High Pulse Wave Velocity Has a Strong Impact on Early Carotid Atherosclerosis in a Japanese General Male Population

Kubozono, Takuro; Miyata, Masaaki; Kawasoe, Shin; Ojima, Satoko; Yoshifuku, Shiro; Miyahara, Hirofumi; Maenohara, Shigeho; Ohishi, Mitsuru

doi:10.1253/circj.cj-16-0687

Cited by 28 publications

(31 citation statements)

References 35 publications

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“…There was also a higher prevalence of arterial stiffness for individuals with dyslipidemia, which is concordant with the cohort study performed by Blacher et al [31] with 710 individuals, demonstrating that the PWV values were higher in the presence of atherosclerosis, with cardiovascular risk increasing in the measure in which there is an increase in the PWV. Kubozono et al [45] also demonstrated an association between early atherosclerosis and altered PWV, contrary to our study, which did not demonstrate such association. Arterial stiffness can be compromised by atherosclerosis involving not only biological senility, but various external factors capable of decreasing the complacency of the arteries, among which are dyslipidemia and consequent atherosclerosis [46].…”

Section: Discussioncontrasting

confidence: 99%

Analysis of Vascular Aging in Arterial Hypertension — Population-based Study: Preliminary Results

Costa¹,

Cunha²,

Filho³

et al. 2019

Artery Res

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Background: Arterial Hypertension (AH) is an uncertain and complex physiopathological disease with the Arterial Stiffness (AS) as one of the main cardiovascular alterations. Pulse Wave Velocity (PWV) is the gold standard marker for assessment of the vascular aging and an important predictor of cardiovascular risk. Methods: Cross-sectional population-based studies, in the restricted area of Vale do Ogunjá, Salvador-Bahia. Sociodemographic data, through questionnaire and clinical data were obtained. A PWV was evaluated by applanation tonometry using the device SphygmoCor® (AtCor Medical Pty Ltd, New South Wales, Australia). Frequency and descriptive measurements of central and dispersion were obtained, and the Chi-square test to statistical analysis. Results: PWV presented a higher mean in hypertensive patients (10.0 ± 2.2 m/s). There was a higher prevalence of AS in male individuals with advanced age and presence of risk factors. The prevalence ratio of AS was 3.7 times higher in hypertensive patients (p = 0.002; 95% CI: 1.6-8.5) and 7.5 times higher in patients aged above 40-74 years (p = 0.015; 95% CI: 2.4-23.1). Conclusion: There was an important relation between AS and increased of PWV in the presence of hypertension. The relevance of this study is associated with the use of non-invasive clinical evaluation of PWV, contributing to improve morbidity and mortality in hypertensive patients.

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Section: Discussioncontrasting

confidence: 99%

Analysis of Vascular Aging in Arterial Hypertension — Population-based Study: Preliminary Results

Costa¹,

Cunha²,

Filho³

et al. 2019

Artery Res

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“…Several published papers have investigated the association of arterial stiffness assessed by baPWV and carotid atherosclerosis. Kubozono et al [22] found that high baPWV had a strong impact on early carotid atherosclerosis (defined as CIMT ≥1.0 mm) in a Japanese general male population. Munakata et al [23] reported that higher baPWV was associated with greater max CIMT or carotid plaque score in patients with end-stage renal disease.…”

Section: Discussionmentioning

confidence: 99%

Association of brachial–ankle pulse wave velocity and carotid plaque in Chinese hypertensive adults: effect modification by age

