High prevalence of thyroid autoantibodies at diagnosis of insulin-dependent diabetes mellitus in Swedish children

Lindberg, Bengt; Ericsson, Ulla-Britt; Ljung, Rolf; Ivarsson, Sten

doi:10.1016/s0022-2143(97)90108-6

Cited by 35 publications

(17 citation statements)

References 26 publications

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“…Possible explanations for this difference could be ethnic variations, difference in iodine intake, a more sensitive assay in the latter study or alternatively immunological abnormalities present at diagnosis of IDDM before the start of insulin treatment. In accordance with Lindberg et al (7) we found antibody-positive patients in all age groups, which is in contrast to Lorini et al (21), who only found Tab in children older than 10 years. In our antibody-positive patients the duration of diabetes varied between 0.25 and 10 years.…”

Section: Discussionsupporting

confidence: 91%

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Thyroid function, morphology and autoimmunity in young patients with insulin-dependent diabetes mellitus

Hansen

Bennedbæk²,

Hansen³

et al. 1999

European Journal of Endocrinology

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Objective: An association between insulin-dependent diabetes mellitus (IDDM) and autoimmune thyroid disease is well recognized. We have studied the prevalence of thyroid dysfunction, autoimmunity and morphological abnormalities by ultrasonography in young diabetics. Subjects and methods: Among young IDDM patients less than 18 years old and living in the county of Funen, Denmark, 105 of 116 eligible patients participated. They were compared with 105 healthy children matched for sex and age. Routine thyroid function parameters (thyroxine (T 4 ), tri-iodothyronine (T 3 ), T 3 resin uptake and TSH) and thyroid autoantibodies (anti-thyroid peroxidase, TPOab, and thyroglobulin antibodies, Tgab) were measured. Thyroid size and morphology were determined by ultrasonography. Results: Two of the diabetics had previously diagnosed hypothyroidism and three new cases of subclinical hypothyroidism were found.

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Section: Discussionsupporting

confidence: 91%

“…In several studies of both children and adults with IDDM a high prevalence of thyroid autoantibodies (Tab) (8-44%) has been found as an indicator of thyroid autoimmune disease (1)(2)(3)(4)(5)(6)(7). Most of those antibody-positive diabetics were clinically and biochemically euthyroid.…”

Section: Introductionmentioning

confidence: 99%

Thyroid function, morphology and autoimmunity in young patients with insulin-dependent diabetes mellitus

Hansen

Bennedbæk²,

Hansen³

et al. 1999

European Journal of Endocrinology

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“…In the study by Premawardhana et al, patient and control groups had an anti-TG positivity of 25% and 33%, respectively, and for anti-TPO, these rates were as 22% and 18%, respectively; there was no statistical difference between these groups [22]. Previous studies have reported that TA is more frequent among girls than boys [21,23], while the present authors and others [19,24] have not found such a difference.…”

Section: Discussioncontrasting

confidence: 45%

Autoimmune thyroid disease in patients with anti-GAD positive type 1 diabetes mellitus

et al. 2009

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AbstractThe aim of the study was to determine the frequency and titers of anti-thyroid peroxidase (Anti-TPO), anti-thyroglobulin (Anti-TG), and anti-glutamic acid decarboxylase (Anti-GAD) antibodies in Turkish patients with type 1 diabetes mellitus (DM), and to compare the frequency of anti-TPO and anti-TG titers in the presence or absence of anti-GAD. A total of 104 patients including 56 males and 48 females with type 1 DM and their age-, gender-, and body mass index-matched control group, including 31 males and 27 females, 58 cases in total with an age range of 15-50 years, were recruited into this study. In patients with type 1 DM, positive anti-GAD was detected in 30.8% (n=32). In patients with positive anti-GAD, rate of positive anti-TPO was 37.5%; however, in patients with negative anti-GAD, the rate of positive anti-TPO was 9.7% and the difference was statistically significant (p=0.001). In patients with positive anti-GAD, the rate of positive anti-TG was 18.8%. In patients with negative anti-GAD, the rate of positive anti-TG was 2.8%, and the difference between them was statistically significant (p=0.005). In patients with positive and negative anti-GAD, rates of both positive anti-TPO and anti-TG were 15.6% and 1.4%, respectively, with the difference showing statistical significance (p=0.004). Thyroid autoimmunity in type 1 DM patients with positive anti-GAD was apparently higher; therefore, these patients should be followed more frequently and carefully.

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“…T1D is frequently associated with organ-specific autoimmune diseases, including autoimmune thyroid disease (AITD) and pernicious anemia (8,9). Abundant epidemiological data supports a genetic basis of T1D and AITD.…”

Section: Introductionmentioning

confidence: 99%

Organ Specific Autoantibodies in Preclinical and Early Clinical Type 1 Diabetes in Turkey

Erten¹,

Gürol²,

Deniz³

et al. 2007

Upsala Journal of Medical Sciences

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Type 1 diabetes mellitus (T1D) patients (G1; n=73) and first degree relatives with of FPIR (G2; n=18) were screened for two other autoantibodies, anti-glutamic acid decarboxylase (GADA) and insulin autoantibodies (IAA), and for other organ-specific autoantibodies, anti-gastric parietal cell (anti-PCA) and anti-thyroid peroxidase (anti-TPO) as well. The two control groups consisted of healthy subjects (G3; n:55 and G4; n:13). In G1, positivity of ICA, GADA, IAA, anti-TPO and anti-PCA were 63%, 75.1%, 27.4%, 17.8% and 8.2%, respectively. In G2, positivity for GADA, IAA, anti-TPO and anti-PCA were 55.6%, 11.1%, 16.7% and 11.1%, respectively. None of the anti-TPO or anti-PCA positive cases had clinical or laboratory thyroid disease or pernicious anemia.Other organ specific antibodies, in case they accompany GADA and/or IAA in high risk individuals, result in higher risk for T1D. Moreover, this condition may indicate future potential for developing thyrogastric autoimmune diseases.In conclusion; autoantibodies are markers for autoimmune destruction in T1D, and for identification of subjects at risk for disease. Even at the time of diagnosis of T1D, screening for thyrogastric autoimmunity might be recommended for early detection of the relevant diseases.

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High prevalence of thyroid autoantibodies at diagnosis of insulin-dependent diabetes mellitus in Swedish children

Cited by 35 publications

References 26 publications

Thyroid function, morphology and autoimmunity in young patients with insulin-dependent diabetes mellitus

Thyroid function, morphology and autoimmunity in young patients with insulin-dependent diabetes mellitus

Autoimmune thyroid disease in patients with anti-GAD positive type 1 diabetes mellitus

Organ Specific Autoantibodies in Preclinical and Early Clinical Type 1 Diabetes in Turkey

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