High-purity weight-bearing magnesium screw: Translational application in the healing of femoral neck fracture

Huang, Shibo; Wang, Benjie; Zhang, Xiuzhi; Lu, Fangfang; Wang, Zongpu; Tian, Simiao; Li, Dongyi; Yang, Jiahui; Cao, Fang; Cheng, Liang; Gao, Ziqi; Li, Yangde; Qin, Kairong; Zhao, Dewei

doi:10.1016/j.biomaterials.2020.119829

Cited by 67 publications

(64 citation statements)

References 29 publications

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“…In the current study, the degradation rate of our Mg pin was a decrease in volume of the pin by 22.4% at week 8 and 54.8% at week 12. Huang et al implanted high purity Mg screw for fixation of femoral neck fracture in goats and they reported that the degradation rate was decrease in volume of the pin by 10% at week 4 and 38.8% at week 12 [ 36 ]. Zhao et al implanted pure Mg (99.99%) screw for fixation of a vascularized bone graft to treat osteonecrosis of femoral head in humans [ 36 ].…”

Section: Discussionmentioning

confidence: 99%

“…Huang et al implanted high purity Mg screw for fixation of femoral neck fracture in goats and they reported that the degradation rate was decrease in volume of the pin by 10% at week 4 and 38.8% at week 12 [ 36 ]. Zhao et al implanted pure Mg (99.99%) screw for fixation of a vascularized bone graft to treat osteonecrosis of femoral head in humans [ 36 ]. They reported that the average reduction percentage of Mg screw diameter was 3.7%, 9.3%, 13.7% and 25.2% at 1, 3, 6, and 12 months, postoperatively [ 36 ].…”

Section: Discussionmentioning

confidence: 99%

“…Zhao et al implanted pure Mg (99.99%) screw for fixation of a vascularized bone graft to treat osteonecrosis of femoral head in humans [ 36 ]. They reported that the average reduction percentage of Mg screw diameter was 3.7%, 9.3%, 13.7% and 25.2% at 1, 3, 6, and 12 months, postoperatively [ 36 ]. Wang et al implanted high purity Mg interference screw for anterior cruciate ligament reconstruction in rabbits and reported that the degradation rate of the interference screw was decrease in volume of the screw by 10% after 16 weeks post-operation [ 36 ].…”

Section: Discussionmentioning

confidence: 99%

“…They reported that the average reduction percentage of Mg screw diameter was 3.7%, 9.3%, 13.7% and 25.2% at 1, 3, 6, and 12 months, postoperatively [ 36 ]. Wang et al implanted high purity Mg interference screw for anterior cruciate ligament reconstruction in rabbits and reported that the degradation rate of the interference screw was decrease in volume of the screw by 10% after 16 weeks post-operation [ 36 ]. One of the reasons that the current study demonstrated faster degradation of the Mg implant was the presence of implants that are made of another metal, which is the stainless steel wire for the tension band.…”

Section: Discussionmentioning

confidence: 99%

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Biodegradable magnesium pins enhanced the healing of transverse patellar fracture in rabbits

Chow

Wang

Wan

et al. 2021

Bioactive Materials

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Displaced fractures of patella often require open reduction surgery and internal fixation to restore the extensor continuity and articular congruity. Fracture fixation with biodegradable magnesium (Mg) pins enhanced fracture healing. We hypothesized that fixation with Mg pins and their degradation over time would enhance healing of patellar fracture radiologically, mechanically, and histologically. Transverse patellar fracture surgery was performed on thirty-two 18-weeks old female New Zealand White Rabbits. The fracture was fixed with a pin made of stainless steel or pure Mg, and a figure-of-eight stainless steel band wire. Samples were harvested at week 8 or 12, and assessed with microCT, tensile testing, microindentation, and histology. Microarchitectural analysis showed that Mg group showed 12% higher in the ratio of bone volume to tissue volume at week 8, and 38.4% higher of bone volume at week 12. Tensile testing showed that the failure load and stiffness of Mg group were 66.9% and 104% higher than the control group at week 8, respectively. At week 12, Mg group was 60.8% higher in ultimate strength than the control group. Microindentation showed that, compared to the Control group, Mg group showed 49.9% higher Vickers hardness and 31% higher elastic modulus at week 8 and 12, respectively. At week 12, the new bone of Mg group remodelled to laminar bone, but those of the control group remained woven bone-like. Fixation of transverse patellar fracture with Mg pins and its degradation enhanced new bone formation and mechanical properties of the repaired patella compared to the Control group.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Biodegradable magnesium pins enhanced the healing of transverse patellar fracture in rabbits

