High-Quality CuInS<sub>2</sub>/ZnS Quantum Dots for In vitro and In vivo Bioimaging

Deng, Dawei; Chen, Yuqi; Cao, Jie; Tian, Jie; Qian, Zhiyu; Achilefu, Samuel; Gu, Yueqing

doi:10.1021/cm3015594

Cited by 269 publications

(323 citation statements)

References 42 publications

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“…10 The following reagents were used as received and without further purification: indium(III) acetate (In(OAc) 3 ) in a three-neck flask. The AgIn 5 S 8 (c-AIS) QDs were synthesized with a non-stoichiometric substrate ratio of (0.5 Â 10 À3 mol) In(OAc) 3 and (0.1 Â 10 À3 mol) AgNO 3 .…”

Section: Synthesis Proceduresmentioning

confidence: 99%

Electronic properties and third-order optical nonlinearities in tetragonal chalcopyrite AgInS₂, AgInS₂/ZnS and cubic spinel AgIn₅S₈, AgIn₅S₈/ZnS quantum dots

et al. 2017

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Comprehensive studies on the electronic properties and spectral dependencies of the third-order nonlinear optical properties of quantum-confined tetragonal chalcopyrite AgInS 2 and its non-stoichiometric cubic spinel AgIn 5 S 8 with reference to their corresponding Zn 2+ alloyed compounds i.e. AgInS 2 /ZnS and AgIn 5 S 8 / ZnS are presented in this work. Nonlinear refraction and nonlinear absorption in the quantum-confined nanocrystals were measured in a wide range of wavelengths (550-1200 nm) using the Z-scan technique.The results revealed the presence of strong two-photon absorption bands in the near-infrared range for both compounds. The impact of Zn 2+ ion alloying was also investigated for both compounds revealing a significant increase of the cubic nonlinearity for the chalcopyrite quantum dots and a negligible change for the spinel-like quantum dots which was discussed as a consequence of different surface reconstruction mechanisms of the tetragonal and cubic nanocrystals. The cubic nonlinearity of the quantum dots is discussed in terms of electronic properties and linear dielectric function dispersions of both systems obtained within the density functional theory. Kinetics of the two-photon excited state recombination was investigated with the femtosecond time-resolved photoluminescence spectroscopy revealing the complex character of electronic relaxation in both systems. The results indicate that the optical properties of the tetragonal AgInS 2 and cubic AgIn 5 S 8 quantum dots are much better suited for the steady-state as well as time-resolved multiphoton fluorescence techniques utilized commonly for bio-sensing applications than their CuIn x S y homologues.

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Section: Synthesis Proceduresmentioning

confidence: 99%

Electronic properties and third-order optical nonlinearities in tetragonal chalcopyrite AgInS₂, AgInS₂/ZnS and cubic spinel AgIn₅S₈, AgIn₅S₈/ZnS quantum dots

et al. 2017

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“…Although core/shell quantum dots typically have photoluminescence spectra which are red-shifted from the core nanocrystals, many groups report a blue shift with CuInS2/ZnS core/shell quantum dots and attribute this to a slight etching of the CuInS2 core size during shell growth. 13,55 The quantum yield of the as synthesized CuInS2/ ZnS quantum dots was determined to be approximately 0.1% relative to the standard dye Coumarin 153 in ethanol. While this quantum yield is low compared to previous reports of CuInS2/ZnS prepared in the aqueous phase, 22 these latter methods required high temperature and/or pressure to form the nanocrystals.…”

mentioning

confidence: 99%

Enzymatic biomineralization of biocompatible CuInS₂, (CuInZn)S₂and CuInS₂/ZnS core/shell nanocrystals for bioimaging

Spangler

Chu

et al. 2017

Nanoscale

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a This work demonstrates a bioenabled fully aqueous phase and room temperature route to the synthesis of CuInS2/ZnS core/shell quantum confined nanocrystals conjugated to IgG antibodies and used for fluorescent tagging of THP-1 leukemia cells. This elegant, straightforward and green approach avoids the use of solvents, high temperatures and the necessity to phase transfer the nanocrystals prior to appli-cation.Non-toxic CuInS2, (CuInZn)S2, and CuInS2/ZnS core/shell quantum confined nanocrystals are synthesized via a biomineralization process based on a single recombinant cystathionine γ-lyase (CSE) enzyme. First, soluble In-S complexes are formed from indium acetate and H2S generated by CSE, which are then stabilized by L-cysteine in solution. The subsequent addition of copper, or both copper and zinc, precursors then results in the immediate formation of CuInS2 or (CuInZn)S2 quantum dots. Shell growth is realized through subsequent introduction of Zn acetate to the preformed core nanocrystals. The size and optical properties of the nanocrystals are tuned by adjusting the indium precursor concentration and initial incubation period. CuInS2/ZnS core/shell particles are conjugated to IgG antibodies using EDC/NHS crosslinkers and then applied in the bioimaging of THP-1 cells. Cytotoxicity tests confirm that CuInS2/ ZnS core/shell quantum dots do not cause cell death during bioimaging. Thus, this biomineralization enabled approach provides a facile, low temperature route for the fully aqueous synthesis of non-toxic CuInS2/ZnS quantum dots, which are ideal for use in bioimaging applications.

