2020
DOI: 10.1016/j.jgar.2019.09.007
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High proportion of carbapenemase-producing Escherichia coli and Klebsiella pneumoniae among extended-spectrum β-lactamase-producers in Nigerian hospitals

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Cited by 36 publications
(32 citation statements)
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“…In this study, the presence of bla NDM-5 and bla OXA-181 accounted for carbapenem resistance in about a third of the CRE isolates. This corresponds to the findings of previous studies in different regions of Nigeria where bla NDM-5 , bla OXA-48 and bla OXA-181 have been reported as the commonest carbapenemase genes [ 38 , 39 ]. Our findings, however, contrasted the report of a study in Maiduguri, northeast Nigeria, where bla KPC has been reported as the predominant carbapenemase gene [ 40 ].…”
Section: Discussionsupporting
confidence: 91%
“…In this study, the presence of bla NDM-5 and bla OXA-181 accounted for carbapenem resistance in about a third of the CRE isolates. This corresponds to the findings of previous studies in different regions of Nigeria where bla NDM-5 , bla OXA-48 and bla OXA-181 have been reported as the commonest carbapenemase genes [ 38 , 39 ]. Our findings, however, contrasted the report of a study in Maiduguri, northeast Nigeria, where bla KPC has been reported as the predominant carbapenemase gene [ 40 ].…”
Section: Discussionsupporting
confidence: 91%
“…Multiplex PCR screening identi ed carbapenemase encoding genes in 33.0% of the isolates. This genotypic carbapenem resistance prevalence corroborates with earlier studies conducted in the East African region [18,25,38] and elsewhere [27,39] that reported levels ranging from 25% to 40%. Contrary, this frequency is signi cantly lower than carbapenem genotypic levels reported by studies in Tunisia (76.7%) [40], South Africa (68% and 86%) [33,34] , Egypt (89.6%) [37], Turkey (49.5%) [41].…”
Section: Discussionsupporting
confidence: 91%
“…Comparable results were achieved by previous studies in Low Middle Income countries (LMIC) with similar healthcare systems. For example, prevalence of carbapenem resistance in Tanzania was 24% [25], Nigeria 15.2%, 27.4% and 36.8%) [26][27][28], India 31.77% [29]. Contrary, this frequency is higher than carbapenem resistance levels reported in countries like Ghana (7.2%) [30], Morocco 5.99% [31], and Ethiopia 2.73%, [32] with similar healthcare settings but lower than the incidences above 50% reported in South Africa, Egypt and Tunisia [33][34][35][36][37].…”
Section: Discussionmentioning
confidence: 99%
“…pneumoniae ST395 may be a major carbapenemase-producing clone in Nepal. K. pneumoniae ST395 clinical isolates have been detected in China (Yang et al, 2013), (Liapis et al, 2014), Hungary (Kovacs et al, 2017), Italy (Mezzatesta et al, 2014), Nigeria (Olalekan et al, 2019), Poland (Alekseeva et al, 2017), Russia (Ageevets et al, 2014) and Yemen (Alsharapy et al, 2019), with most of these producing carbapenemases, including KPC-2 and OXA-48. Although ST11, ST14, ST101, ST147 and ST258 are major carbapenemase-producing clones, no report to date has described a strain of K. pneumoniae ST395 co-harboring bla NDM-5 and bla OXA-48-like .…”
Section: Discussionmentioning
confidence: 99%