M-Type Extended-Spectrum Beta-Lactamase-Producing Diarrheagenic Escherichia coli Isolates in the Republic of Korea During 2008-2011

Kim¹,

Kim²,

Kim³

et al. 2014

Journal of Microbiology and Biotechnology

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“…In Korea, the prevalence of extended-spectrum b-lactamases (ESBLs) in clinical Klebsiella pneumoniae isolates has been reported to be 17.7-30.0 % (Jeong et al, 2004;Kim et al, 2005;Ko et al, 2008a). SHV-12 is the most common ESBL in K. pneumoniae isolates from Korean hospitals followed by SHV-31, SHV-32 and TEM-52 and also CTX-M-type ESBLs, CTX-M-3, CTX-M-12, CTX-M-14 and CTX-M-15 (Bae et al, 2007;Jeong et al, 2004;Kim et al, 2005;Ko et al, 2008a;Ryoo et al, 2005). However, most of the previous studies in Korea have been performed on clinical isolates from patients irrespective of whether they cause disease.…”

Section: Introductionmentioning

confidence: 99%

Predominance of an ST11 extended-spectrum β-lactamase-producing Klebsiella pneumoniae clone causing bacteraemia and urinary tract infections in Korea

Lee

Baek

et al. 2010

Journal of Medical Microbiology

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To investigate the antimicrobial resistance, extended-spectrum b-lactamases (ESBLs) and clones of Klebsiella pneumoniae isolates causing bacteraemia or urinary tract infection (UTI) in Korea, a total of 406 K. pneumoniae isolates from patients with bacteraemia (221 isolates) and UTI (185 isolates) were collected from 10 tertiary-care Korean hospitals from July 2006 to October 2007. In vitro antimicrobial susceptibility testing was performed for all isolates and ESBL production was tested. Multilocus sequence typing (MLST) analyses were performed to characterize genotypes of ESBL-producing K. pneumoniae isolates. PFGE was performed for sequence type 11 (ST11) isolates. Forty-seven UTI isolates (25.4 %) produced ESBLs, while 30 bacteraemia isolates (13.6 %) produced ESBLs (P50.002). Among 77 ESBL-producing isolates, thirty-two (41.6 %) produced SHV-type ESBLs. bla CTX-M genes such as bla CTX-M-14 and bla CTX-M-15 were detected Abbreviations: ConNUH, Chonnam National University Hospital; CubNUH, Chungbuk National University Hospital; CunNUH, Chungnam National University Hospital; DFH, Daegu Fatima Hospital; ESBL, extended-spectrum b-lactamase; GNUH, Gyeongsang National University Hospital; JNUH, Jeju National University Hospital; KNUH, Kyungpook National University Hospital; KSH, Kangbuk Samsung Hospital; KUH, Konkuk University Hospital; MLST, multilocus sequence typing; SMC, Samsung Medical Center; ST, sequence type; UTI, urinary tract infection. Journal of Medical Microbiology(2010), 59, 822-828 DOI 10.1099

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Fecal carriage of extended-spectrum β-lactamase-producing Enterobacteriaceae in Korean community and hospital settings

Moon

Hur

et al. 2012

Infection

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High prevalence of SHV-12 and the emergence of CTX-M-12 in clinical isolates of Klebsiella pneumoniae from Korea

Cited by 5 publications

References 6 publications

Characterization of CTX-M-Type Extended-Spectrum Beta-Lactamase-Producing Diarrheagenic Escherichia coli Isolates in the Republic of Korea During 2008-2011

Characterization of CTX-M-Type Extended-Spectrum Beta-Lactamase-Producing Diarrheagenic Escherichia coli Isolates in the Republic of Korea During 2008-2011

Predominance of an ST11 extended-spectrum β-lactamase-producing Klebsiella pneumoniae clone causing bacteraemia and urinary tract infections in Korea

Fecal carriage of extended-spectrum β-lactamase-producing Enterobacteriaceae in Korean community and hospital settings

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