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“…This result indicates that CuInS 2 /ZnS QDs could be used for in vivo multiplexed molecular imaging by selecting the appropriate excitation wavelength or filter (not shown here) [162].…”

Section: Luminescencementioning

confidence: 75%

“…Additionally, Gu and co-workers [162] recently demonstrated for the first time the capability for in vivo multiplex imaging, using two different NIR-emitting QDs. A total of 720 nm and 800 nm emitting CuInS 2 /ZnS NCs were injected into the mouse subcutaneously, respectively, in the right and the left paws ( figure 14).…”

Section: Luminescencementioning

confidence: 99%

New generation of magnetic and luminescent nanoparticles for in vivo real-time imaging

et al. 2013

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One contribution of 10 to a Theme Issue 'Molecular-, nano-and micro-devices for real-time in vivo sensing'. A new generation of optimized contrast agents is emerging, based on metallic nanoparticles (NPs) and semiconductor nanocrystals for, respectively, magnetic resonance imaging (MRI) and near-infrared (NIR) fluorescent imaging techniques. Compared with established contrast agents, such as iron oxide NPs or organic dyes, these NPs benefit from several advantages: their magnetic and optical properties can be tuned through size, shape and composition engineering, their efficiency can exceed by several orders of magnitude that of contrast agents clinically used, their surface can be modified to incorporate specific targeting agents and antifolding polymers to increase blood circulation time and tumour recognition, and they can possibly be integrated in complex architecture to yield multi-modal imaging agents. In this review, we will report the materials of choice based on the understanding of the basic physics of NIR and MRI techniques and their corresponding syntheses as NPs. Surface engineering, water transfer and specific targeting will be highlighted prior to their first use for in vivo realtime imaging. Highly efficient NPs that are safer and target specific are likely to enter clinical application in a near future.

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High-Quality CuInS₂/ZnS Quantum Dots for In vitro and In vivo Bioimaging

Abstract: Supporting informationSynthesis and Optical Properties of CIS Core QDs. The temporal evolutions of both absorption

Cited by 269 publications

References 42 publications

Electronic properties and third-order optical nonlinearities in tetragonal chalcopyrite AgInS₂, AgInS₂/ZnS and cubic spinel AgIn₅S₈, AgIn₅S₈/ZnS quantum dots

Electronic properties and third-order optical nonlinearities in tetragonal chalcopyrite AgInS₂, AgInS₂/ZnS and cubic spinel AgIn₅S₈, AgIn₅S₈/ZnS quantum dots

Enzymatic biomineralization of biocompatible CuInS₂, (CuInZn)S₂and CuInS₂/ZnS core/shell nanocrystals for bioimaging

New generation of magnetic and luminescent nanoparticles for in vivo real-time imaging

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High-Quality CuInS2/ZnS Quantum Dots for In vitro and In vivo Bioimaging

Abstract: Supporting informationSynthesis and Optical Properties of CIS Core QDs. The temporal evolutions of both absorption

Cited by 269 publications

References 42 publications

Electronic properties and third-order optical nonlinearities in tetragonal chalcopyrite AgInS2, AgInS2/ZnS and cubic spinel AgIn5S8, AgIn5S8/ZnS quantum dots

Electronic properties and third-order optical nonlinearities in tetragonal chalcopyrite AgInS2, AgInS2/ZnS and cubic spinel AgIn5S8, AgIn5S8/ZnS quantum dots

Enzymatic biomineralization of biocompatible CuInS2, (CuInZn)S2and CuInS2/ZnS core/shell nanocrystals for bioimaging

New generation of magnetic and luminescent nanoparticles for in vivo real-time imaging

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High-Quality CuInS₂/ZnS Quantum Dots for In vitro and In vivo Bioimaging

Electronic properties and third-order optical nonlinearities in tetragonal chalcopyrite AgInS₂, AgInS₂/ZnS and cubic spinel AgIn₅S₈, AgIn₅S₈/ZnS quantum dots

Electronic properties and third-order optical nonlinearities in tetragonal chalcopyrite AgInS₂, AgInS₂/ZnS and cubic spinel AgIn₅S₈, AgIn₅S₈/ZnS quantum dots

Enzymatic biomineralization of biocompatible CuInS₂, (CuInZn)S₂and CuInS₂/ZnS core/shell nanocrystals for bioimaging