High quality attenuation-corrected myocardial perfusion images may be achieved in patients with morbid obesity using a whole-body CZT camera and a low-dose injection protocol

Imbert, Laëtitia; Perrin, M.; Claudin, Marine; Boursier, Caroline; Marie, Pierre-Yves

doi:10.1007/s12350-020-02142-z

Cited by 8 publications

(2 citation statements)

References 3 publications

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“…They found two-fold higher sensitivity for the CZT camera and enhancement of grey/white matter contrast. Imbert et al [27] investigated 99m Tc-Sestamibi myocardial perfusion in morbidly obese patients and concluded that it can replicate the characteristics of a dedicated cardiac CZT camera, thus enabling easier management of severely obese patients. Desmonts et al [28] evaluated the CZT camera performance by comparison with a conventional dual-head Anger camera (dual-head Symbia, Siemens Healthineers) for several radioelements ( 99m Tc, 123 I, 201 Tl, 111 In).…”

Section: Physicsmentioning

confidence: 99%

Performance study of a 360° CZT camera for monitoring 177Lu-PSMA treatment

Vergnaud

Badel

Giraudet

et al. 2023

Preprint

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Background: The aim of this study was to investigate the quantification performance of a 360° CZT camera for 177Lu-based treatment monitoring. Methods: Three phantoms with known 177Lu activity concentrations were acquired: 1) a uniform cylindrical phantom for calibration, 2) a NEMA IEC body phantom for analysis of different-sized spheres to optimise quantification parameters, and 3) a phantom containing two large vials simulating organs at risk for tests Four sets of reconstruction parameters were tested: 1) Scatter, 2) Scatter and Point Spread Function Recovery (PSFR), 3) PSFR only and 4) Penalized likelihood option and Scatter, varying the number of updates (iterations × subsets) with CT based attenuation correction only. For each, activity concentration (ARC) and contrast recovery coefficients (CRC) were estimated as well as root mean square. Visualisation and quantification parameters were applied to reconstructed patient image data. Results: Optimised quantification parameters were determined to be: CT-based attenuation correction, scatter correction, 12 iterations, 8 subsets and no filter. ARC, CRC and RMS results were dependant on the methodology used for calculations. Two different reconstruction parameters were recommended for visualisation and for quantification. 3D whole-body SPECT images were acquired and reconstructed for 177Lu-PSMA patients in 2-3 times faster than the time taken for a conventional gamma camera. Conclusion: Quantification of whole-body 3D images of patients treated with 177Lu-PSMA is feasible and an optimised set of parameters has been determined. This camera greatly reduces procedure time whilst providing a final 3D whole-body image.

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Section: Physicsmentioning

confidence: 99%

Performance study of a 360° CZT camera for monitoring 177Lu-PSMA treatment

Vergnaud

Badel

Giraudet

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…They found twofold higher sensitivity for the CZT camera and enhancement of grey/white matter contrast. Imbert et al[ 27 ] investigated 99m Tc-Sestamibi myocardial perfusion in morbidly obese patients and concluded that it can replicate the characteristics of a dedicated cardiac CZT camera, thus enabling easier management of severely obese patients. Desmonts et al[ 28 ] evaluated the CZT camera performance by comparison with a conventional dual-head Anger camera (dual-head Symbia, Siemens Healthineers) for several radioelements ( 99m Tc, 123 I, 201 Tl, 111 In).…”

Section: Introductionmentioning

confidence: 99%

Performance study of a 360° CZT camera for monitoring 177Lu-PSMA treatment

Vergnaud,

Badel,

Giraudet

et al. 2023

EJNMMI Phys

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Background The aim of this study was to investigate the quantification performance of a 360° CZT camera for 177Lu-based treatment monitoring. Methods Three phantoms with known 177Lu activity concentrations were acquired: (1) a uniform cylindrical phantom for calibration, (2) a NEMA IEC body phantom for analysis of different-sized spheres to optimise quantification parameters and (3) a phantom containing two large vials simulating organs at risk for tests. Four sets of reconstruction parameters were tested: (1) Scatter, (2) Scatter and Point Spread Function Recovery (PSFR), (3) PSFR only and (4) Penalised likelihood option and Scatter, varying the number of updates (iterations × subsets) with CT-based attenuation correction only. For each, activity concentration (ARC) and contrast recovery coefficients (CRC) were estimated as well as root mean square. Visualisation and quantification parameters were applied to reconstructed patient image data. Results Optimised quantification parameters were determined to be: CT-based attenuation correction, scatter correction, 12 iterations, 8 subsets and no filter. ARC, CRC and RMS results were dependant on the methodology used for calculations. Two different reconstruction parameters were recommended for visualisation and for quantification. 3D whole-body SPECT images were acquired and reconstructed for 177Lu-PSMA patients in 2–3 times faster than the time taken for a conventional gamma camera. Conclusion Quantification of whole-body 3D images of patients treated with 177Lu-PSMA is feasible and an optimised set of parameters has been determined. This camera greatly reduces procedure time for whole-body SPECT.

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FDG uptake in marrow and spleen: What does it mean?

Scholtens

Verberne

2021

Journal of Nuclear Cardiology

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High quality attenuation-corrected myocardial perfusion images may be achieved in patients with morbid obesity using a whole-body CZT camera and a low-dose injection protocol

Cited by 8 publications

References 3 publications

Performance study of a 360° CZT camera for monitoring 177Lu-PSMA treatment

Performance study of a 360° CZT camera for monitoring 177Lu-PSMA treatment

Performance study of a 360° CZT camera for monitoring 177Lu-PSMA treatment

FDG uptake in marrow and spleen: What does it mean?

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