High prevalence of vitamin D deficiency and osteoporosis in patients with fragility fractures of hip: A pilot study

Abstract

Background: Vitamin D deficiency (VDD) is a major cause of poor bone health that could lead to fragility fractures, however, there is paucity of literature on prevalence of VDD and associated bone mass in patients of fragility fractures. Hip and spine are the commonest region affected by these fractures and the present study was conceptualised to ascertain the prevalence of VDD and bone mass in patients of hip fragility fractures (proximal femur) to evaluate their role in incidence of these fractures. Methods and materials: Between January 2013 and December 2013, 66 patients of fragility fractures around hip with age more than 50 years presented to our out patient department. Baseline evaluation of calcium profile, renal function tests, parathyroid hormone and 25(OH)D were done. All patients underwent DXA scan of the non -fractured hip. Results: Total number of male patients was 29 and females was 37, with mean age of 64.1 and 70.3 years, respectively. Intertrochanteric femur fractures were the most common type with 35 cases. Fall in bathroom was the most common mode of injury with 36 cases (54.5%). VDD was found in 74.2% of all patients. Prevalence of secondary hyperparathyroidism was observed in 27 patients. Osteopenia, osteoporosis and severe osteoporosis were observed in 15.2%, 62.1% and 18.2% of patients respectively. Sun light exposure was inadequate in 59% of patients with only 1 female patient having adequate exposure. Conclusion: Prevalence of Vitamin D deficiency is very high in patients with hip fragility (proximal femur) fractures with secondary hyperparathyroidism and osteoporosis commonly associated. These fractures in our part of the world, occur at a younger age group as compared to the Western population. Majority of the patients sustain in-house fractures.

Menopause-Associated Lipid Metabolic Disorders and Foods Beneficial for Postmenopausal Women

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“…Hip fractures present as one of the commonest injuries in the geriatric population with a reported incidence between 1 and 2% across Europe and the United States of America [ 1 ]. Factors related to increased age; osteoporosis, vitamin D deficiency, and multiple systemic comorbidities, make these patients prone to fragility fractures, as well as increase the associated morbidity and mortality [ 1 , 2 ]. Surgical management is favoured in these patients for early mobilization to prevent repercussions associated with prolonged bed rest; bed sores, deep vein thrombosis or venous thromboembolism and cardiopulmonary insult [ 3 ].…”

Abnormal expression of miR‑135b‑5p in bone tissue of patients with osteoporosis and its role and mechanism in osteoporosis progression

“…As a bone disease, the main characteristics of OP include low bone density, easy bone damage, decreasing bone mass and increased risk of fracture (6). Hip fractures are frequently observed in patients with OP (7). Diagnosis of OP is very difficult until a fracture occurs (8).…”