Chow

Wang

Wan

et al. 2021

Bioactive Materials

View full text Add to dashboard Cite

show abstract

“… 13 The high-purity Mg screws also showed acceptable mechanical strength and degradation rates compatible with bone formation for the fixation of femoral neck fractures in goats. 14 Furthermore, the high-purity Mg was studied clinically to fix the vascularized bone grafts for human patients with osteonecrosis of the femoral head (ONFH) and showed a higher Harris hip score (HHS) when compared with the controls using vascularized bone grafting alone without screws. 15 However, it is difficult and expensive to produce Mg of super high purity (>99.9 wt %).…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial Properties of MgO Nanostructures on Magnesium Substrates

et al. 2020

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Magnesium (Mg) and its alloys have attracted increasing attention in recent years as medical implants for repairing musculoskeletal injuries because of their promising mechanical and biological properties. However, rapid degradation of Mg and its alloys in physiological fluids limited their clinical translation because the accumulation of hydrogen (H 2 ) gas and fast release of OH – ions could adversely affect the healing process. Moreover, infection is a major concern for internally implanted devices because it could lead to biofilm formation, prevent host cell attachment on the implants, and interfere osseointegration, resulting in implant failure or other complications. Fabricating nanostructured magnesium oxide (MgO) on magnesium (Mg) substrates is promising in addressing both problems because it could slow down the degradation process and improve the antimicrobial activity. In this study, nanostructured MgO layers were created on Mg substrates using two different surface treatment techniques, i.e., anodization and electrophoretic deposition (EPD), and cultured with Staphylococcus aureus in vitro to determine their antimicrobial properties. At the end of the 24-h bacterial culture, the nanostructured MgO layers on Mg prepared by anodization or EPD both showed significant bactericidal effect against S. aureus . Thus, nanostructured MgO layers on Mg are promising for reducing implant-related infections and complications and should be further explored for clinical translation toward antimicrobial biodegradable implants.

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Strengthening Mechanisms of Ti–Mg Composite for Biomaterials: A Review

Xue,

Luo,

Zhang

et al. 2023

Adv Eng Mater

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Titanium (Ti) has been widely used in biomedical implants due to its excellent mechanical properties and biocompatibility. However, the “stress shielding” effect greatly limits the application of titanium alloys in medical devices. Studies have shown that the incorporation of bioactive elements into the titanium alloy matrix is an effective way to impart specific biological functions to the material through the sustained release of biofunctional elements. Magnesium (Mg) and its alloys have good bioactivity and are potential candidates for biodegradable metal implants. Ti–Mg composites are of increasing interest for biomedical applications. However, the incompatibility between Ti and Mg, such as immiscibility and large melting point difference, has been a great obstacle in preparing Ti–Mg composites. In addition, the biocompatibility of Ti–Mg metal matrix composites in vivo still needs to be further investigated. Herein, the recent research progress of Ti–Mg composites for biomedical implants is reviewed, focusing on their preparation methods and properties. The preparation methods such as powder metallurgy technology and 3D printing are introduced in detail. In addition, the mechanical and corrosion resistance as well as biocompatibility of Ti–Mg composites are discussed. Based on this, the problems and development prospects of Ti–Mg metal matrix composites are presented.

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High-purity weight-bearing magnesium screw: Translational application in the healing of femoral neck fracture

Cited by 67 publications

References 29 publications

Biodegradable magnesium pins enhanced the healing of transverse patellar fracture in rabbits

Biodegradable magnesium pins enhanced the healing of transverse patellar fracture in rabbits

Antimicrobial Properties of MgO Nanostructures on Magnesium Substrates

Strengthening Mechanisms of Ti–Mg Composite for Biomaterials: A Review

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