et al. 2020

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We aimed to investigate the association of brachial-ankle pulse wave velocity (baPWV) with carotid plaque presence and carotid plaque number in a Chinese hypertensive population. A total of 13,554 hypertensive subjects from the China Stroke Primary Prevention Trial (CSPPT) were recruited. Arterial stiffness and carotid plaque were evaluated by baPWV and B-mode ultrasonography, respectively. Multivariate logistic regression analysis was used to determine the correlation of baPWV and carotid plaque presence. Multinomial logistic regression analysis was used to determine the correlation of baPWV and carotid plaque number. Further interactions between baPWV and carotid plaque presence were examined using subgroup analysis. Continuous baPWV was positively correlated with carotid plaque presence (OR = 1.05, 95% CI: 1.04-1.07) and carotid plaque number (one-to two-plaque group: OR = 1.04, 95% CI: 1.02-1.06; three-or-more-plaque group: OR = 1.09, 95% CI: 1.07-1.12). When baPWV was classified into quartiles, with the lowest quartile as reference, the ORs for having one, two, or three or more plaques increased in parallel with the quartiles of baPWV, indicating a dosedependent effect. In a subgroup analysis, the association of baPWV and carotid plaque presence was more pronounced among younger participants (OR: 1.14 vs. 1.06 and 1.03 for the age groups <60 years, 60 ≤ 70 years, and ≥70 years, respectively, P for interaction <0.001). In a Chinese hypertensive population, baPWV was positively associated with carotid plaque presence and carotid plaque number. A more pronounced positive association between baPWV and carotid plaque presence was observed in younger participants. Keywords Brachial-ankle pulse wave velocity • Carotid plaque presence • Carotid plaque number • Hypertension • Age

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“…As previously reported, 5,8,10,11) baPWV was measured and calculated using an automatic waveform analyzer (model BP-203RPE; Colin Co., Komaki, Japan). This instrument simultaneously recorded venous blood pressure, phonocardiogram, electrocardiogram, and arterial blood pressure in both upper arms and ankles.…”

Section: Brachial-ankle Pulse Wave Velocity Measurementmentioning

confidence: 99%

“…Moreover, high baPWV was a strong predictor of early carotid atherosclerosis. 8) A baPWV of >1,400 cm/s is an independent risk factor for moderate risk (≥10%) stratification according to the Framingham risk scoring system, and a baPWV of >1,600 cm/s is an independent factor for high risk stratification according to the European systematic coronary risk evaluation (SCORE) system. 9) Although high MCV has been implicated in various health problems, the clinical significance of borderline-high MCV is poorly understood among apparently healthy Korean individuals in the primary care setting.…”

Section: Introductionmentioning

confidence: 99%

Borderline-High Mean Corpuscular Volume Levels Are Associated with Arterial Stiffness among the Apparently Healthy Korean Individuals

Kwon

Park

2020

Korean J Fam Med

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Background: High mean corpuscular volume (MCV) has been implicated in various health problems, such as anemia, liver disease, and thyroid disease. However, the clinical significance of borderline-high MCV is poorly understood in the primary care setting. This study aimed to investigate whether borderline-high MCV was related to arterial stiffness in Korean adults as measured by brachial-ankle pulse wave velocity (baPWV). Methods: This cross-sectional study comprised 582 participants aged >30 years who underwent routine health examinations. Borderline-high MCV was defined as over 95.0 fl (>90th percentile) after excluding participants with MCV of ≥100 fl or ≤80 fl, and high baPWV was defined as >1,600 cm/s (>90th percentile). The odds ratios (ORs) and 95% confidence intervals (CIs) for high baPWV according to borderline-high MCV were calculated using multiple logistic regression analyses after adjusting for the confounding variables. Results: The mean age of the study population was 47.8±11.7 years, and 56.9% of the participants were male. Compared to that in the control group, the OR (95% CI) of high baPWV in those with a borderline-high MCV was 3.68 (1.39-9.74) after adjusting for age, sex, body mass index, alcohol intake, smoking status, regular exercise, mean blood pressure, fasting plasma glucose, triglyceride, high-density lipoprotein cholesterol, C-reactive protein, γ-glutamyltransferase, uric acid, hypertension medication, and diabetes medication. Conclusion: Borderline-high MCV was independently associated with arterial stiffness among apparently healthy Korean individuals.

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High Pulse Wave Velocity Has a Strong Impact on Early Carotid Atherosclerosis in a Japanese General Male Population

Cited by 28 publications

References 35 publications

Analysis of Vascular Aging in Arterial Hypertension — Population-based Study: Preliminary Results

Analysis of Vascular Aging in Arterial Hypertension — Population-based Study: Preliminary Results

Association of brachial–ankle pulse wave velocity and carotid plaque in Chinese hypertensive adults: effect modification by age

Borderline-High Mean Corpuscular Volume Levels Are Associated with Arterial Stiffness among the Apparently Healthy Korean Individuals

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