2017
DOI: 10.5935/1518-0557.20170004
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High Progesterone levels in the beginning of ICSI antagonist cycles and clinical pregnancy: still a concern?

Abstract: ObjectiveIn controlled ovarian hyperstimulation (COH) using antagonist cycles, an incomplete luteolysis could happen after an inefficient previous luteolysis. Since antagonist cycles are frequent today, this study aims to access the impact of serum progesterone in the beginning and at the end of stimulation, and pregnancy outcomes.Methodssingle-center cohort study, 461 fresh embryo transfers in ICSI antagonist cycles. Serum progesterone levels was measured in the beginning of COH (P4i) and on hCG day (P4f) usi… Show more

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Cited by 8 publications
(7 citation statements)
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“…It is known that an embryo implanted in an endometrium with early luteinization has a decrease in its fixation rate. Thus, once this diagnosis is confirmed, it is possible to freeze this embryo or even the oocytes and organize a new cycle for transfer with better conditions for obtaining the pregnancy ( Panaino et al , 2017 ).…”
Section: Discussionmentioning
confidence: 99%
“…It is known that an embryo implanted in an endometrium with early luteinization has a decrease in its fixation rate. Thus, once this diagnosis is confirmed, it is possible to freeze this embryo or even the oocytes and organize a new cycle for transfer with better conditions for obtaining the pregnancy ( Panaino et al , 2017 ).…”
Section: Discussionmentioning
confidence: 99%
“…Elevated levels of P4 were observed in greater numbers in pregnant women at this study. In the literature, serum progesterone above 1.5 ng/ml on the day of the oocyte trigger suggests early luteinization, indicating embryo freezing and transfer to another cycle to potentiate the result (Panaino et al, 2017). A P4 dosage of 10 ng/ml on D4 after the trigger in frozen embryo transfer provides better pregnancy rates (Gaggiotti-Marre et al, 2020).…”
Section: Discussionmentioning
confidence: 99%
“…Some values of hormone dosages are established. On the human chorionic gonadotropin (hCG) day, values above 1.5ng/ml indicate early endometrial luteinization, allowing the choice to freeze the embryos and transfer them in another cycle (Panaino et al, 2017). In frozen embryo transfer, P4 values greater than 10 ng/ml on Day 4 (D4) of embryonic evolution are described as a predictor of success (Gaggiotti-Marre et al, 2019).…”
Section: Introductionmentioning
confidence: 99%
“…For t-NC, transvaginal ultrasonography is performed on day 2 or 3 of menses to rule out any cyst or corpus luteum prevailing from the previous cycle. Cycle cancellation is usually undertaken in cycles with serum P 4 >1.5 ng/ml on day 2 or 3 of menses, even though this practice has been extrapolated from fresh embryo transfer cycles (48,49). To our knowledge, there is no study evaluating the impact of day 2/3 serum P 4 on success rates in t-NC, modified-NC, and mild-OS cycles.…”
Section: True-nc (T-nc)mentioning
confidence: 99%