High-Protein Low-Carbohydrate Diets Enhance Weight Loss in Dogs

Bierer, Tiffany L.; Bui, Linh M.

doi:10.1093/jn/134.8.2087s

Cited by 21 publications

(19 citation statements)

References 8 publications

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“…, 1994). The present data show that weight loss was greatest (5.0–7.7%) in the first 4 weeks – a pattern that has also been observed with dietary restriction (Bierer & Bui, 2004). Throughout the weight‐loss phase, incremental increases in the mean dose for dirlotapide‐treated dogs were necessary to achieve and maintain target rates of weight loss.…”

Section: Discussionsupporting

confidence: 86%

Evaluation of dirlotapide for sustained weight loss in overweight Labrador retrievers

Gossellin

Peachey

Sherington

et al. 2007

Vet Pharm & Therapeutics

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The effects of dirlotapide on body weight (BW) reduction were investigated in overweight Labradors in two parallel-design studies. Study A involved 42 dogs randomized to 0.0, 0.025, 0.05, 0.1, 0.2 or 0.4 mg dirlotapide/kg/day orally for 4 weeks. Study B involved 72 dogs randomized to nine treatments: placebo (24 weeks); dirlotapide (24 weeks) followed by placebo (28 weeks); or dirlotapide (52 weeks); on diets containing 5%, 10% or 15% fat. Dirlotapide dose (initially 0.1 mg/kg) was adjusted monthly during 24-week weight-loss and subsequent 28-week weight-stabilization phases. Food was offered above maintenance energy requirements (MERx 1.1-1.2) based on initial BW. Body composition (body fat, lean tissue and bone mineral content) was monitored using dual-energy X-ray absorptiometry. After treatment, dogs that had received dirlotapide for 52 weeks were fed 90% of quantity consumed at week 52. In study A, BW and food intake decreased asymptotically with dose: mean weekly weight loss exceeded 1% at 0.1-0.4 mg/kg. In study B, dirlotapide resulted in significant mean weekly weight loss (>0.8%) and decreased food intake over 24 weeks compared with placebo (P = 0.0001) for all diets. Food restriction minimized post-treatment weight rebound. Dirlotapide administered daily to dogs for up to 52 weeks was clinically safe and resulted in sustained weight reduction.

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Section: Discussionsupporting

confidence: 86%

Evaluation of dirlotapide for sustained weight loss in overweight Labrador retrievers

Gossellin

Peachey

Sherington

et al. 2007

Vet Pharm & Therapeutics

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“…HPLC diets have been promoted as an effective body weight management strategy for many years, and potential benefits were reported in both humans and animals (20–23). However, little is known on how the dietary protein-to-carbohydrate ratio influences gut microbiotas in dogs.…”

Section: Discussionmentioning

confidence: 99%

“…The concept of using high-protein, low-carbohydrate (HPLC) diets for body weight loss has been promoted as an effective weight loss strategy for many years (20). Potential benefits of HPLC diets, including increased satiety, reduced hunger, and preservation of lean body mass during body weight reduction, were reported for both humans and dogs (21–23). In rats, an HPLC diet appears to be effective in reducing both caloric intake and body weight gain (24).…”

Section: Introductionmentioning

confidence: 99%

Effects of the Dietary Protein and Carbohydrate Ratio on Gut Microbiomes in Dogs of Different Body Conditions

Li¹,

Lauber

Czarnecki-Maulden³

et al. 2017

mBio

120

108

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Obesity has become a health epidemic in both humans and pets. A dysbiotic gut microbiota has been associated with obesity and other metabolic disorders. High-protein, low-carbohydrate (HPLC) diets have been recommended for body weight loss, but little is known about their effects on the canine gut microbiome. Sixty-three obese and lean Labrador retrievers and Beagles (mean age, 5.72 years) were fed a common baseline diet for 4 weeks in phase 1, followed by 4 weeks of a treatment diet, specifically, the HPLC diet (49.4% protein, 10.9% carbohydrate) or a low-protein, high-carbohydrate (LPHC) diet (25.5% protein, 38.8% carbohydrate) in phase 2. 16S rRNA gene profiling revealed that dietary protein and carbohydrate ratios have significant impacts on gut microbial compositions. This effect appeared to be more evident in obese dogs than in lean dogs but was independent of breed. Consumption of either diet increased the bacterial evenness, but not the richness, of the gut compared to that after consumption of the baseline diet. Macronutrient composition affected taxon abundances, mainly within the predominant phyla, Firmicutes and Bacteroidetes. The LPHC diet appeared to favor the growth of Bacteroides uniformis and Clostridium butyricum, while the HPLC diet increased the abundances of Clostridium hiranonis, Clostridium perfringens, and Ruminococcus gnavus and enriched microbial gene networks associated with weight maintenance. In addition, we observed a decrease in the Bacteroidetes to Firmicutes ratio and an increase in the Bacteroides to Prevotella ratio in the HPLC diet-fed dogs compared to these ratios in dogs fed other diets. Finally, analysis of the effect of diet on the predicted microbial gene network was performed using phylogenetic investigation of communities by reconstruction of unobserved states (PICRUSt).

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“…101,113,114 For example, overweight cats fed restricted amounts of a food containing 46% of ME as protein lost more body fat and retained more lean body tissue than did cats fed the same amount (calories) of a food containing 36% protein, even though overall weight change was the same between the two groups. Studies with both dogs and cats have shown that increasing protein in weight-loss diets improves body composition; increased body fat is lost while loss of lean body tissue is minimized.…”

Section: Dietary Fatmentioning

confidence: 99%

Development and Treatment of Obesity

Case¹

2011

Canine and Feline Nutrition

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High-Protein Low-Carbohydrate Diets Enhance Weight Loss in Dogs

Cited by 21 publications

References 8 publications

Evaluation of dirlotapide for sustained weight loss in overweight Labrador retrievers

Evaluation of dirlotapide for sustained weight loss in overweight Labrador retrievers

Effects of the Dietary Protein and Carbohydrate Ratio on Gut Microbiomes in Dogs of Different Body Conditions

Development and Treatment of Obesity

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