High Protein Diet that Cause Weight Loss and Lower Blood Glucose Level Have a Serious Impact on the Kidney Functions of Male Diabetic Obese Albino Rats

Abstract

Background: High protein (HP) diets are increasingly being recommended as one of the management strategies for weight control in overweight and obese individuals. The health benefits of high protein diets are well-established, but the mechanisms of action on body systems responsible for the changes in body weight and glycaemic control are not well-clear. Objective: The present study aimed to examine the effect of HP diets on the kidney functions of diabetic obese albino rats. Material and Methods: Eighty male adult male albino rats were used in this study. The animals were divided into eight equal groups (10 rats for each). Type 2 DM and obesity were induced. At the end of the 12 weeks, samples were collected for biochemical analysis. Results: The high protein diet led to significant decrease in BW, FI, BG, TC, LDL, TG, Lactate dehydrogenase, albumin, urine pH and urine citrate; while serum insulin, HDL, urea, creatinine, total protein, urine volume and urinary excretion of Ca were significantly higher in high protein diet groups. Conclusion: A high protein intake in diabetic obese albino rats for 12 weeks led to changes in the serum and urine levels of markers of renal function which indicated abnormalities in the functions of the kidney.

A 90‐day toxicity study of tripeptide, arginine‐alanine‐lysine

“…In females, there was a dose‐dependent decrease in glucose, but the results were within the historical control ranges and without correlative findings; and were, therefore, considered without toxicological relevance. Dose‐dependent decreases in LDL and glucose have been associated with a high protein diet in rodent studies (El‐Deen et al, 2018; Jean et al, 2001). The dose‐dependent change in TBIL, which was within historical control range, was considered artifactual because the control was high and outside the historical control range.…”